“…This model has been used in studies related to respiratory modeling not only by the same author [28,36,37] but also by others [38,39,40]. Recently, several studies have used its cost functions to determine the breathing pattern in subjects under assisted mechanical ventilation [39,41,42,43]. The WOB depended on model parameters whose values were not provided in any of the previous studies [9,28,36,37,38,39,40,41,42,43], which suggests that respiratory control modeling based on optimization criteria needs additional experimental and computational efforts.…”