Computerized tumor-infiltrating lymphocytes density score predicts survival of patients with resectable lung adenocarcinoma

Pan, Xipeng; Lin, Huan; Han, Chu; Feng, Zhengyun; Wang, Yumeng; Lin, Jiatai; Qiu, Bingjiang; Yan, Li; Li, Bingbing; Xu, Zeyan; Wang, Zhizhen; Zhao, Ke; Liu, Zhenbing; Liang, Changhong; Chen, Xin; Li, Zhenhui; Cui, Yanfen; Lu, Cheng; Liu, Zaiyi

doi:10.1016/j.isci.2022.105605

Cited by 25 publications

(16 citation statements)

References 43 publications

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“…In colorectal cancer the presence of specific T cell populations within the tumour microenvironment has been shown to correlate with survival ( 17 ) which has in turn led to the development of an immune score to aid with the staging of colorectal cancer ( 18 , 19 ). Similar findings have been seen in lung cancer, where the density of tumour infiltrating lymphocytes in resectable adenocarcinoma has been associated with improved survival ( 20 ). Additionally, in lung cancer and melanoma, the presence of tumour infiltrating lymphocytes and increased gene expression for CD4 and CD8 was found to correlate with improved survival in those patients treated with immunotherapy ( 21 ).…”

Section: Introductionsupporting

confidence: 75%

Methods for assessment of the tumour microenvironment and immune interactions in non-small cell lung cancer. A narrative review

et al. 2023

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Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer death worldwide. Immunotherapy with immune checkpoint inhibitors (ICI) has significantly improved outcomes in some patients, however 80-85% of patients receiving immunotherapy develop primary resistance, manifesting as a lack of response to therapy. Of those that do have an initial response, disease progression may occur due to acquired resistance. The make-up of the tumour microenvironment (TME) and the interaction between tumour infiltrating immune cells and cancer cells can have a large impact on the response to immunotherapy. Robust assessment of the TME with accurate and reproducible methods is vital to understanding mechanisms of immunotherapy resistance. In this paper we will review the evidence of several methodologies to assess the TME, including multiplex immunohistochemistry, imaging mass cytometry, flow cytometry, mass cytometry and RNA sequencing.

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Section: Introductionsupporting

confidence: 75%

Methods for assessment of the tumour microenvironment and immune interactions in non-small cell lung cancer. A narrative review

et al. 2023

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“…Therefore, mature TLS is proven to prevent LN metastasis 47 Therefore, computerized TLS density have been used to evaluate prognosis of lung adenocarcinoma. 104 Neoadjuvant chemotherapy has achieved good effect in NSCLC, while the intrinsic mechanism has remained unclear. A phase 2 NeoCOAST Platform Trail reported that markers of TLS maturation are associated with major pathological response of NSCLC patients treated with neoadjuvant.…”

Section: Tls-related Immune Responses In Lung Cancermentioning

confidence: 99%

“…recently reported that tumor‐derived LNs metastasis reduced TLS maturation and GC formation and was associated with poor prognosis, diminished B cell differentiation and weakened interferon (IFN)‐γ response. Therefore, mature TLS is proven to prevent LN metastasis 47 Therefore, computerized TLS density have been used to evaluate prognosis of lung adenocarcinoma 104 …”

Section: Role Of Tls In Cancermentioning

confidence: 99%

Tertiary lymphoid structures in cancer: immune mechanisms and clinical implications

Wang,

et al. 2024

MedComm

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Cancer is a major cause of death globally, and traditional treatments often have limited efficacy and adverse effects. Immunotherapy has shown promise in various malignancies but is less effective in tumors with low immunogenicity or immunosuppressive microenvironment, especially sarcomas. Tertiary lymphoid structures (TLSs) have been associated with a favorable response to immunotherapy and improved survival in cancer patients. However, the immunological mechanisms and clinical significance of TLS in malignant tumors are not fully understood. In this review, we elucidate the composition, neogenesis, and immune characteristics of TLS in tumors, as well as the inflammatory response in cancer development. An in‐depth discussion of the unique immune characteristics of TLSs in lung cancer, breast cancer, melanoma, and soft tissue sarcomas will be presented. Additionally, the therapeutic implications of TLS, including its role as a marker of therapeutic response and prognosis, and strategies to promote TLS formation and maturation will be explored. Overall, we aim to provide a comprehensive understanding of the role of TLS in the tumor immune microenvironment and suggest potential interventions for cancer treatment.

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“…The Recursive Separated and Weighted Histogram Equalization (RSWHE) [14] algorithm splits an input histogram into more than two sub-histograms recursively based on the mean or median of the sub-image to modify the sub-histogram by a normalized power-law function and then equalizes the weighted sub-histogram. It can keep remarkable brightness and enhances the contrast but easily produces artifacts [15,16] in the image.…”

Section: Introductionmentioning

confidence: 99%

An Effective Method of Infrared Maritime Target Enhancement and Detection with Multiple Maritime Scene

et al. 2023

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Aiming at maritime infrared target detection with low contrast influenced by maritime clutter and illumination, this paper proposes a Modified Histogram Equalization with Edge Fusion (MHEEF) pre-processing algorithm in backlight maritime scenes and establishes Local-Contrast Saliency Models with Double Scale and Modes (LCMDSM) for detecting a target with the properties of positive and negative contrast. We propose a local-contrast saliency mathematical model with double modes in the extension of only one mode. Then, the big scale and small scale are combined into one Target Detection Unit (TDU), which can approach the “from bottom to up” mechanism of the Visual Attention Model (VAM) better and identify the target with a suitable size, approaching the target’s actual shape. In the experimental results and analysis, clutter, foggy, backlight, and dim maritime scenes are chosen to verify the effectiveness of the target detection algorithm. From the enhancement result, the LCMDSM algorithm can achieve a Detection Rate (DR) with a value of 98.26% under each maritime scene on the average level and can be used in real-time detection with low computational cost.

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Computerized tumor-infiltrating lymphocytes density score predicts survival of patients with resectable lung adenocarcinoma

Cited by 25 publications

References 43 publications

Methods for assessment of the tumour microenvironment and immune interactions in non-small cell lung cancer. A narrative review

Methods for assessment of the tumour microenvironment and immune interactions in non-small cell lung cancer. A narrative review

Tertiary lymphoid structures in cancer: immune mechanisms and clinical implications

An Effective Method of Infrared Maritime Target Enhancement and Detection with Multiple Maritime Scene

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