Concise review: Medicinal plants are effective against leishmaniasis

Bahmani, Mahmoud; Abbasi, Naser; Hosseini, Masih; Rafieian-Kopaei, Mahmoud

doi:10.15419/bmrat.v4i11.383

Cited by 5 publications

(3 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, during the last decade, natural compounds and their derivatives have been identified as a source of therapeutic agents. It was found that medicinal plants were effective against leishmaniasis [77]. The antileishmanial activities, on Leishmania infantum promastigotes, of 12 semisynthetic terpenoid derivatives obtained by several chemical modifications of E. resinifera major compounds (Demnat, Morocco) were studied by Mazoir et al (2011) [20].…”

Section: Antileishmanial Activitymentioning

confidence: 99%

Ethnomedicinal Use, Phytochemistry, Pharmacology, and Toxicology of Euphorbia resinifera O. Berg. (B): A Review

Hmidouche

Bouftini

Chafik

et al. 2023

JZBG

View full text Add to dashboard Cite

Euphorbia resinifera (Zaggûm or Tikiut) is an endemic species of Morocco that grows in the Middle Atlas Mountain range. It is used in folk medicine to treat several diseases, especially various types of cancer. Aim of the review: In this review, we critically highlighted and discussed previous reports on E. resinifera, concerning its botanical description, taxonomy, geographical distribution, and medicinal use. In addition, bioactive compounds, toxicology, and pharmacological effects were reported. Materials and methods: We searched various scientific databases, such as Scopus, PubMed, Web of Science, SpringerLink, SciFinder, Wiley Online, and Google Scholar, to collect data on E. resinifera. Studies involving E. resinifera or its bioactive compounds with regards to antitumor, anti-inflammatory, antileishmanial, antiprotease, immunomodulatory, irritant, and lysosomal activities are discussed here. Results: E. resinifera has been widely used in folk medicine practice in Morocco to treat several diseases such as diabetes, cancer, and inflammatory skin conditions, as well as to heal wounds. In phytochemistry studies, biochemical compounds have been identified from E. resinifera belonging specially to terpenoids. Indeed, in vitro and in vivo pharmacological investigations showed that extracts and compounds from the latex of E. resinifera exhibited a wide spectrum of biological properties, particularly antioxidant, antimicrobial, antitumor, anti-inflammatory, antileishmanial, and immunomodulatory and neuroprotective activities. Conclusion: The use of E. resinifera in conventional medicine is supported by processes founded on biological evidence. However, in-depth research is necessary to prove the safety and efficacy of E. resinifera latex extracts and their compounds and to clarify their pharmacological mechanisms. In addition, pharmacokinetic and pharmacodynamics studies are required for extracts and bioactive compounds.

show abstract

Section: Antileishmanial Activitymentioning

confidence: 99%

Ethnomedicinal Use, Phytochemistry, Pharmacology, and Toxicology of Euphorbia resinifera O. Berg. (B): A Review

Hmidouche

Bouftini

Chafik

et al. 2023

JZBG

View full text Add to dashboard Cite

show abstract

“…102 Emetine and cephaline has potential for production of potent drugs against Leishmaniasis. 103 Emetine an anti-protozoal agent, potently inhibits both ZIKV and EBOV entry in vitro and potent activity in vivo. Cephaeline, a desmethyl analog of emetine, also displays a similar efficacy against ZIKV as well as EBOV infections.…”

Section: Biological Activities Of Emetine and Cephalinementioning

confidence: 99%

A Paradoxically Significant Medicinal Plant Carapichea ipecacuanha: A Review

Mondal¹,

Moktan²

2020

IJPER

View full text Add to dashboard Cite

Background: Carapichea ipecacuanha (Brot.) L. Andersson is the botanical source of Ipecac drug and contains major alkaloids emetine, cephaline that are pharmaceutically used against bronchitis associated with cough in children, severe diarrhea (amoebic dysentery) and also cancer. Ipecac serves as an expectorant to thin mucous and easy coughing. Low doses are used to enhance appetite and it is administered orally to cause vomiting after suspected poisoning. Materials and Methods: The review highlights the taxonomy, nomenclature, distribution, medicinal uses and major pharmacological activities including side effects of Ipecac drug reported in recent years consulting various published papers dealing with Ipecac. Results and Conclusion: The species is rarely distributed due to disturbances in their habitats in natural growing condition. Further studies are required to scientifically evaluate the traditional uses of this plant through extraction and identification of their active ingredients and the mechanisms and mode of action that would serve as a source of collective information on this plant.

