Computer simulation of electrospinning. Part I. Effect of solvent in electrospinning

Lu, Chun; Chen, Ping; Li, Jianfeng; Zhang, Yujun

doi:10.1016/j.polymer.2005.11.090

Cited by 70 publications

(43 citation statements)

References 31 publications

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“…Among the electrospinning process parameters examined, the applied electric potential had an effect on electrospinning in terms of fiber jet formation, bead defects and fiber diameter [61, 76–77]. For example, fiber jets were induced when an electric field of 4 kV/cm was used to spin B. mori silk solution (8%, w/v) in formic acid, while fibers were not able to form when a lower electric field of 3 kV/cm was used [78].…”

Section: Electrospinning Silk Proteinsmentioning

confidence: 99%

Electrospun silk biomaterial scaffolds for regenerative medicine

Zhang

Reagan

Kaplan

2009

Advanced Drug Delivery Reviews

402

274

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Electrospinning is a versatile technique that enables the development of nanofiber-based biomaterial scaffolds. Scaffolds can be generated that are useful for tissue engineering and regenerative medicine since they mimic the nanoscale properties of certain fibrous components of the native extracellular matrix in tissues. Silk is a natural protein with excellent biocompatibility, remarkable mechanical properties as well as tailorable degradability. Integrating these protein polymer advantages with electrospinning results in scaffolds with combined biochemical, topographical and mechanical cues with versatility for a range of biomaterial, cell and tissue studies and applications. This review covers research related to electrospinning of silk, including process parameters, post treatment of the spun fibers, functionalization of nanofibers, and the potential applications for these material systems in regenerative medicine. Research challenges and future trends are also discussed.

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Section: Electrospinning Silk Proteinsmentioning

confidence: 99%

Electrospun silk biomaterial scaffolds for regenerative medicine

Zhang

Reagan

Kaplan

2009

Advanced Drug Delivery Reviews

402

274

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“…Scaffolds for cell growth are produced from nanofibrous mats made of these materials using the solution-electrospinning method. 6,7 However, residual solvent in fibers is not favorable for medical applications. Therefore, we devised a melt-electrospinning system, which has no issues related to solvent, and used it to make fibers from poly(lactide) and poly(ethylene-co-vinyl alcohol).…”

Section: Introductionmentioning

confidence: 99%

Melt‐electrospinning of poly(ethylene terephthalate) and polyalirate

Ogata

Shimada

Yamaguchi

et al. 2007

J of Applied Polymer Sci

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Rodlike polymer samples were made from three kinds of poly(ethylene terephthalate) (PET) pellets with different intrinsic viscosities (IV), and from polyalirate (Vectra) pellets. PET and Vectra fibers were produced using a melt-electrospinning system equipped with a CO 2 -laser melting device from these rodlike samples. The effects of IV value and laser output power on the fiber diameter of PET were investigated. Furthermore, the effect of the laser output power on the fiber diameter of Vectra was investigated. The crystal orientation of these produced fibers was also investigated by X-ray photographs. The following conclusions were reached: (i) the diameter of PET fiber decreases with increasing laser output power; (ii) the minimum average diameter of PET fibers is scarcely influenced by the value of IV; (iii) the electrospun PET fibers show isotropic crystal orientation; (iv) fibers having an average fiber diameter smaller than 1 mm cannot be obtained from PET and Vectra using the system developed; and (v) preferred liquid crystal orientation can be seen in electrospun Vectra fibers.

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“…In the past, several research groups have been actively working in this field. [4][5][6][7][8][9] Both process and fluid parameters affecting the size and morphology of the electrospun fibers have been reported. These parameters include solution surface tension, viscosity, net charge density, conductivity, dielectric constant, and electric field strength.…”

Section: Introductionmentioning

confidence: 99%

“…The word 'throughput' used in their paper is similar to our definition of electrospinnability, except that electrospinnability excludes nonspinnable droplets. For the effects of solvents, Lu et al [8] studied the influence of solvents on the morphology of the electrospun ethylene/vinyl alcohol copolymer. They found that solvents with strong molecular interactions with polymer produced bigger fibers than solvents with flexible chains.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Solvent Properties and Functionality on the Electrospinnability of Polystyrene Nanofibers

Pattamaprom

Hongrojjanawiwat

Koombhongse

et al. 2006

Macro Materials & Eng

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Summary: In order to produce nanometer‐sized fibers at an industrial scale, not only the morphology but also the production rate of fibers is important. The effect of solvent properties and functionality on the production rate of electrospun PS nanofibers was investigated using eighteen different solvents. The solution concentration was varied between 10 and 30% w/v. Electrospinning of PS solutions was carried out at various applied voltages and tip‐to‐collector distances The production rate of the obtained PS nanofibers was quantified in terms of electrospinnability. We found that the chance for the resulting PS solution to be spinnable is greater for solvents with high dipole moment and low viscosity. The solvent that provided the highest electrospinnability for polystyrene was DMF and the functionalities that promoted high dipole moment and thus high spinnability were the carbonyl group and the nitrogen group with free electrons. General guidelines for choosing suitable solvents for successful production of electrospun nanofibers have also been proposed.

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Computer simulation of electrospinning. Part I. Effect of solvent in electrospinning

Cited by 70 publications

References 31 publications

Electrospun silk biomaterial scaffolds for regenerative medicine

Electrospun silk biomaterial scaffolds for regenerative medicine

Melt‐electrospinning of poly(ethylene terephthalate) and polyalirate

The Influence of Solvent Properties and Functionality on the Electrospinnability of Polystyrene Nanofibers

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