Computer-Aided Tunnel Engineering: A Promising Strategy for Improving Lipase Applications in Esterification Reactions
Wenya Chong,
Yuan Qi,
Liran Ji
et al.
Abstract:Esterification
is one of the most important reactions in organic
synthesis and industrial applications. The applications of lipases
in esterification are increasingly widespread and have high cumulative
values. Mostly, in the catalytic cycle of lipases, the tunnel connecting
the active site to the surface of a protein plays a significant role
in ligand transport. As a unique conformational structure of a protein,
the tunnel could regulate the catalytic performance of lipases via
ligand transportation. Therefor… Show more
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