show abstract

“…In recent years, the in vitro and in vivo anti-leishmanial activities of several plants, e.g. Pistachio species, Ziziphus spina-christi, Myrtus communis, Trichodesma africana and Pergularia tomentosa have been reported, which show that the use of these plants can lead to wound healing in animal models (Bahmani et al, 2015;Bahmani et al, 2017); however, final acceptance of the use of medicinal herbs for CL treatment is still held up by variable results of investigations that are seldom sufficiently powered.…”

Section: Introductionmentioning

confidence: 99%

Stachys lavandulifolia Vahl. exhibits promising in vitro and in vivo antileishmanial activity against Leishmania major infection

A.D.¹

2022

Trop Biomed

View full text Add to dashboard Cite

This study aimed to consider the in vitro and in vivo effects of the Stachys lavandulifolia methanolic extract (SLME) (2.5, 5, 10, 25, 50, 100 µg/mL) against Leishmania major infection. The in vitro antileishmanial effects of SLME was studies on promastigote and amastigote forms of L. major. The effect of SLME on the nitric oxide (NO) and apoptosis, secretion of Th1/2 cytokines, and infectivity rate in macrophages cells were also studies. The cytotoxicity of SLME on human (THP-1) and murine (J774-A1 cell) macrophage cells was investigated through the measuring the 50% cytotoxic concentrations (CC 50 ). Moreover, the in vivo effects of SLME for healing the cutaneous leishmaniasis (CL) lesions in infected BALB/c mice studied by assessing the lesions size and the parasite load during four weeks of treatment. The calculated 50% inhibitory concentration (IC 50 ) values for SLME and meglumine antimoniate (MA) against the promastigote stage were 23.4 and 71.1 µg/mL, respectively. For amastigote stage, the IC 50 values for SLME and MA were 39.3 µg/mL and 44.3 µg/mL, respectively. Followed by 28 days' topically therapy with SLME at doses of 50 and 100 mg/kg/day, the CL lesions size as well as parasite load were significantly (p<0.001) reduced; such that the recovery percentage of the infected mice was 80% and 97% after treatment with SLME at the dose of 50 and 100 mg/kg, respectively. SLME also markedly induced the NO production and apoptosis; whereas decreased infection rate in macrophage cells. After incubation of infected macrophages with SLME, the level interferon gamma was meaningfully (p<0.001) elevated as a dose-dependent response; in contrast, release of interleukin 10 (IL-10) and IL-4 markedly (p<0.001) decreased. The CC 50 value for SLME against THP-1 and J774-A1 cell was 996.4 µg/mL and 741.3 µg/mL, respectively. The calculated selectivity index of >10 for SLME and MA confirmed their specificity to amastigotes and the low toxicity for macrophages. Our results showed the potent effects of SLME in eliminating and controlling Leishmania parasites in both in vitro and in vivo assays. Based on the current experimental study, SLME can be suggested as an alternative medicine for the isolation and production of a new agent for treating CL caused by L. major. Although, we found some cellular mechanisms of SLME against Leishmania parasites, but, additional surveys are necessary to specify the accurate mechanisms of action, toxicity, and its efficacy mainly in human subjects.

show abstract

Concise review: Medicinal plants are effective against leishmaniasis

Cited by 5 publications

References 27 publications

Ethnomedicinal Use, Phytochemistry, Pharmacology, and Toxicology of Euphorbia resinifera O. Berg. (B): A Review

Ethnomedicinal Use, Phytochemistry, Pharmacology, and Toxicology of Euphorbia resinifera O. Berg. (B): A Review

A Paradoxically Significant Medicinal Plant Carapichea ipecacuanha: A Review

Stachys lavandulifolia Vahl. exhibits promising in vitro and in vivo antileishmanial activity against Leishmania major infection

Contact Info

Product

Resources

About