Concentration of high-sensitivity cardiac troponin I in the oral fluid in patients with acute myocardial infarction: a pilot study

Chaulin, Aleksey M.; Дуплякова, П. Д.; Bikbaeva, G. R.; Тухбатова, А. А.; Григорьева, Э. В.; Дупляков, Д. В.

doi:10.15829/1560-4071-2020-3814

Cited by 51 publications

(45 citation statements)

References 13 publications

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“…Однако с появлением новых высокочувствительных методов определения (hs-cTnI и hs-cTnT) данные представления претерпели изменения. Было показано, что современные высокочувствительные методы иммуноанализа позволяют определять сердечные тропонины абсолютно у всех здоровых индивидуумов не только в крови [3,5], но и других биологических жидкостях, таких как моча [6], слюна [7][8][9].…”

Section: Introductionunclassified

High-sensitivity cardiac troponins: circadian rhythms

Chaulin

Дупляков

2021

Cardiovasc Ther Prev

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High-sensitivity cardiac troponins (hs-cTnI and hs-cTnT) contribute to a progression in the diagnosis and treatment of cardiovascular diseases: acceleration of diagnosis of acute myocardial infarction (early diagnostic algorithms: 0-1 h, 0-3 h), and earlier initiation of optimal treatment, expansion of diagnostic and prognostic potential (earlier detection of myocardial damage during chemotherapy, endocarditis, myocarditis and other diseases). However, increased sensitivity slightly reduced the specificity and created the need for a more thorough interpretation of elevated levels of hs-cTnI and hs-cTnT in a number of pathologies that damage cardiomyocytes. In addition, there was a need to introduce reference levels of hs-cTnI and hs-cTnT (99 percentile), taking into account sex. Recently, there has also been information about circadian (diurnal) variations in hs-cTnT and hs-cTnI levels. We analyze in detail the results of clinical studies that found circadian changes in hs-cTnI and hs-cTnT. Possible mechanisms underlying these changes in hs-cTnT and hs-cTnI concentrations are discussed.

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Section: Introductionunclassified

High-sensitivity cardiac troponins: circadian rhythms

Chaulin

Дупляков

2021

Cardiovasc Ther Prev

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“…In a number of CVDs including AMI, heart failure and AH it is possible to use human body fluids including oral fluid (saliva) and urine obtained by noninvasive methods as an alternative diagnostic approach. 96 , 107–112 Several recent studies using modern immunoassays have shown that hs-cTnI 107 , 108 and brain natriuretic peptide 110 levels in the saliva of patients with AMI and heart failure are higher than in the control group, respectively. These works prove the existence of the mechanism for elimination of these cardiac markers molecules through the blood–salivary barrier.…”

Section: On New Possibilities For Study Hs-ctnt and Hs-ctni Levels In Body Fluids In Ah And Hc Obtained By Noninvasive Methodsmentioning

confidence: 99%

Clinical and Diagnostic Value of Highly Sensitive Cardiac Troponins in Arterial Hypertension

Chaulin¹

2021

VHRM

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In modern laboratory diagnostics of cardiovascular diseases (CVD), there is a clear tendency toward an increase in the sensitivity of methods for determining key CVD biomarkers, among which highly sensitive cardiac troponins (hs-Tn) deserve special attention. The introduction of the latter into clinical practice made it possible not only to improve the early diagnosis of acute myocardial infarction but also to open up a number of additional valuable opportunities for the use of hs-Tn, including the assessment of the risk of developing CVD in a healthy population, detection and monitoring of early myocardial injuries in the early stages of CVD development (for example, with ischemic heart disease and arterial hypertension), with noncardiac pathologies (for example, sepsis, chronic obstructive pulmonary disease, chronic renal failure, stroke, cancer, etc), and diagnostics of CVD by using biological fluids that can be obtained by noninvasive methods. This article discusses in detail the diagnostic value of hs-Tn in serum and urine in cases of arterial hypertension. Also, the paper pays considerable attention to the consideration of the mechanisms underlying the increase in hs-Tn in serum and urine in cases of arterial hypertension.

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“…In addition to urine, oral fluid is also planned to be used for non-invasive diagnostics. [77][78][79] The following can be noted as the advantages of non-invasive determination: 1) obtaining the biomaterial from patients is atraumatic and painless, and does not lead to anemisation of patients during repeated sampling of biomaterial for research, 2) the risk of bloodborne diseases (HIV, viral hepatitis, etc.) is reduced, 3) no trained medical personnel are required to obtain biological samples and the biomaterial can be sampled by the patient himself at home.…”

Section: Some New Data On Troponin Biochemistry and Diagnostic Capabilities Of High-sensitivity Troponin Assaysmentioning

confidence: 99%

“…The study of hs-cTnI and hs-cTnT molecules in biofluids obtained by non-invasive methods, in particular, in urine and oral fluid has very promising possibilities. [76][77][78] However, the existing studies are still insufficient to fully understand their practical significance for the laboratory diagnosis of CVD and there is an urgent need for further research.…”

Section: Some Directions For Future Researchmentioning

confidence: 99%

Cardiac Troponins: Contemporary Biological Data and New Methods of Determination

Chaulin¹

2021

VHRM

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Laboratory diagnosis plays one of the key roles in the diagnosis of many diseases, including cardiovascular diseases (CVD). The methods underlying the in vitro study of many CVD biomarkers, including cardiac troponins (cTnI and cTnT), are imperfect and are continually being improved to enhance their analytical performance, with sensitivity and specificity being the most important. Recently developed improved cTnI and cTnT detection methods, referred to as highly sensitive methods (hs-cTnI, hs-cTnT), have changed many of our ideas about the biology of cardiac troponins and opened up a number of additional diagnostic capabilities for practical healthcare. This article systematizes some relevant data on the biology of cardiac troponins as well as on methods for determining cTnI and cTnT with an analysis of the diagnostic value of their analytical characteristics (limit of blank, limit of detection, 99th percentile, coefficient of variation, and others). Data on extracardiac expression of cTnI and cTnT, mechanisms of formation and potential clinical significance of gender, age, and circadian characteristics of hs-cTnI and hs-cTnT content in serum are discussed. Considerable attention is paid to the discussion of new diagnostic capabilities of hs-cTnI, hs-cTnT, including consideration of promising possibilities for their study in biological fluids that can be obtained by non-invasive methods. Also, some possibilities of using hs-cTnI and hs-cTnT as prognostic laboratory biomarkers in healthy people (for example, to assess the risk of developing CVD) and in patients suffering from a number of pathological conditions that cause damage to cardiomyocytes are examined, and the potential mechanisms underlying the increase in hs-cTnI and hs-cTnT are discussed.

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Concentration of high-sensitivity cardiac troponin I in the oral fluid in patients with acute myocardial infarction: a pilot study

Cited by 51 publications

References 13 publications

High-sensitivity cardiac troponins: circadian rhythms

High-sensitivity cardiac troponins: circadian rhythms

Clinical and Diagnostic Value of Highly Sensitive Cardiac Troponins in Arterial Hypertension

Cardiac Troponins: Contemporary Biological Data and New Methods of Determination

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