Computational Model of SK Channel with Reference to Calcium Dynamics in Bladder Smooth Muscles

Gupta, Suranjana; Manchanda, Rohit

doi:10.2316/p.2016.832-035

Cited by 5 publications

(3 citation statements)

References 20 publications

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“…Alginate was purified as previously described. 42 3 mL of 1.65 wt% alginate in PBS was loaded into a 5 mL syringe, and all bubbles were removed. In another 5 mL syringe, 750 μL of 150 mM CaSO 4 in PBS containing 1% (v/v) Fungizone was collected.…”

Section: Air Interface Culture 3d Multicellular Spheroid (Mcs) Evaluamentioning

confidence: 99%

Development and Evaluation of Paclitaxel-Loaded Aerosol Nanocomposite Microparticles and Their Efficacy Against Air-Grown Lung Cancer Tumor Spheroids

Guzmán

Sun

Meenach

2019

ACS Biomater. Sci. Eng.

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Paclitaxel (as intravenous Taxol) is one of the most applied chemotherapeutics used for the treatment of lung cancer. This project involves the development of a dry powder nanocomposite microparticle (nCmP) aerosol containing PTX-loaded nanoparticles (NP) to be delivered via a dry powder inhaler to the lungs for the treatment of non-small cell lung cancer (NSCLC). Nanoparticles were formulated by a single emulsion and solvent evaporation method, producing smooth, neutral PTX NP of approximately 200 nm in size. PTX nCmP were obtained via spray drying PTX NP with mannitol, producing amorphous wrinkled particles that demonstrated optimal aerosol deposition for in vitro pulmonary delivery. Free PTX, PTX NP, and PTX nCmP were evaluated in vitro in both 2D monolayers and 3D multicellular spheroids (MCS). PTX NP enhanced cytotoxicity when compared to pure drug in the 2D evaluation. However, on a liquid culture 3D tumor spheroid model, PTX NP and pure PTX showed similar efficacy in growth inhibition of MCS. The PTX nCmP formulation had a comparable cytotoxicity impact on MCS compared with free PTX. Finally, PTX nCmP were evaluated in an air-grown 3D MCS platform that mimics the pulmonary environment, representing a new model for the assessment of dry powder formulations.

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Section: Air Interface Culture 3d Multicellular Spheroid (Mcs) Evaluamentioning

confidence: 99%

Development and Evaluation of Paclitaxel-Loaded Aerosol Nanocomposite Microparticles and Their Efficacy Against Air-Grown Lung Cancer Tumor Spheroids

Guzmán

Sun

Meenach

2019

ACS Biomater. Sci. Eng.

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“…To better evaluate renal function using TAC of kidneys, we calculated the slope of initial uptake (SIU, min -1 , slope of kidney TAC from 10 to 50 second p.i. ), peak uptake (%ID/g), time to peak (min), and washout half-life (half-life of DTN in the kidneys measured by applying a one-compartment fitting model) [17,18]. SIU of DTN in healthy mice, representing the speed of kidney perfusion, was 31.2 ± 2.1 min -1 .…”

Section: Pet Imaging Of Dtn In Healthy Micementioning

confidence: 99%

Efficient renal clearance of DNA tetrahedron nanoparticles enables quantitative evaluation of kidney function

Jiang

Boleyn

et al. 2018

Nano Res.

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DNA tetrahedron nanostructure (DTN) is one of the simplest DNA nanostructures and has been successfully applied for biosensing, imaging, and treatment of cancer. To facilitate its biomedical applications and potential clinical translation, fundamental understanding of DTN's transportation among major organs in living organisms becomes increasingly important. Here, we describe the efficient renal clearance of DTN in healthy mice by using positron emission tomography (PET) imaging. The kidney elimination of DTN was later applied for renal function evaluation in murine models of unilateral ureteral obstruction (UUO). We further established a mathematical program of DTN to validate its changes of transportation pattern in healthy and UUO mice. We believe the establishment of pharmacokinetic profiles and mathematical model of DTN may provide insight for future optimization of DNA nanostructures for biomedical applications.

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“…Initially monazite sand is treated with highly alkaline solution of sodium hydroxide thus; thorium is obtained in the form of thorium hydroxide. Among various salts of thorium, especially thorium oxalate is used for producing a required molecule of thorium oxide which is further used as fuel [4,5] and therefore the thorium hydroxide so formed is then reacted with nitric acid to obtain thorium nitrate and finally converted into thorium oxalate [6,7].…”

Section: Introductionmentioning

confidence: 99%

A novel process for the synthesis of “Designed Molecular Precursor” (DMP) of thorium useful for broad application spectrum

Verma

Amritphalae

2015

J Radioanal Nucl Chem

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For the first time (Patent application filed in India vide N/F No-0018NF2015) a novel process for the synthesis of ''Designed Molecular Precursor'' (DMP) of thorium has been developed, which involves the unique combination of two different (dual) capping agents, one is biomolecule: Cytosine and other is non biomolecule : cetyl trimethyl ammonium bromide. The DMP essentially consists of hybrid nanosized thorium oxalate and alkaline thorate whose application lies in the area of making thorium metal, densified thorium oxide, carbide and nitride, anhydrous thorium complexes and thorium boron silicates glasses.

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Computational Model of SK Channel with Reference to Calcium Dynamics in Bladder Smooth Muscles

Cited by 5 publications

References 20 publications

Development and Evaluation of Paclitaxel-Loaded Aerosol Nanocomposite Microparticles and Their Efficacy Against Air-Grown Lung Cancer Tumor Spheroids

Development and Evaluation of Paclitaxel-Loaded Aerosol Nanocomposite Microparticles and Their Efficacy Against Air-Grown Lung Cancer Tumor Spheroids

Efficient renal clearance of DNA tetrahedron nanoparticles enables quantitative evaluation of kidney function

A novel process for the synthesis of “Designed Molecular Precursor” (DMP) of thorium useful for broad application spectrum

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