2024
DOI: 10.21203/rs.3.rs-4544670/v1
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Computational modeling of insect odorant receptors: A comparative analysis of Template-based and Alphafold modeling

Amara Jabeen,
John Oakeshott,
Siu Fai Lee
et al.

Abstract: Insects rely on odorant receptors (ORs) to detect and respond to volatile environmental cues, so the ORs are attracting increasing interest as potential targets for pest control. However, experimental analysis of their structures and functions faces significant challenges. Computational methods such as template-based modeling (TBM) and Alphafold2 (AF) could facilitate the structural characterisation of ORs. This study first showed that both models accurately predicted the structural fold of MhOR5, a jumping br… Show more

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