2024
DOI: 10.1101/2024.06.17.597714
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Computational pipeline for targeted integration and variable payload expression for bacteriophage engineering

Jonas Fernbach,
Emese Hegedis,
Martin J. Loessner
et al.

Abstract: Bacteriophages offer a promising alternative to conventional antimicrobial treatments, particularly in cases where such treatments have proven ineffective. While naturally occurring phages serve as viable options for phage therapy, advances in synthetic biology and genome engineering enable precise modifications to phages to enhance their therapeutic potential. One such approach is the introduction of antimicrobial genetic payloads into the phage genome. Conventional practice is to integrate such payloads behi… Show more

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