Computational simulation of carotid stenosis and flow dynamics based on patient ultrasound data – A new tool for risk assessment and surgical planning

Sousa, Luísa Costa; Castro, Catarina; Curnis, Antonio; Sousa, Fernando; Santos, Rosa; Castro, Pedro; Azevedo, Elsa

doi:10.1016/j.advms.2015.07.009

Cited by 28 publications

(22 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The patient-specific hemodynamic study presented is done using Doppler US imaging data; five sequential steps are required [7,8]: data acquisition, lumen segmentation of longitudinal and transversal carotid images, 3D carotid bifurcation surface reconstruction, mesh generation and hemodynamic simulation.…”

Section: Methodsmentioning

confidence: 99%

“…Previous works on patient-specific hemodynamic combining manual or semi-automatic image segmentation with finite element blood flow simulation have been performed [7,8]. Like those studies this research presents a patient-specific study, considering a threedimensional (3D) model of the bifurcation wall reconstructed from segmented B-mode US and blood flow velocity spectral waveforms obtained from PW Doppler images.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Blood Flow in the Common Carotid Artery With Stenosis

Henriques¹,

Sousa²,

Castro³

et al. 2016

Proceedings of the VII European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS Congress 2016)

Self Cite

View full text Add to dashboard Cite

This work presents the development of a computational methodology based on ultrasound (US) data and able to simulate the hemodynamics of a carotid bifurcation with stenosis. A semi-automatic lumen segmentation methodology of longitudinal and cross-sectional images is presented. The algorithm, implemented in Matlab is based on the hypoecogenic characteristic of the lumen and allows the lumen contour extraction in 2D B-mode images. Patient-specific Womersley velocity profiles, derived from the pulsatile velocity waveforms obtained by pulsed Doppler images, were considered for the definition of the boundary conditions. An image based computational fluid dynamics model of a middle-aged patient was reconstructed from both segmented transversal and longitudinal US images. The blood flow simulation was performed using the Ansys/Fluent software. Pulsatile conditions of the hemodynamic analysis were validated by the carotid US scan. Hemodynamic analysis was performed based on wall shear stress (WSS) descriptors. High values of time-averaged wall shear stress (TAWSS) were captured within stenosis. Low values of TAWSS where found at the carotid bulb, upstream and downstream stenosis and also at external carotid artery. In these regions the oscillatory shear index (OSI) and the relative residence time (RRT) present high values, in agreement with the fact these hemodynamic descriptors are able to capture abnormal flow conditions witch present an import role in the local development of atherosclerotic plaques. This study shows to be clinically useful in the diagnosis and management of the treatment of carotid stenosis as it is able to show a complex hemodynamic behaviour during the cardiac cycle allowing the correlation between the carotid wall pathophysiology and the local influence in artery hemodynamics.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Blood Flow in the Common Carotid Artery With Stenosis

Henriques¹,

Sousa²,

Castro³

et al. 2016

Proceedings of the VII European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS Congress 2016)

Self Cite

View full text Add to dashboard Cite

show abstract

“…With that aim, computational modelling of atherosclerosis has been performed in recent years (Parton et al 2016). Also, the relation between atherosclerosis progression and existence of blood recirculation zone, low wall shear stress and high oscillating shear index within the carotid arteries have been studied (Sousa et al 2016). The mechanisms of atherosclerosis have been used to provide insights for understanding the processes which lead to plaque initiation and development, as well as to predict plaque regions and mechanisms which are prone to disease progression (Filipovic et al 2013;Bourantas et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Computational Simulation of Carotid Artery: From Patient-Specific Images to Finite Element Analysis

Djorovic¹,

Šaveljić²,

Filipović³

2019

JSSCM

View full text Add to dashboard Cite

Nowadays, finite element analysis is a well-assessed technique which enables investigation of blood vessels behavior under different boundary conditions. Given the rapid progression of both medical imaging techniques and computational methods, the challenge of using the simulation of human arteries such as carotid arteries to address different medical conditions and support the clinical practice can be approached. Within this context, this study investigates the recent achievements in the field of computational examinations of carotid artery and presents the method for analysis of patient-specific carotid artery model and its application for simulation of atherosclerosis progression. In particular, we focus on the patient-specific anatomical geometry reconstruction and then on the examination of the plaque progression within carotid artery, by examining the parameters such as blood velocity and shear stress distribution. This type of simulation and determination of plaque zone and its progression in time for a specific patient has shown a potential benefit for future prediction of this vascular disease using the computer simulation.

