Concentrations of free radicals and beta-endorphins in repeat breeder cows

Rizzo, Annalisa; Minoia, Giuseppe; Trisolini, Carmelinda; Manca, R.; Sciorsci, Raffaele Luigi

doi:10.1016/j.anireprosci.2006.08.013

Cited by 28 publications

(25 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…at Day 12; 56.53 6 1.96 (U.Carr; mean 6 s.e.m.) at Day 16; Rizzo et al, 2007). Thus, ROS production, which is known to accompany steroidogenesis (Sugino, 2006), is lower than the one occurring during the intense metabolic changes characterizing NEBAL (Albera and Kankofer, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…As a consequence, the maintenance of an equilibrium between ROS and antioxidants is crucial, above all in such a critical period of the dairy cow, as its abruption may also contribute to the outcome of many postpartum pathologies, which imply a prolongation of calving-first oestrus and calving-conception intervals and, consequently, economic losses (Kankofer, 2001;Rizzo et al, 2007 and.…”

Section: Discussionmentioning

confidence: 99%

“…The increase in ROS generation likely to occur around calving may overwhelm the antioxidant potential of the bovine maternal organism, making it prone to the development of many ROS-related alterations (Rizzo et al, 2007 and and infectious diseases such as mastitis (Malinowski and Gajewski, 2010).The leukocyte defences are depressed during the periparturient period. In particular, the neutrophil action could lead to inadequate clearance of the pathogens from the bovine udder (Contreras and Sordillo, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…This substance escapes rumen degradation and is metabolized in the intestinal mucosa to retinol and absorbed and transported to the liver with fat (Chew, 1987). This vitamin is also present in colostrum and milk at high levels (Calderó n et al, 2007) and is endowed with strong ROS-scavenging properties, which strengthen the resistance to infectious diseases, particularly mastitis (Przybylska et al, 2007).The increase in ROS generation likely to occur around calving may overwhelm the antioxidant potential of the bovine maternal organism, making it prone to the development of many ROS-related alterations (Rizzo et al, 2007 and and infectious diseases such as mastitis (Malinowski and Gajewski, 2010).The leukocyte defences are depressed during the periparturient period. In particular, the neutrophil action could lead to inadequate clearance of the pathogens from the bovine udder (Contreras and Sordillo, 2011).…”

mentioning

confidence: 99%

See 3 more Smart Citations

Evaluation of blood and milk oxidative status during early postpartum of dairy cows

Rizzo

Ceci

Pantaleo

et al. 2013

Animal

Self Cite

View full text Add to dashboard Cite

In dairy cows, the intensity of metabolic activity, associated with the negative energy balance (NEBAL), is responsible for an increased production of reactive oxygen species (ROS) and, subsequently, for the development of the condition of oxidative stress, which may overwhelm the antioxidant potential of the bovine maternal organism, making it prone to the development of many puerperal dysfunctions, as well as to an alteration of colostrum and milk quality. Given these premises, the aims of this study are to evaluate serum and milk concentrations of ROS and lipoperoxides, vitamins A and E, on the 10th, 12th, 14th and 16th day postpartum of dairy cows, a particularly critical period during which the NEBAL reaches its nadir, and to compare the trends of these parameters in two different bovine breeds. The study was performed in pluriparous Italian Friesian and Brown dairy cows. On the 10th day postpartum, all cows underwent a clinical examination to exclude the presence of alterations; furthermore, on the same day, a milk sample was collected from each cow, in order to perform the somatic cell count (SCC; (CE) N. 853/2004) and to establish which of them had an SCC <400 000/ml or .400 000/ml. In this study, among the 110 cows that were initially selected, the evaluation of these parameters allowed the inclusion of 80 animals, which were divided into four groups of 20 subjects each: Group F and F1: Italian Friesian healthy cows, with SCC <400 000/ml and .400 000/ml, respectively; Group B and B1: Italian Brown healthy cows, with SCC <400 000/ml and .400 000/ml, respectively. On the 10th, 12th, 14th and 16th day postpartum, peripheral blood and milk samples were collected. The results obtained show that in group B1 there were higher concentrations of ROS and milk antioxidants compared with Friesian group cows. This datum let us suppose that even in the presence of higher ROS concentrations the antioxidant status found in group B1 seems to be able to counteract the oxidative damage, which is more likely to develop in these cows.Keywords: dairy cow, postpartum, NEBAL, ROS, vitamins ImplicationsThis work investigates the physiological reactive oxygen species (ROS) and antioxidant concentrations in dairy cows between the 10th and the 16th day postpartum (peak of negative energy balance (NEBAL)) and highlights the importance of an adequate antioxidant system in dairy cows, particularly during NEBAL, in order to prevent and/or face the outcome of many postpartum pathologies and mastitis, which are easy to develop in such a critical period of the cow. The adequacy of an antioxidant support may thus reduce the economic losses and the prolongation of calving-first oestrus, calving-conception interval, related to the above-mentioned ROS-dependent alterations. IntroductionThe transition period is particularly critical to health, productivity and fertility of dairy cows (Leroy and Vanholder, 2008;Roche et al., 2009). In the last months of gestation, the cow experiences a reduction in dry matter intake (DMI), which continues...

