Computed Tomography and Magnetic Resonance Imaging Features of Lesions of the Renal Medulla and Sinus

Nikolaidis, Paul; Gabriel, Helena; Khong, Kathleen; Brusco, Michael J.; Hammond, Nancy; Yagmai, Vahid; Casalino, David D.; Hoff, Frederick L.; Patel, Suresh K.; Miller, Frank R.

doi:10.1067/j.cpradiol.2007.09.002

Cited by 12 publications

(4 citation statements)

References 37 publications

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“…Multiple imaging modalities can be used to assess the development of renal lesions in humans, including renal sinus fat accumulation, such as ultrasonography, CT, and magnetic resonance imaging [22][23][24]. Further, CT has been used to develop a feasible and reproducible measurement protocol for characterizing the distribution of RS fat in a sample from the Framingham MDCT cohort [20].…”

Section: Discussionmentioning

confidence: 99%

Volumetric evaluation of renal sinus adipose tissue on computed tomography images in bilateral nephrolithiasis patients

et al. 2020

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Purpose To compare renal sinus fat volume (RSFV) separately within the right and left kidneys between bilateral nephrolithiasis patients and healthy controls. Methods This cross-sectional study analyzed patients who underwent unenhanced abdominal computed tomography (CT) divided into nephrolithiasis (n = 102) and healthy control (n = 130) groups. Age, sex, blood pressure [systolic blood pressure (SBP) and diastolic blood pressure (DBP)], estimated glomerular filtration rate (eGFR), body weight, and height of each participant were extracted. Volumetric renal sinus adipose tissue was measured separately for both kidneys on CT images. Urea, serum creatinine (Scr), uric acid (UA), total serum cholesterol (TCH), serum triglyceride (TG), and serum high- and low-density lipoprotein (HDL and LDL, respectively) cholesterol levels were obtained. Results Overall, 232 participants (mean age 47 years, 50% women) were enrolled. There were no differences in sex, DBP, urea, and LDL-cholesterol between the two groups (all p > 0.05). However, nephrolithiasis patients had higher age, BMI, SBP, and RSFV; higher Scr, UA, TCH, and TG serum levels; and lower HDL-cholesterol level and eGFR. Average left RSFV was significantly higher than right RSFV in healthy controls (4.56 ± 2.29 versus 3.34 ± 1.90 cm3, p < 0.001). A significant relationship between bilateral RSFV, age, BMI, SBP, and eGFR was noted in bilateral nephrolithiasis patients. Multivariate linear regression analysis showed age, BMI, and LDL-cholesterol to be independent predictors of left RSFV, and only BMI was an independent predictor of right RSFV. Conclusions Our data showed renal sinus adipose tissue accumulation and the relationship among RSFV, age, BMI, and LDL-cholesterol in bilateral nephrolithiasis patients.

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Section: Discussionmentioning

confidence: 99%

Volumetric evaluation of renal sinus adipose tissue on computed tomography images in bilateral nephrolithiasis patients

et al. 2020

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“…Computed tomography, among other imaging techniques, has been used to assess the development of renal lesions in humans, including renal sinus fat accumulation [32,33]. Previous small imaging studies using magnetic resonance imaging have demonstrated fat accumulation in the renal sinus of children with no known renal disease (n = 15 of 58 participants) [26] and adults [27].…”

Section: Discussionmentioning

confidence: 99%

Development and reproducibility of a computed tomography-based measurement of renal sinus fat

et al. 2011

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BackgroundRenal sinus fat may mediate obesity-related vascular disease, although this fat depot has not been assessed in a community-based sample. We sought to develop a protocol to quantify renal sinus fat accumulation using multi-detector computed tomography (MDCT).MethodsProtocol development was performed in participants in the Framingham Offspring cohort who underwent MDCT. Volumetric renal sinus fat was measured separately within the right and left kidneys, and renal sinus fat area within a single MDCT scan slice was measured in the right kidney. Due to the high correlation of volumetric and single-slice renal sinus fat in the right kidney (Pearson correlation [r] = 0.85, p < 0.0001), we optimized a single-slice protocol to capture renal sinus fat in the right kidney alone. Pearson correlation coefficients were used to compare to assess the correlation of volumetric and single-slice renal sinus fat in the right kidney with other measures of adiposity. Inter- and intra-reader reproducibility was assessed using intra-class correlation coefficients.ResultsSingle-slice measurements were obtained in 92 participants (mean age 60 years, 49% women, median renal sinus fat 0.43 cm2). Intra- and inter-reader intra-class correlation coefficients were 0.93 and 0.86, respectively. Single-slice renal sinus fat was correlated with body mass index (r = 0.35, p = 0.0006), waist circumference (r = 0.31, p = 0.003), and abdominal visceral fat (r = 0.48, p < 0.0001). Similar correlations were observed for volumetric renal sinus fat in the right kidney.ConclusionsMeasuring renal sinus fat is feasible and reproducible using MDCT scans in a community-based sample.

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“…Various imaging modalities can be used for examination of the RS, such as ultrasonography, CT, magnetic resonance imaging and angiography. CT is the most sensitive, efficient, and comprehensive imaging modality for examination of RS [19,22]. Therefore, in this study CT images were used for volume measurements of RS.…”

Section: Discussionmentioning

confidence: 99%

“…This area may be affected by various pathologic conditions arising from the different tissues within the RS [19].Tumorous and nontumorous lesions can occur in RS. These lesions include lipomatosis, RS cysts, vascular lesions and fluid collections.…”

Section: Introductionmentioning

confidence: 99%

Volumetric evaluation of fat in the renal sinus in normal subjects using stereological method on computed tomography images and its relationship with body composition

et al. 2014

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Computed Tomography and Magnetic Resonance Imaging Features of Lesions of the Renal Medulla and Sinus

Cited by 12 publications

References 37 publications

Volumetric evaluation of renal sinus adipose tissue on computed tomography images in bilateral nephrolithiasis patients

Volumetric evaluation of renal sinus adipose tissue on computed tomography images in bilateral nephrolithiasis patients

Development and reproducibility of a computed tomography-based measurement of renal sinus fat

Volumetric evaluation of fat in the renal sinus in normal subjects using stereological method on computed tomography images and its relationship with body composition

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