Concentrations of leptin and C-reactive protein in serum and follicular fluid during assisted reproductive cycles

Wunder, Dorothea; Kretschmer, R; Bersinger, Nick A.

doi:10.1093/humrep/deh767

Cited by 49 publications

(43 citation statements)

References 29 publications

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“…In the present study, we have failed to observe any statistically significant correlation between day 3 hs-CRP and IVF cycle outcomes or clinical pregnancy. Our findings concur with other studies [19,20] which found no correlation between circulating levels of hs-CRP prior to ovarian stimulation with gonadotrophins and IVF outcome. In contrast, Levin and colleagues [17], who measured hs-CRP at different time points, noted that hs-CRP concentrations on day 3 correlated with IVF treatment failure.…”

Section: Discussionsupporting

confidence: 93%

“…In fact, adipose tissue is a potent source of inflammatory interleukins and other circulating cytokines, the secretion of which increase with adiposity [25][26][27]. In agreement with previous studies [20,28], we have found a significant correlation between basal hs-CRP and BMI. Furthermore, although the mean BMI of women who conceived was higher than those who had a unsuccessful cycle (26.3±3.15 and 25.0±2.68 kg/m 2 ), this failed to reach statistical significance.…”

Section: Discussionsupporting

confidence: 92%

“…The available studies present considerable differences in design, subjects and methods, reaching contradictory results [17][18][19][20]. Gonadotrophin hyperstimulation, oocyte retrieval and blastocyst-endometrium interaction (i.e., early stages of implantation) are thought to induce a temporary inflammatory state as evidenced by a rise in CRP levels and inflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

“…Levin and colleagues [17] reported that higher CRP levels during IVF stimulation were associated with failure of conception. Conversely, other authors [19,20] found that CRP measurements were not a predictive marker of IVF success.…”

Section: Introductionmentioning

confidence: 89%

“…As yet, a handful of studies have investigated CRP levels during assisted conception, making it difficult to know the expected normal levels in different subgroups of patients [17][18][19][20]. Levin and colleagues [17] reported that higher CRP levels during IVF stimulation were associated with failure of conception.…”

Section: Introductionmentioning

confidence: 99%

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Low grade inflammation, as evidenced by basal high sensitivity CRP, is not correlated to outcome measures in IVF

Robinson

Pemberton

Laing

et al. 2008

J Assist Reprod Genet

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Purpose To assess the relationship between low-grade inflammation, measured as basal high sensitivity (hs)-CRP, and IVF outcome. Methods We recruited a total of 220 women undergoing infertility work up prior to IVF. Patients were selected for a BMI<30 kg/m 2 with an upper age limit of 40 years. Serum hs-CRP levels were measured on day 3 of a spontaneous menstrual cycle preceding ovarian stimulation. A sensitive two-site ELISA was used for analysis. Dose of gonadotrophins required, follicles days 8 and 10, number of oocytes collected, number of oocytes fertilised and pregnancy outcome were recorded. Results Median hs-CRP was 1.08 mg/L (0.43-3.00 mg/L). The hs-CRP was significantly related to BMI (r=0.386, P<.001) but not to age and smoking habit. There were no significant relationships between basal hs-CRP and any of the measured IVF outcomes. Conclusions These findings demonstrate that serum hs-CRP concentration is not a predictive marker of cycle or pregnancy outcome in women undergoing IVF treatment.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Low grade inflammation, as evidenced by basal high sensitivity CRP, is not correlated to outcome measures in IVF

Robinson

Pemberton

Laing

et al. 2008

J Assist Reprod Genet

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Mass spectrometry‐based proteomics in reproductive medicine

Kοlialexi¹,

Mavrou²,

Spyrou

et al. 2008

Mass Spectrometry Reviews

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The emergence of powerful mass spectrometry-based proteomic techniques has added a new dimension to the field of biomedical research. Application of these high throughput methodologies in pregnancy-related pathology has contributed to the comprehension of the underlying pathophysiologies and the successful identification of relevant protein biomarkers that can potentially change early diagnosis and treatment of several medical conditions related to human pregnancy. Most of the existing research on human reproduction and gestation has focused on follicular fluid, cervical/vaginal fluid, and amniotic fluid. Although proteome technologies in reproductive medicine research are not as yet widely applied, characterization of the proteome of reproductive fluids can be expected to significantly improve maternal healthcare. This article aims to summarize the applications of mass spectrometry based technology on the most important and specific biological fluids related to reproduction and gestation.

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Cytokines in ovarian folliculogenesis, oocyte maturation and luteinisation

Field

Dasgupta

Cummings

et al. 2013

Molecular Reproduction Devel

166

110

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SUMMARYCytokines are key regulators of ovarian physiology, particularly in relation to folliculogenesis and ovulation, where they contribute to creating an environment supporting follicle selection and growth. Their manifold functions include regulating cellular proliferation/differentiation, follicular survival/atresia, and oocyte maturation. Several cytokines, such as TGF-b-superfamily members, are involved at all stages of folliculogenesis while the production of others is stage-dependent. This review draws upon evidence from both human and animal models to highlight the species-specific roles at each milestone of follicular development. Given these pivotal roles and their ease of detection in follicular fluid, cytokines have been considered as attractive biomarkers of oocyte maturational status and of successful assisted reproductive outcome. Despite this, our understanding of cytokines and their interactions remains incomplete, and is still frequently limited to overly simplistic descriptions of their interrelationships. Given our increased appreciation of cytokine activity in complex and highly regulated networks, we put forward the case for using Bayesian modelling approaches to describe their hierarchical relationships in order to predict causal physiological interactions in vivo.Mol. Reprod. Dev. 81: 284À314,

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Concentrations of leptin and C-reactive protein in serum and follicular fluid during assisted reproductive cycles

Abstract: Leptin and C-reactive protein levels change significantly during assisted reproductive treatment. In contrast to estradiol they are, however, not a marker of success.

Cited by 49 publications

References 29 publications

Low grade inflammation, as evidenced by basal high sensitivity CRP, is not correlated to outcome measures in IVF

Low grade inflammation, as evidenced by basal high sensitivity CRP, is not correlated to outcome measures in IVF

Mass spectrometry‐based proteomics in reproductive medicine

Cytokines in ovarian folliculogenesis, oocyte maturation and luteinisation

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