2024
DOI: 10.3390/ijms252011154
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Computational Strategies for Assessing Adverse Outcome Pathways: Hepatic Steatosis as a Case Study

Rita Ortega-Vallbona,
Martina Palomino-Schätzlein,
Laia Tolosa
et al.

Abstract: The evolving landscape of chemical risk assessment is increasingly focused on developing tiered, mechanistically driven approaches that avoid the use of animal experiments. In this context, adverse outcome pathways have gained importance for evaluating various types of chemical-induced toxicity. Using hepatic steatosis as a case study, this review explores the use of diverse computational techniques, such as structure–activity relationship models, quantitative structure–activity relationship models, read-acros… Show more

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