COMT Val158Met genotype is associated with fluctuations in working memory performance: converging evidence from behavioural and single-trial P3b measures

Elevated P3b latency variability in carriers of ZNF804A risk allele for psychosis

“…Both behavioural ISV (Kuntsi et al, 2006) and its neural correlates (McLoughlin et al, 2014) have been shown to be heritable traits in twin studies, and there is also evidence for specific genetic polymorphisms being linked to ISV (Saville et al, 2014b), which we corroborate here. We found a genetic association with neural, but not behavioural ISV, suggesting that these phenotypes should be assessed separately to identify overlapping and non-overlapping genetic contributions.…”

“…The procedure used in Saville et al (2011Saville et al ( , 2012Saville et al ( , 2014aSaville et al ( , 2014b was used for single-trial analysis. Average stimulus-locked ERPs for all participants were concatenated along the time-axis, and spatial principal component analysis was run on these data using the ERP-PCA toolkit (Dien, 2010).…”

“…Finally, testing for group effects on accuracy is important to assess whether speed-accuracy tradeoffs are a plausible explanation for other group differences. As accuracy scores have been shown to be substantially skewed in this paradigm, due to truncation by a ceiling effect (Saville et al, 2014b), we used a non-parametric bootstrapping approach for these data, implemented using the ezBoot function in the 'ez' package for R (Lawrence, 2013). Participants' accuracy scores were sampled randomly with replacement 10,000 times per cell of the analysis (i.e.…”

Genetic correlates of the development of theta event related oscillations in adolescents and young adults

“…From ages 6 to 20 there is an age reversal in the genotypic effects on performance in a working memory task and a corresponding variation in the activation level of of the right inferior frontal gyrus and intraparietal sulcus (Dumontheil et al, 2011). These variants have effects on auditory evoked potentials in adults (Heitland et al, 2013; Saville et al, 2014). In 9 year olds, effects on IQ and executive function are found only in males, and are stronger in in pubertal than in prepubertal males (Barnett et al, 2007).…”

Variability of single trial brain activation predicts fluctuations in reaction time

“…In our sample, DAT1 interacted with psychosocial adversity with respect to reaction time variability but not with respect to intertrial coherence, topographic consistency or low frequency amplitude variability. A recent study showed that catechol-o-methyltransferase (COMT) genotype was associated with the amount of latency jitter in single-trial P3b and working memory performance (Saville et al, 2014).…”