Computerized Tomography Guided Percutaneous Ethanol Injection for the Treatment of Hyperfunctioning Pheochromocytoma

Wang, Peijun; Zuo, Chuantao; Qian, Zhenghong; Tian, Jie; Ren, Fangyuan; Zhou, Dajing

doi:10.1097/01.ju.0000081145.44969.b8

Cited by 15 publications

(9 citation statements)

References 6 publications

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“…We agree with experiences of other authors [16] in that laparoscopic transperitoneal adrenalectomy in pediatrics is safe and to be effective alternative for open surgery in experienced hands. Wang et al [17] described their experience in managing functioning pheochromocytoma by percutaneous ethanol injection in an adult population and reported a safe and effective procedure. We applied this type of management in a single patient with bilateral disease.…”

Section: Discussionmentioning

confidence: 99%

Surgical analysis of pediatric and adolescent sporadic pheochromocytoma: single center experience

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Surgical analysis of pediatric and adolescent sporadic pheochromocytoma: single center experience

et al. 2011

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“…This procedure could also be used in CT-guided acetic acid injection for liver tumors [30,31] , ethanol injection for adrenal tumors [32] , and thymus ethanol injection for myasthenia gravis [33] .…”

Section: Discussionmentioning

confidence: 99%

CT-guided percutaneous ethanol injection with disposable curved needle for treatment of malignant liver neoplasms and their metastases in retroperitoneal lymph nodes

Zuo¹,

Wang²,

Shao³

et al. 2004

WJG

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AIM:To explore the feasibility of computed tomography (CT)-guided percutaneous ethanol injection (PEI) using a disposable curved needle for treatment of malignant liver neoplasms and their metastases in retroperitoneal lymph nodes. METHODS:CT-guided PEI was conducted using a disposable curved needle in 26 malignant liver tumors smaller than 5 cm in diameter and 5 lymph node metastases of liver cancer in the retroperitoneal space. The disposable curved needle was composed of a straight trocar (21G) and stylet, a disposable curved tip (25 G) and a fine stylet. For the tumors found in deep sites and difficult to reach, or for hepatic masses inaccessible to the injection using a straight needle because of portal vein and bile ducts, the straight trocar was used at first to reach the side of the tumor. Then, the disposable curved needle was used via the trocar. When the needle reached the tumor center, appropriate amount of ethanol was injected. For relatively large malignant liver tumors, multi-point injection was carried out for a better distribution of the ethanol injected throughout the masses. The curved needle was also used for treatment of the metastasis in retroperitoneal lymph nodes blocked by blood vessels and inaccessible by the straight needle. RESULTS:All of the 26 liver tumors received 2 or more times of successful PEI, through which ethanol was distributed throughout the whole tumor mass. Effect of the treatment was monitored by contrast-enhanced multi-phase CT and magnetic resonance imaging (MRI) examinations three months later. Of the 18 lesions whose diameters were smaller than 3 cm, the necrotic change across the whole mass and that in most areas were observed in 15 and 3 tumors, respectively. Among the 8 tumors sizing up to 5 cm, 5 were completely necrotic and 3 largely necrotic. Levels of tumor seromarkers were significantly reduced in some of the cases. In 5 patients with metastases of liver cancer in retroperitoneal lymph nodes who received 1 to 3 times of PEI, all the foci treated were completely necrotic and smaller demonstrated by dynamic contrast-enhanced CT or MRI 3 months later.CONCLUSION: CT-guided PEI using a disposable curved needle is effective, time-saving and convenient, providing an alternative therapy for the treatment of malignant liver tumors and their retroperitoneal lymph node metastases.Zuo CJ, Wang PJ, Shao CW, Wang MJ, Tian JM, Xiao Y, Ren FY, Hao XY, Yuan M. CT-guided percutaneous ethanol injection with disposable curved needle for treatment of malignant liver neoplasms and their metastases in retroperitoneal lymph nodes.

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“…In addition, successful results have been reported for percutaneous injection of ethanol into hepatocellular carcinoma. Ethyl alcohol has also been used to treat thyroid cysts, hyperparathyroidism, benign prostate hypertrophy, and pheochromocytoma of the adrenal gland [8,10,27].…”

Section: Discussionmentioning

confidence: 99%

Surgical treatment of giant cell tumour of long bone with anhydrous alcohol adjuvant

Yoon

Lee

et al. 2006

International Orthopaedics (SICOT)

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This study was designed to evaluate the feasibility and effectiveness of the use of anhydrous alcohol as an adjuvant treatment for giant cell tumours (GCTs) of long bone. Between October 1989 and January 2004, 42 GCT patients were treated and followed up for an average of 4.1 years (range 1-13 years). Mean patient age was 34 years (range 17-67 years). After curettage and additional burring, anhydrous alcohol was used as an adjuvant therapy in all patients before the bone defect was filled with bone graft or cement. Four patients (9.5%) experienced local recurrence. There were no alcohol-related complications. Recurrence-free probability was 87.6% at final follow-up (13 years) after index surgery by Kaplan-Meyer analysis. Our data suggest that anhydrous alcohol can be used as an effective safe adjuvant for the treatment of GCT of long bone.

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Computerized Tomography Guided Percutaneous Ethanol Injection for the Treatment of Hyperfunctioning Pheochromocytoma

Abstract: The therapeutic efficacy of CT guided PEI for hyperfunctioning pheochromocytoma is definite and worth widespread application because the procedure is safe, microtraumatic and less costly, and has low morbidity.

Cited by 15 publications

References 6 publications

Surgical analysis of pediatric and adolescent sporadic pheochromocytoma: single center experience

Surgical analysis of pediatric and adolescent sporadic pheochromocytoma: single center experience

CT-guided percutaneous ethanol injection with disposable curved needle for treatment of malignant liver neoplasms and their metastases in retroperitoneal lymph nodes

Surgical treatment of giant cell tumour of long bone with anhydrous alcohol adjuvant

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