Computer Simulation of Blood Flow, Left Ventricular Wall Motion and Their Interrelationship by Fluid-Structure Interaction Finite Element Method.

Watanabe, Hiroshi; Hisada, Toshiaki; Sugiura, Seiryo; Okada, Junichi; Fukunari, Hiroshi

doi:10.1299/jsmec.45.1003

Cited by 60 publications

(52 citation statements)

References 19 publications

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“…Details of the formulations have been described in our previous reports (9) - (11) . Here, we briefly present the framework of the comprehensive simulation program based on finite element method.…”

Section: Model Frameworkmentioning

confidence: 99%

“…This analysis will be termed "structure only analysis" hereafter. For precise formulation, see previous study (9) . 2.…”

Section: Model Frameworkmentioning

confidence: 99%

“…2 FE model of normal LV and its loading conditions Although it is an essential requirement for FE analysis to determine the mesh of an object based on the initial shape in an undeformed state under stress-free conditions, it is difficult to know this for a living human LV. In the previous study (9) - (11) as well as in this study, we estimated the initial shape of LV from MR images of adult human LV at end-diastole by applying an appropriate negative pressure to it so that the volume becomes 60 × 10 3 mm 3 . This process was done only to make an initial finite element mesh under stress-free state.…”

Section: Model Frameworkmentioning

confidence: 99%

“…These are: intra-ventricular and aortic pressures and the ventricular pressure-volume relation during the cardiac cycle (9) , rotation and vertical displacement of the ventricle (10) , diastolic flow propagation velocity obtained from the flow mapping (11) . All of these comparisons demonstrated good agreement thus supporting the validity of this model.…”

Section: Simulationmentioning

confidence: 99%

“…We have already developed a finite element model of the left ventricle based on the molecular mechanisms of cardiac excitation-contraction (9) - (11) . Because, in these analyses, both structure (ventricular wall) and fluid (blood) were simulated by fluid-structure interaction analysis (11) , we could examine the relation between the structure and function of cardiac tissue and hemodynamic parameters in detail.…”

Section: Introductionmentioning

confidence: 99%

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Finite Element Analysis of Ventricular Wall Motion and Intra-Ventricular Blood Flow in Heart with Myocardial Infarction

Sugano

Sugiura

Hisada

2004

JSME Int. J., Ser. C

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To study the wall motion abnormality and characteristic flow distribution observed in the heart with myocardial infarction, we modified our finite element model of left ventricle and performed simulations at two different phases after the onset of the disease by applying characteristic material property to the infarcted region. The model could not only reproduce the hemodynamic change in myocardial infarction but also give mechanistic insight into the following complicating problems. 1) Stagnation of blood as the cause of clot formation 2) Extra energy wasted for the stretch of infarcted tissue. The effect of compensatory enhancement of the force generation in normal myocardial tissue is also discussed.

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Section: Model Frameworkmentioning

confidence: 99%

“…This analysis will be termed "structure only analysis" hereafter. For precise formulation, see previous study (9) . 2.…”

Section: Model Frameworkmentioning

confidence: 99%

Section: Model Frameworkmentioning

confidence: 99%

Section: Simulationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Finite Element Analysis of Ventricular Wall Motion and Intra-Ventricular Blood Flow in Heart with Myocardial Infarction

Sugano

Sugiura

Hisada

2004

JSME Int. J., Ser. C

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Fluid-solid coupling for the investigation of diastolic and systolic human left ventricular function

Nordsletten

McCormick

Kilner

et al. 2010

Int. J. Numer. Meth. Biomed. Engng.

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SUMMARYUnderstanding the underlying feedback mechanisms of fluid/solid coupling and the role it plays in heart function is crucial for characterizing normal heart function and its behavior in disease. To improve this understanding, an anatomically accurate computational model of fluid-solid mechanics in the left ventricle is presented which assesses both the passive diastolic and active systolic phases of the heart. Integrating multiple data which characterize the hemodynamical and tissue mechanical properties of the heart, a numerical approach was applied which allows non-conformity in an optimal finite element scheme (J. Comp. Phys., submitted; Fluid-solid coupling for the simulation of left ventricular mechanics, University of Oxford, 2009). This approach is applied to look specifically at left ventricular fluid/solid coupling, allowing quantitative assessment of blood flow through the left ventricle, pressure distributions, activation and the loss of mechanical energy due to viscous dissipation.

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Modelling left ventricular function under assist device support

McCormick

Nordsletten

Kay

et al. 2011

Int. J. Numer. Meth. Biomed. Engng.

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SUMMARYNumerical simulations provide a unique approach for investigating the impact of left ventricular assist devices (LVADs) on the pump function of the heart. To this end, the fictitious domain (FD) method was incorporated within a non-conforming coupled fluid-solid mechanics solver creating a model capable of capturing the full range of cardiac motion under LVAD support, including contact of the cannula with the ventricular wall. To demonstrate and verify the properties of the applied method, convergence studies were performed showing linear convergence for both a fluid only problem with an immersed rigid body, as well as a fluid-solid coupled problem with a fluid immersed rigid body interacting with the coupled elastic solid. The model was implemented on a left ventricular (LV) geometry constructed from human MRI data. Simulations were performed to compare LV function with an FD prescribed LVAD cannula and with a cannula applied as a Dirichlet boundary. Good agreement was observed between the simulations for myocardial deformation, major flow features and rates of energy transfer. Finally, an LV simulation was performed to bring the ventricular wall into contact with the cannula, demonstrating the applicability of the model to investigating LV function under LVAD support.

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Computer Simulation of Blood Flow, Left Ventricular Wall Motion and Their Interrelationship by Fluid-Structure Interaction Finite Element Method.

Cited by 60 publications

References 19 publications

Finite Element Analysis of Ventricular Wall Motion and Intra-Ventricular Blood Flow in Heart with Myocardial Infarction

Finite Element Analysis of Ventricular Wall Motion and Intra-Ventricular Blood Flow in Heart with Myocardial Infarction

Fluid-solid coupling for the investigation of diastolic and systolic human left ventricular function

Modelling left ventricular function under assist device support

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