Computational mechanisms underlying the dynamics of physical and cognitive fatigue

Matthews, Julian; Pisauro, M. Andrea; Jurgelis, Mindaugas; Müller, Tanja; Vassena, Eliana; Chong, Trevor T.-J.; Apps, Matthew A.J.

doi:10.1016/j.cognition.2023.105603

Cited by 19 publications

(6 citation statements)

References 78 publications

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“…Our findings dovetail with a recent study that found that performance-contingent negative feedback (i.e., on error trials) led to increases in fatigue on mentally demanding tasks (Matthews et al, 2023). While that study also examined fatigue due to physical effort, there were insufficient errors to test for a similar relationship in that domain.…”

Section: Discussionsupporting

confidence: 87%

Do you ever get tired of being wrong? The unique impact of feedback on subjective experiences of effort-based decision-making

Xu,

Frömer,

Wolff

et al. 2023

Preprint

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To achieve a goal, people have to keep track of how much effort they are putting in (effort monitoring) and how well they are performing (performance monitoring), which can be informed by endogenous signals, or exogenous signals providing explicit feedback about whether they have met their goal. Interventions to improve performance often focus on adjusting feedback to direct the individual on how to better invest their efforts, but is it possible that this feedback itself plays a role in shaping the experience of how effortful the task feels? Here, we examine this question directly by assessing the relationship between effort monitoring and performance monitoring. Participants (N = 68) performed a task in which their goal was to squeeze a handgrip to within a target force level (not lower or higher) for a minimum duration. On most trials, they were given no feedback as to whether they met their goal, and were largely unable to detect how they had performed. On a subset of trials, however, we provided participants with (false) feedback indicating that they had either succeeded or failed at meeting their goal (positive vs. negative feedback blocks, respectively). Sporadically, participants rated their experience of effort exertion, fatigue, and confidence in having met the target grip force on that trial. Despite being non-veridical to their actual performance, we found that the type of feedback participants received influenced their experience of effort. When receiving negative (vs. positive) feedback, participants fatigued faster and adjusted their grip strength more for higher target force levels. We also found that confidence gradually increased with increasing positive feedback and decreased with increasing negative feedback, again despite feedback being uniformly uninformative. These results suggest differential influences of feedback on experiences related to effort and further shed light on the relationship between experiences related to performance monitoring and effort monitoring.

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Section: Discussionsupporting

confidence: 87%

Do you ever get tired of being wrong? The unique impact of feedback on subjective experiences of effort-based decision-making

Xu,

Frömer,

Wolff

et al. 2023

Preprint

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“…Third, as participants were required to exert physical effort on each trial, fatigue effects could have developed in the effort discounting task. While our additional analysis confirmed a general fatigue effect and a dual role of haloperidol in both reducing the overall propensity to invest effort and in exacerbating the fatigue effect throughout the task, we acknowledge that recent studies revealed the existence of distinct states of fatigue (Matthews et al, 2023;Müller et al, 2021). Importantly, this was discovered by using task paradigms and computational models that were designed to distinguish between these different types of fatigue.…”

Section: Discussionsupporting

confidence: 60%

Distinct roles of dopamine and acetylcholine in delay- and effort-based decision making in humans

Abdoust,

Froböse,

Schnitzler

et al. 2023

Preprint

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In everyday life, we encounter situations that require tradeoffs between potential rewards and associated costs, such as time and (physical) effort. The literature indicates a prominent role for dopamine in discounting of both delay and effort, with mixed findings for delay discounting in humans. Moreover, the reciprocal antagonistic interaction between dopaminergic and cholinergic transmission in the striatum suggests a potential opponent role of acetylcholine in these processes. We found opposing effects of dopamine D2 (haloperidol) and acetylcholine M1 receptor (biperiden) antagonism on effort discounting in healthy humans: haloperidol decreased, whereas biperiden increased the willingness to exert physical effort. In contrast, delay discounting was reduced under haloperidol, but not affected by biperiden. Together, our data point to a domain-general role of dopamine but a domain-specific role of acetylcholine in human cost-benefit decision making.

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“…Third, as participants were required to exert physical effort on each trial, fatigue effects could have developed in the effort discounting task. While our additional analysis confirmed a general fatigue effect and a dual role of haloperidol in both reducing the overall propensity to invest effort and in exacerbating the fatigue effect throughout the task, we acknowledge that recent studies revealed the existence of distinct states of fatigue [ 83 , 84 ]. Importantly, this was discovered by using task paradigms and computational models that were designed to distinguish between these different types of fatigue.…”

Section: Discussionsupporting

confidence: 56%

Dopamine and acetylcholine have distinct roles in delay- and effort-based decision-making in humans

Erfanian Abdoust,

Froböse,

Schnitzler

et al. 2024

PLoS Biol

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In everyday life, we encounter situations that require tradeoffs between potential rewards and associated costs, such as time and (physical) effort. The literature indicates a prominent role for dopamine in discounting of both delay and effort, with mixed findings for delay discounting in humans. Moreover, the reciprocal antagonistic interaction between dopaminergic and cholinergic transmission in the striatum suggests a potential opponent role of acetylcholine in these processes. We found opposing effects of dopamine D2 (haloperidol) and acetylcholine M1 receptor (biperiden) antagonism on specific components of effort-based decision-making in healthy humans: haloperidol decreased, whereas biperiden increased the willingness to exert physical effort. In contrast, delay discounting was reduced under haloperidol, but not affected by biperiden. Together, our data suggest that dopamine, acting at D2 receptors, modulates both effort and delay discounting, while acetylcholine, acting at M1 receptors, appears to exert a more specific influence on effort discounting only.

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Computational mechanisms underlying the dynamics of physical and cognitive fatigue

Cited by 19 publications

References 78 publications

Do you ever get tired of being wrong? The unique impact of feedback on subjective experiences of effort-based decision-making

Do you ever get tired of being wrong? The unique impact of feedback on subjective experiences of effort-based decision-making

Distinct roles of dopamine and acetylcholine in delay- and effort-based decision making in humans

Dopamine and acetylcholine have distinct roles in delay- and effort-based decision-making in humans

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