show abstract

“…Задача оптимизации такова -определить режимы работы экструдера, чтобы они в широком диапазоне изменения вxодныx параметров продукта составляли минимальные удельные энергозатраты, оптимальное давление в предматричной зоне и максимальный комплексный органолептический показатель качества. Общая математическая постановка задачи оптимизации дана в виде модели [2,6]: 1 1 2 3 4 5 2 1 2 3 4 5 3 1 2 3 4 5 , , opt Подставив значения коэффициентов уравнений (2)-(4) в матрицу (6) и решив нелинейные уравнения 5-й степени, вычислили канонические коэффициенты. После анализа полученныx каноническиx уравнений выяснили, что изучаемые тела в 5-мерном пространстве принадлежат к типу «минимакса»: при движении в направлении осей, у которыx Xi положительны, от центра оптимизации идет возрастание значений выxодныx параметров, а в направлении осей, для которыx Xi отрицательны, снижение.…”

Section: Introductionunclassified

“…После анализа полученныx каноническиx уравнений выяснили, что изучаемые тела в 5-мерном пространстве принадлежат к типу «минимакса»: при движении в направлении осей, у которыx Xi положительны, от центра оптимизации идет возрастание значений выxодныx параметров, а в направлении осей, для которыx Xi отрицательны, снижение. Противоположные знаки коэффициентов каноническиx уравнений влияют на то, что поверxности отклика -это одно-или двуxполосный гиперболоид [5][6][7][8][9].…”

Section: Introductionunclassified

Software of the extrusion process abnormally viscous fluids methods of experiment planning

Василенко

Фролова

Дерканосова

et al. 2018

Vestn. Voronež. gos. univ. inž. tehnol.

View full text Add to dashboard Cite

Article is devoted to the results of modeling-a certain mathematical function that describes the behavior of the object of study, abstracting from the internal structure of the real substrate. Materials and Methods: discusses the construction of models of experimental dependencies extruding abnormally viscous fluids, includes the following stages: clarification, depending on the specific tasks optimized parameters (specific energy consumption in the extrusion process, the pressure in predatrice area, complex organoleptic quality score, etc.); the choice of factors determining the variability of the optimized parameters (initial moisture of the product, the frequency of rotation of the screw, the living section of the matrix, etc.); the selection of intervals of change of factors; recruitment plan and the conditions of the experiment; analysis of experiment data and construction of mathematical model of dependencies of optimized parameters on selected factors.Results: when planning an experiment, the conditions for conducting experiments, obtaining reliable and accurate information about the object, with minimal effort, providing information in a convenient form and quantitative accuracy assessment. Discussion: the problem of optimization of the studied process was solved, which allows to find such modes of the extruder, which would be in a wide range of changes in the input parameters of the product amounted to a minimum of specific energy consumption, the optimal pressure in the pre-matrix zone and the maximum complex organo-leptic quality index. Conclusion: the obtained results reveal the influence of individual factors on the operation of extruders and can be used in the design and optimization of their operation. They will have an impact on the development of scientific, scientific, technical and technological directions in the field of creating new food products with programmable properties (including therapeutic and prophylactic action). Made on their basis, experimental design will reveal new technological solutions in the field of creation of new generation technological equipment for various branches of the food industry. The developed recommendations and proposals for the use of the results are already used in the ongoing innovative projects for the creation of extruders, as well as other equipment.

show abstract

Computational simulation of carotid stenosis and flow dynamics based on patient ultrasound data – A new tool for risk assessment and surgical planning

Cited by 28 publications

References 46 publications

Blood Flow in the Common Carotid Artery With Stenosis

Blood Flow in the Common Carotid Artery With Stenosis

Computational Simulation of Carotid Artery: From Patient-Specific Images to Finite Element Analysis

Software of the extrusion process abnormally viscous fluids methods of experiment planning

Contact Info

Product

Resources

About