Computational Studies on Effects of 1-(4-Chlorobenzylideneamino)-4-Phenyl-1H-Imidazol-2-Amine as an Anticancer Drug on DNA

Abstract

Abstract-Extensive studies conducted by investigators have led into discover of anticancer properties of compounds drived from Imidazole. Considering the fact that the series of compounds being new and the defects in the drugs available, which cause complications in the DNA string, the need for finding ways to cope that challenge is immiment. The value and the accuracy of computational methods, led us to choose the 4 nucleotides, Adenine, Cytosine, Guanine and Thymine as a measure of the DNA string and study the effect of the compound 1-(4-chlorobenzylideneamino)-4-phenyl-1H-imidazol-2-amine as a new biologic Imidazole anticancer drug, the medicinal effect of which has recently been established, on any of these DNA string nucleotides. The studies reveal the fact that the highest amount of interaction between the drug and the nucleotide is on Guanine. Then to conduct a through careful review, we checked all different constructible possibilities of drug containing (Imidazole ring, Phenyl and Chlorine atom) and Guanine nucleobase. IndexTerms-1-(4-chlorobenzylideneamino)-4-phenyl-1H-imidazol-2-amine, nucleotide, nucleobase, anticancer drug.

Surface-Enhanced Raman Scattering (SERS) in Combination with PCA and PLS-DA for the Evaluation of Antibacterial Activity of 1-Isopentyl-3-pentyl-1H-imidazole-3-ium Bromide against Bacillus subtilis

“…For medical purposes, imidazole and its derivatives are often utilized as antibiotics, 13 antifungal, 14 and anticancerous. 15 Antibacterial drugs based on imidazole and imidazolium derivative salts have been investigated against Bacillus spp. 16,17 for causing a number of harmful infections such as osteomyelitis, meningitis, anthrax, endocarditis, and ophthalmitis.…”