Computer-aided design of short-lived phosphorescent Ru(II) polarity probes

Ielasi, Guido; Alcover, Gerard; Casellas, Josep; Graaf, Coen de; Orellana, Guillermo; Reguero, Mar

doi:10.1016/j.dyepig.2018.10.015

Cited by 4 publications

(1 citation statement)

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“…Upon excitation at the 1 MLCT absorption wavelength, a strong solvatochromism was observed for Ru2 from CH 2 Cl 2 (588 nm) to H 2 O (700 nm), suggesting a significantly strong solvent–complex interaction at the excited state. Such a large red shift has rarely been reported in Ru(II) complexes − and is much more evident than a red shift of only about 25 nm observed for the emission of Ru1 from CH 2 Cl 2 (600 nm) to H 2 O (625 nm) and even a maximum red shift of 40 nm from CH 2 Cl 2 (600 nm) to EtOAc (640 nm). The luminescence quantum yields of Ru1 and Ru2 were measured using [Ru(bpy) 3 ] 2+ in water as a standard.…”

Section: Resultsmentioning

confidence: 64%

Near-IR/Visible-Emitting Thiophenyl-Based Ru(II) Complexes: Efficient Photodynamic Therapy, Cellular Uptake, and DNA Binding

Zhang

Meng

et al. 2019

Inorg. Chem.

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Near-IR-emitting and/or efficiently photodynamic water-soluble Ru(II) complexes that hold great application potentials as photodynamic therapy and/or photodetection agents for cancers have been poorly explored. In this paper, the solvatochromism, calf thymus DNA binding, and singlet oxygen generation properties of a known ruthenium(II) complex of visible-emitting [Ru(bpy)2(dtdpq)](ClO4)2 (Ru1) and a new homoleptic complex of near-IR-emitting [Ru(dtdpq)3](ClO4)2 (Ru2) (bpy = 2,2′-bipyridine, dtdpq = 2,3-bis(thiophen-2-yl)pyrazino[2,3-f][1,10]phenanothroline) in water are reported. Moreover, DNA photocleavage, singlet oxygen generation in HeLa cells, cellular uptake/localization, and in vitro photodynamic therapy for cancer cells of water-soluble Ru1 are described in detail. The results show that Ru1 acted as potent photodynamic cancer therapy and mitochondrial imaging agents. Ru2 exhibited very strong solvatochromism from a visible emission maximum at 588 nm in CH2Cl2 to the near-IR region at 700 nm in water and singlet oxygen generation yield in water (23%) and DNA binding properties (intercalative DNA binding constant on the order of 106 M–1) comparable to those of Ru1, which should make Ru2 attractive for the aforementioned applications of Ru1 if the water solubility of Ru2 can be improved enough for the studies above.

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