Con A lectin binding by synthetic bivalent arabinomannan tri- and pentasaccharides reveals connectivity-dependent functional valencies

Parija, Ipsita; Yadav, Shivender; Jayaraman, Narayanaswamy

doi:10.1016/j.carres.2024.109050

Cited by 1 publication

(1 citation statement)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As sources for Con A, either the isolation from Jack beans (Canavalia ensiformis) [23,55] or biosynthesis [56] can be considered. The purification of Con A involves firstly the cleaning of the seeds followed by grinding them to a fine powder.…”

Section: Origin Structure and Functions Of Concanavalin Amentioning

confidence: 99%

Recent Insights into Glucose-Responsive Concanavalin A-Based Smart Hydrogels for Controlled Insulin Delivery

Bercea,

Lupu

2024

Gels

View full text Add to dashboard Cite

Many efforts are continuously undertaken to develop glucose-sensitive biomaterials able of controlling glucose levels in the body and self-regulating insulin delivery. Hydrogels that swell or shrink as a function of the environmental free glucose content are suitable systems for monitoring blood glucose, delivering insulin doses adapted to the glucose concentration. In this context, the development of sensors based on reversible binding to glucose molecules represents a continuous challenge. Concanavalin A (Con A) is a bioactive protein isolated from sword bean plants (Canavalia ensiformis) and contains four sugar-binding sites. The high affinity for reversibly and specifically binding glucose and mannose makes Con A as a suitable natural receptor for the development of smart glucose-responsive materials. During the last few years, Con A was used to develop smart materials, such as hydrogels, microgels, nanoparticles and films, for producing glucose biosensors or drug delivery devices. This review is focused on Con A-based materials suitable in the diagnosis and therapeutics of diabetes. A brief outlook on glucose-derived theranostics of cancer is also presented.

show abstract

Section: Origin Structure and Functions Of Concanavalin Amentioning

confidence: 99%