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of blood and milk oxidative status during early postpartum of dairy cows

Rizzo

Ceci

Pantaleo

et al. 2013

Animal

Self Cite

View full text Add to dashboard Cite

show abstract

“…All kinds of stress factors cause excessive radical production in high milk-yielding cows. This may be a determining factor for the amount of progesterone synthesized by inhibiting luteal cell function [125,126]. In another study, the complex arrangement of antioxidant enzymes and compounds in the bovine CL was discussed.…”

Section: Relationship Between Progesterone and Oxidative Stress In Rumentioning

confidence: 99%

Clinical Use of Progesterone and Its Relation to Oxidative Stress in Ruminants

Kuru¹,

Kükürt²,

Oral³

et al. 2018

Sex Hormones in Neurodegenerative Processes and Diseases

View full text Add to dashboard Cite

Studies to determine the physiological effects and functions of progesterone started in the twentieth century. Progesterone is a steroid-structured hormone with 21 carbon atoms originating from cholesterol. The corpus luteum, formed after ovulation in ruminants, secretes progesterone, which plays a role in the continuity of the pregnancy. Progestagens can be used for estrus synchronization in cows and heifers. Similarly, they are used for estrus synchronization during the breeding season or outside the breeding season by taking advantage of the negative feedback effect of progesterone in small ruminants. It is applied for the treatment of embryonic deaths due to luteal insufficiency in cows with high milk yield. In anovulatory anestrus, exogenous progesterone applications can be very useful. Progesterone treatment contributes to the resolution of the anestrus by rearranging hypothalamic functions in cattle with follicular cysts. The oxidative stress index in the luteal phase, when progesterone is high in ruminants, is higher than in the follicular phase. In the critical period of pregnancy, a high index of oxidative stress-induced progesterone causes embryonic death. Factors that cause stress in high milk-yielding cows can affect the amount of progesterone synthesis by inhibiting luteal cell function due to excessive free radical production.

show abstract

Oxidative state in the estrus cycle of the buffaloes: a preliminary study

Sciorsci

Galgano

Mutinati³

et al. 2019

Trop Anim Health Prod

Self Cite

View full text Add to dashboard Cite

The oxidative status, the relationship between oxidizing agents (free radicals) and antioxidant system, is able to influence the correct performance of the oestrous cycle. The aim of the experimentation was to define a first range of physiological values of reactive oxygen species (ROS) and the biological antioxidant potential (BAP), found during the phases of the buffalo estrous cycle. In this study, blood samples were taken from 30 buffaloes in various phases of the estrous cycle (oestrus, dioestrus, anoestrus), on whose serum by photometer, determinations of BAP and ROS have been carried out. The highest ROS values were detected during oestrus and this is due to the primary role they play in determining ovulation. The highest levels of BAP have been ManuscriptClick here to access/download;Manuscript;manuscript buffalo.doc Click here to view linked References 2 found in dioestrus, when they perform protective action against oxidative damage in the ovaries and uterus.

show abstract

Concentrations of free radicals and beta-endorphins in repeat breeder cows

Cited by 28 publications

References 25 publications

Evaluation of blood and milk oxidative status during early postpartum of dairy cows

Evaluation of blood and milk oxidative status during early postpartum of dairy cows

Clinical Use of Progesterone and Its Relation to Oxidative Stress in Ruminants

Oxidative state in the estrus cycle of the buffaloes: a preliminary study

Contact Info

Product

Resources

About