Conceptual Model to Illustrate the Symptom Experience and Humanistic Burden Associated With Atopic Dermatitis in Adults and Adolescents

Grant, Laura; Larsen, Lotte Seiding; Trennery, Claire; Silverberg, Jonathan I.; Abramovits, William; Simpson, Eric L.; Stalder, J.F.; Paty, Jean A.; Hahn-Pedersen, Julie; Kragh, Nana; Bang, Bo; Arbuckle, Rob

doi:10.1097/der.0000000000000486

Cited by 26 publications

(18 citation statements)

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“…I try not to use too much, plain and simple, and hope it is…that I'm like doing what you're supposed to (7) Difficult to get help There was a perception among the young adults that it was difficult to get help from healthcare, both making an appointment and getting the 'right' treatment. The respondents did not state any experiences of education in self-management by healthcare.…”

Section: 'It Stings Of Course Every Time I Apply the Cream' (15)mentioning

confidence: 99%

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Young adults’ perceptions of living with atopic dermatitis in relation to the concept of self-management: a qualitative study

et al. 2021

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ObjectivesLearning to take control of one’s health is an important part of the transition from adolescence to adulthood. This study aimed to explore young adults’ perceptions of living with atopic dermatitis (AD) in relation to the concept of self-management.DesignA qualitative study with an inductive approach was performed through semistructured interviews (n=15). The interviews were recorded, transcribed verbatim and analysed with systematic text condensation.ParticipantsYoung adults (mean age 23,4 years) with persistent AD in a longitudinal population-based birth cohort. To capture experience of living with persistent AD (preschool/school-age onset) of different severity (mild to severe/very severe), a purposive selection was performed. In total, 15 young adults were included. Persistent AD (preschool/school-age onset) was defined as dry skin in combination with itchy rash of typical localisation in the 12 months preceding the 16-year and the 24-year follow-ups. Severity was self-assessed using the Patient Oriented Eczema Measure.ResultsDespite having experience of AD since childhood, the respondents expressed uncertainty about treatment and how it affected their bodies. Their uncertainties and feelings affected how they used topical corticosteroids. The respondents emphasised that they perceived availability of healthcare and knowledge about treatment of AD among healthcare providers to be limited. The participants did not state any experiences of support to self-management from healthcare, which affect young adults’ possibilities to take full control of their AD care.ConclusionsYoung adults with preschool/school-age onset of AD are unsure how to treat and manage the disease. One explanation may be insufficient transition process.

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Section: 'It Stings Of Course Every Time I Apply the Cream' (15)mentioning

confidence: 99%

“…It's, like, something you have, you have to learn to live with it, maybe (7) While they had accepted their disease, they tried to avoid revealing their AD, in so far as possible, when it was in visible places on their bodies.…”

Section: Acceptancementioning

confidence: 99%

Young adults’ perceptions of living with atopic dermatitis in relation to the concept of self-management: a qualitative study

et al. 2021

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“…Skin pain (which is described by patients using terms such as discomfort or soreness) is an important symptom in AD which until recently was not widely recognized by dermatologists or treatment guidelines [7], despite being one of the most frequently reported symptoms of AD after itch [8]. Skin pain can be linked to the severity of AD and itching [9], but it may also be experienced independent of itch and the itch-scratch cycle [10,11].…”

Section: Introductionmentioning

confidence: 99%

Baricitinib Rapidly Improves Skin Pain Resulting in Improved Quality of Life for Patients with Atopic Dermatitis: Analyses from BREEZE-AD1, 2, and 7

Thyssen

Buhl

Fernández‐Peñas

et al. 2021

Dermatol Ther (Heidelb)

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Introduction: Skin pain (described as discomfort or soreness) is increasingly recognized as a symptom of atopic dermatitis which impacts patient quality of life. This analysis examined the effect of baricitinib on skin pain in atopic dermatitis in three phase 3 studies (BREEZE-AD1, -AD2, and -AD7). Methods: Patients were randomly assigned 2:1:1:1 to receive once-daily placebo, baricitinib 1 mg, 2 mg, or 4 mg in BREEZE-AD1 (N = 624) and -AD2 (N = 615) and 1:1:1 to receive oncedaily placebo, baricitinib 2 mg, or 4 mg, with topical corticosteroids, in BREEZE-AD7 (N = 329) for 16 weeks. Patients recorded their skin pain severity using the Skin Pain Numerical Rating Scale (NRS) via an electronic daily diary. Data were analyzed by study as least squares mean change from baseline in daily scores for the randomly assigned patients using mixed model repeated measures analysis. Analysis of

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“…A patient's quality of life becomes severely affected due to chronic pruritus [4][5][6]. AD patients often suffer from insomnia, anxiety, depression, and other emotional disorders [4,7,8]. Several studies have been focused on understanding the symptoms and mechanisms of AD; however, these have not yet been fully elucidated, which has limited the development of novel therapeutic strategies.…”

Section: Introductionmentioning

confidence: 99%

Antipruritic Effect of Ethyl Acetate Extract from Fructus cnidii in Mice with 2,4‐Dinitrofluorobenzene‐Induced Atopic Dermatitis

Chen

Zhu

Zhang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Atopic dermatitis (AD) is a common inflammatory skin disease characterized by intense pruritus and skin lesions. The exact cause of AD is not yet known and the available therapeutic strategies for AD are limited. Fructus cnidii is commonly used in traditional Chinese medicine as an herb for treating chronic itch. However, the mechanism underlying the antipruritic effects of Fructus cnidii is not well understood. In the present study, we investigated the antipruritic effect of locally administered ethyl acetate extract from Fructus cnidii (EAEFC) to 2,4-dinitrofluorobenzene- (DNFB-) induced AD in a mouse model. The scratching behavior, skin thickness, dermatitis score, weight, blood immunoglobulin E (IgE) level, and itch-related cytokine levels were subsequently monitored and evaluated. Results showed that EAEFC treatment attenuated the DNFB-induced AD-like symptoms by alleviating the skin lesions and decreasing the dermatitis score. Hematoxylin and eosin (H&E) and toluidine blue (TB) staining analyses demonstrated that EAEFC mitigated the DNFB-induced increase in skin thickness and prevented the infiltration of mast cells. Behavioral tests showed that EAEFC decreased the DNFB-induced acute and chronic scratching behaviors. Furthermore, EAEFC reduced the levels of itch-related cytokines, such as thymic stromal lymphopoietin (TSLP), interleukin- (IL-) 17, IL-33, and IL-31, and the DNFB-induced boost in serum IgE. Collectively, these results suggest that EAEFC is a potential therapeutic candidate for the treatment of chronic itch in AD.

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Conceptual Model to Illustrate the Symptom Experience and Humanistic Burden Associated With Atopic Dermatitis in Adults and Adolescents

Abstract: Supplemental digital content is available in the text.

Cited by 26 publications

References 24 publications

Young adults’ perceptions of living with atopic dermatitis in relation to the concept of self-management: a qualitative study

Young adults’ perceptions of living with atopic dermatitis in relation to the concept of self-management: a qualitative study

Baricitinib Rapidly Improves Skin Pain Resulting in Improved Quality of Life for Patients with Atopic Dermatitis: Analyses from BREEZE-AD1, 2, and 7

Antipruritic Effect of Ethyl Acetate Extract from Fructus cnidii in Mice with 2,4‐Dinitrofluorobenzene‐Induced Atopic Dermatitis

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