Computer tomographic imaging in 4 dogs with primary nasal canine transmissible venereal tumor and differing cellular phenotype

Ojeda, Javier; Mieres, Marcelo; Soto, Francisco; Arnés, Verónica; Paredes, Enrique; Navarrete, María José

doi:10.1111/jvim.15125

Cited by 16 publications

(32 citation statements)

References 19 publications

(74 reference statements)

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“…In contrast to the genital form of TVT without sex predisposition, in publications concerning the nasal form males were more frequently affected [5] [26]. Our data confirms this finding, with 9 of 12 dogs being males.…”

Section: Discussionsupporting

confidence: 87%

Nasal transmissible venereal tumours in 12 dogs – a retrospective study

Абраменко¹,

Soto

Mueller

et al. 2020

Tierarztl Prax Ausg K Kleintiere Heimtiere

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Objective The aim of this study was a retrospective analysis of clinical manifestation and treatment outcome of the nasal form of transmissible venereal tumours (TVT). Material and methods Twelve dogs suffering from nasal TVT were included in this study. Patients with primary genital lesions were excluded from the study. Signalment, physical examination and laboratory findings, results of further diagnostics, and treatment results were recorded in all patients. Results The study population comprised 9 male and 4 female dogs with an (estimated) age ranging from 3 to 7 years. With one exception all dogs originated from Ukraine. Symptoms of nasal TVT included sneezing, nasal bleeding (all cases), skull infiltration (9 cases), oronasal fistulas (9 cases) and cutaneous fistulas (5 cases). Animals received vincristine sulfate at 0.7 mg/m2 i. v. weekly. The treatment course consisted of 4–9 cycles (median 5 cycles). Complete remission was achieved in all cases. All dogs were disease-free during the follow-up period (median 23.5 months, range 12–56 months). All patients tolerated the treatment very well. Clinical significance In conclusion, our data suggest that nasal TVT can have a good response to vincristine treatment. TVT should be considered as a differential diagnosis in sneezing dogs with nasal discharge or bleeding especially in young dogs and in dogs with suspected nasal tumours, even in countries without a stray animal population.

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Section: Discussionsupporting

confidence: 87%

Nasal transmissible venereal tumours in 12 dogs – a retrospective study

Абраменко¹,

Soto

Mueller

et al. 2020

Tierarztl Prax Ausg K Kleintiere Heimtiere

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“…Segundo Lima et al (2011), Ganguly et al (2013) e Ferreira et al (2017, o prepúcio e a base do pênis são as regiões mais frequentes de acometimento pelo TVT em machos; por outro lado, em fêmeas a região mais acometida pela neoplasia é vestíbulo vaginal, seguido pela região vaginal (Ganguly et al, 2013), contrapondo os resultados do presente trabalho. O tamanho dos TVTs permaneceu dentro dos limites referenciados pela literatura (Otter et al, 2015;Marroquín et al, 2018;Ojeda et al, 2018), variando entre 0,4 e 5,5 cm.…”

Section: Discussionunclassified

Estudo retrospectivo de tumor venéreo transmissível em cães (Canis lupus familiaris) na região de Garça, São Paulo, Brasil

et al. 2021

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O objetivo do trabalho foi realizar um estudo retrospectivo do Tumor Venéreo Transmissível (TVT) em cães na região de Garça - São Paulo (SP), no período de 2012 a 2016, por meio de estudo das variáveis existentes. Foram analisados os dados das fichas clínico-cirúrgicas de clínicas veterinárias da região, do período de janeiro de 2012 a julho de 2016. As variáveis incluíram sexo, idade, raça, massa corpórea, cães submetidos ou não à contracepção cirúrgica, acesso livre à rua, exames laboratoriais sanguíneos, localização e tamanho do TVT, e o tipo e a duração do tratamento. Foram diagnosticados 20 cães com TVT, 80% fêmeas e 20% machos, com maior incidência em cães com idade acima de seis anos, sem raça definida (SRD), com massa corpórea entre nove e 15 kg, não submetidos à contracepção cirúrgica e com acesso livre à rua. Todos os cães apresentaram leucocitose e linfocitose. Nos machos, o TVT foi observado somente no prepúcio (20%); e nas fêmeas a região mais acometida foi a vaginal (45%). TVTs com tamanho entre 1 e 3 cm foram os mais incidentes (50%). O protocolo de tratamento mais usado foi o sulfato de vincristina a cada sete dias (60%) com uma média de 3,7 ± 1,5 aplicações, seguido da associação com doxiciclina em casos positivos de erliquiose. Concluiu-se que as cadelas adultas não castradas, da raça SRD de porte médio, e com acesso livre à rua foram as que apresentaram maior incidência do TVT e o protocolo de tratamento foi com sulfato de vincristina.

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“…CTVT cells have the particularity of implanting in the mucous membranes, when they lose integrity (STOCKMANN et al, 2011), in a way that the tumor is established, proliferates, and may even develop metastases (OJEDA et al, 2018). Once established, the clinical manifestation may range from a solitary formation to multiple lobes, preferably on the external genitalia (SANTOS et al, 2005).…”

Section: Clinic and Surgerymentioning

confidence: 99%

Do alterations in gene expressions influence tumorigenesis in the transmissible venereal tumor in dogs?

et al. 2020

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Canine transmissible venereal tumor (CTVT) is a transmissible neoplasm, which spreads naturally between dogs through the halogenic transfer of tumor cells, mainly during coitus. It is the oldest known tumoral lineage in nature and reports on gene mutations have been extended. Also, this tumor shares several genetic mutations with some cancers in humans, among them lung carcinomas, melanoma, prostate, breast, among other cancers. Thus, expression of tumor suppressor genes such as TP53, P21, and apoptosis-related genes such as BAX, BCL-2, and BCL-xL, both in vivo and in vitro (primary cell culture) were quantified. In the present study, the comparison of gene expression, the TP53 gene, in most cases, was shown to be high in the majority of tissues (65%) and primary cell culture (100%), while BCL-2, BCL-xL, and BAX presented variation among the animals analyzed. Moreover, in these situations, the results suggested that the apoptotic regulation of these genes did not occur for TP53. The P21 gene was shown to be mostly normal (70%); although, absence (6%) and underexpressions (24%) were also observed. Statistical analysis of the BCL-xL gene demonstrated significant differences between the tissues of the animals when compared to the cell cultures; however, to the other genes, no statistical difference was observed between the groups. Preliminarily, the results suggested the presence of alterations in the gene expressions of the TP53, P21, BAX, BCL-2 and BCL-xL leading to loss of function in these genes, which affect the tumorigenesis of CTVT.

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Computer tomographic imaging in 4 dogs with primary nasal canine transmissible venereal tumor and differing cellular phenotype

Cited by 16 publications

References 19 publications

Nasal transmissible venereal tumours in 12 dogs – a retrospective study

Nasal transmissible venereal tumours in 12 dogs – a retrospective study

Estudo retrospectivo de tumor venéreo transmissível em cães (Canis lupus familiaris) na região de Garça, São Paulo, Brasil

Do alterations in gene expressions influence tumorigenesis in the transmissible venereal tumor in dogs?

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