Computational study on synovial fluid flow behaviour in cartilage contact gap under osteoarthritic condition

Liao, JinJing; Miramini, Saeed; Liu, Xuanchi; Zhang, Lihai

doi:10.1016/j.compbiomed.2020.103915

Cited by 23 publications

(8 citation statements)

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“…To accurately simulate the gap flow, two cartilage surface roughness profiles measured from the bovine lateral femur (LF) and medial tibia (MT) using a Dektak stylus profilometer from previous studies [37,39] were adopted in this study. The samples (n = 3 for each condyle) were stored at -20 ℃; prior to testing, they were thawed in phosphate-buffered saline (PBS) to room temperature.…”

Section: Contact Gap Flow and Gap Permeabilitymentioning

confidence: 99%

“…During the measurement, the moisture of the samples was maintained throughout the imaging process. The samples were scanned at a speed of 100 μm/s with a resolution of 0.33 μm/pt on the y-axis and 200 scans were conducted on the x-axis, and the resolution of the z-axis was 8 nm [37,39]. Both roughness profiles were for an area measuring 1,000 μm × 1,000 μm.…”

Section: Contact Gap Flow and Gap Permeabilitymentioning

confidence: 99%

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Investigation of role of cartilage surface polymer brush border in lubrication of biological joints

et al. 2021

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Although experimental evidence has suggested that the polymer brush border (PBB) on the cartilage surface is important in regulating fluid permeability in the contact gap, the current theoretical understanding of joint lubrication is still limited. To address this research gap, a multiscale cartilage contact model that includes PBB, in particular its effect on the fluid permeability of the contact gap, is developed in this study. Microscale modeling is employed to estimate the permeability of the contact gap. This permeability is classified into two categories: For a gap size > 1 µm, the flow resistance is assumed to be dominated by the cartilage roughness; for gap size < 1 µm, flow resistance is assumed to be dominated by the surface polymers extending beyond the collagen network of the articular cartilage. For gap sizes of less than 1 µm, the gap permeability decreases exponentially with increasing aggrecan concentration, whereas the aggrecan concentration varies inversely with the gap size. Subsequently, the gap permeability is employed in a macroscale cartilage contact model, in which both the contact gap space and articular cartilage are modeled as two interacting poroelastic systems. The fluid exchange between these two media is achieved by imposing pressure and normal flux continuity boundary conditions. The model results suggest that PBB can substantially enhance cartilage lubrication by increasing the gap fluid load support (e.g., by 26 times after a 20-min indentation compared with the test model without a PBB). Additionally, the fluid flow resistance of PBB sustains the cartilage interstitial fluid pressure for a relatively long period, and hence reduces the vertical deformation of the tissue. Furthermore, it can be inferred that a reduction in the PBB thickness impairs cartilage lubrication ability.

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Section: Contact Gap Flow and Gap Permeabilitymentioning

confidence: 99%

Section: Contact Gap Flow and Gap Permeabilitymentioning

confidence: 99%

Investigation of role of cartilage surface polymer brush border in lubrication of biological joints

et al. 2021

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“…Synovial fluid is a non-Newtonian fluid encapsulated in the synovial cavity of the major joints of human and animal bodies [1]. Its major functions include cushioning and steady load absorption during loading and providing a minimum coefficient of friction for smooth movement between the bones of the joint [2].…”

Section: Introductionmentioning

confidence: 99%

Rheological Properties and Its Effect on the Lubrication Mechanism of PVP K30 and PVP 40-50 G as Artificial Synovial Fluids

Kotia

Yadav

et al. 2021

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The effect of polyvinylpyrrolidone (PVP) on the rheological properties of joint prostheses is still unclear, despite its good lubricity and biocompatibility. In the present work, PVP K30 and PVP 40-50 G solutions at different concentrations were analyzed for rheological and lubrication properties. The rheological properties of the samples were measured at a shear rate range of 0–1800 s−1 (advanced air bearing rheometer Bohlin Gemini 2 and Plate MCR 72/92 rheometer for PVP30 and PVP 40-50 G, respectively). It was found that both the viscosity and shear stress of the samples reduced with a shear rate increase. PVP 40-50 G/sterile water showed higher viscosity as compared to the PVP K30/sterile water sample at a lower shear rate. However, at a higher shear rate, the PVP K30 sample produced better results. Further numerical study results showed the pressure and molecular viscosity distributions. The inclusion of PVP improved the load caring capacity and hence, it is a promising lubrication additive for artificial joints.

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“…The non-Newtonian synovial fluid in the joint cavity, produced by the synovium, provides a lubricating film less than 15 µm thick [1] for these contacting surfaces. The lubricating properties of this fluid are mainly due to the presence of glycoproteins like hyaluronate and lubricin [1,10,12,13]. The synovial fluid also serves as the primary medium of nutrient delivery for the cartilage cells due to their lack of a direct blood supply [14].…”

Section: Diarthrodial Jointsmentioning

confidence: 99%

“…The degeneration of the cartilage is typically accompanied by a remodeling of the underlying subchondral bone, development of osteophytes, narrowing of the joint space, and various biochemical changes in the joint as a whole [4,9]. Degradation of the synovial fluid is also typical in osteoarthritic joints, hindering its fluid film lubrication properties [13].…”

Section: Osteoarthritismentioning

confidence: 99%

Raman Spectroscopy-based Analysis of Cartilage Composition with Applications in Finite Element Modeling

Mason¹

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Computational study on synovial fluid flow behaviour in cartilage contact gap under osteoarthritic condition

Cited by 23 publications

References 50 publications

Investigation of role of cartilage surface polymer brush border in lubrication of biological joints

Investigation of role of cartilage surface polymer brush border in lubrication of biological joints

Rheological Properties and Its Effect on the Lubrication Mechanism of PVP K30 and PVP 40-50 G as Artificial Synovial Fluids

Raman Spectroscopy-based Analysis of Cartilage Composition with Applications in Finite Element Modeling

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