Computed Tomography-Guided Screening of Surfactant Effect on Blood Circulation Time of Emulsions: Application to the Design of an Emulsion Formulation for Paclitaxel

Abstract

CT-visible, Lipiodol emulsions enabled the simple evaluation of surfactant composition effects on the biodisposition of emulsions.

Development of paclitaxel-loaded liposomal nanocarrier stabilized by triglyceride incorporation

“…30 The system was used in the auto-measuring mode. Particle size analysis data were evaluated using volume distribution to detect even a few large droplets.…”

“…30 In brief, 50 µL of liposome dispersions containing PTX were freeze-dried and dissolved in 1 mL of methanol and centrifuged at 13,200 rpm for 10 minutes. The supernatant PTX samples were determined by using Nanospace SI-2 HPLC system (Shiseido Co., Ltd, Tokyo, Japan) equipped a mobile phase delivery pump (SP 3201) and UV-visible detector (SP 3002).…”

Effects of triglycerides on the hydrophobic drug loading capacity of saturated phosphatidylcholine-based liposomes

“…The mean particle size and polydispersity index (PI) of liposome dispersions were determined by dynamic light-scattering method using fiber-optics particle analyzer (FPAR-1000, Otsuka Electronics, Japan) as described earlier (Lee et al, 2014). Prior to measurement, dispersions were diluted 100 times with filtered saline.…”

Enhancement of indocyanine green stability and cellular uptake by incorporating cationic lipid into indocyanine green-loaded nanoemulsions

“…The SA-incorporated, ICG-loaded nanoemulsions described in the present study leave the inner oil core available as a space for loading another anticancer drug. In this context, we previously demonstrated the feasibility of loading the anticancer drug paclitaxel in Lipiodol emulsions [28]. Further studies are warranted to investigate the combined effect of chemotherapy and photodynamic/photothermal therapy of cancer metastasis using SA-incorporated nanoemulsions as a dual carrier for ICG and paclitaxel.…”

“…SA incorporation increased the droplet sizes of nanoemulsions by 1.7-fold, probably because of the increase in lipophilic cosurfactant (SA) content in the surfactant mixture. To produce stable oil-in-water Lipiodol emulsions with a small, homogeneous size distribution, a surfactant mixture composed of hydrophilic surfactant (Tween80):lipophilic cosurfactant (Span85) containing ≤13 mol% lipophilic cosurfactant was found to be optimal in our previous study [28]. The mean droplet sizes and PI of Tween80:Span85 nanoemulsions were decreased by loading ICG in the absence of SA, which also increased the negativity of the weakly negative zeta potential value of Tween80:Span85 emulsions (from −10.8 to −39.7 mV).…”