Concise Review: Multipotent Mesenchymal Stromal Cells in Blood

He, Qiang; Wan, Chao; Li, Gang

doi:10.1634/stemcells.2006-0335

Cited by 258 publications

(183 citation statements)

References 139 publications

(219 reference statements)

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“…The concept of MSCs being present in the peripheral blood under normal physiological conditions is divisive; some studies have identified low frequencies of MSCs within the circulation, whereas other studies have been unable to detect their presence (He et al, 2007). However, in response to injury, cytokines, chemokines and neuroendocrine modulators are released, initiating processes thought to mobilise and recruit regenerative cells.…”

Section: Pharmacological Interventions To Enhance Tissue Repairmentioning

confidence: 99%

Pericytes, mesenchymal stem cells and their contributions to tissue repair

Wong

Rowley

Redpath

et al. 2015

Pharmacology & Therapeutics

152

110

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Regenerative medicine using mesenchymal stem cells for the purposes of tissue repair has garnered considerable public attention due to the potential of returning tissues and organs to a normal, healthy state after injury or damage has occurred. To achieve this, progenitor cells such as pericytes and bone marrow-derived mesenchymal stem cells can be delivered exogenously, mobilised and recruited from within the body or transplanted in the form organs and tissues grown in the laboratory from stem cells. In this review, we summarise the recent evidence supporting the use of endogenously mobilised stem cell populations to enhance tissue repair along with the use of mesenchymal stem cells and pericytes in the development of engineered tissues. Finally, we conclude with an overview of currently available therapeutic options to manipulate endogenous stem cells to promote tissue repair.

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Section: Pharmacological Interventions To Enhance Tissue Repairmentioning

confidence: 99%

Pericytes, mesenchymal stem cells and their contributions to tissue repair

Wong

Rowley

Redpath

et al. 2015

Pharmacology & Therapeutics

152

110

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“…With respect to bone repair, this new concept is plausible because there is an abundant reserve of endogenous adult stem cells in bone marrow [21]. These endogenous progenitor cells can be mobilized to the PB [1,11,12,15,17,22,36,48,52].…”

Section: Introductionmentioning

confidence: 99%

Adult Stem Cell Mobilization Enhances Intramembranous Bone Regeneration: A Pilot Study

McNulty

Virdi

Christopherson

et al. 2012

Clinical Orthopaedics &Amp; Related Research

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Background Stem cell mobilization, which is defined as the forced egress of stem cells from the bone marrow to the peripheral blood (PB) using chemokine receptor agonists, is an emerging concept for enhancing tissue regeneration. However, the effect of stem cell mobilization by a single injection of the C-X-C chemokine receptor type 4 (CXCR4) antagonist AMD3100 on intramembranous bone regeneration is unclear.

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“…In theory, they could locally migrate to the sites of inflammation from the surrounding solid tissues (such as WAT), arrive through the systemic circulation, or both [42] . MSC are virtually absent in the peripheral circulation of healthy individuals although hypoxia and inflammation signals are believed to result in MSC mobilization and migration from their niche [94,117,118] . The possibility of spontaneous MSC mobilization in disease has been widely speculated upon, and could underlie their recruitment by tumors although this remains to be tested.…”

Section: Resultsmentioning

confidence: 99%

Adipose Tissue-Derived Progenitor Cells and Cancer

Tseng¹,

Kolonin²

2013

Angiogenesis in Adipose Tissue

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Recruitment of stem cells and partially differentiated progenitor cells is a process which accompanies and facilitates the progression of cancer. One of the factors complicating the clinical course of cancer is obesity, a progressively widespread medical condition resulting from overgrowth of white adipose tissue (WAT), commonly known as white fat. The mechanisms by which obesity influences cancer risk and progression are not completely understood. Cells of WAT secret soluble molecules (adipokines) that could stimulate tumor growth, although there is no consensus on which cell populations and which adipokines are important. Recent reports suggest that WAT-derived mesenchymal stem (stromal) cells, termed adipose stem cells (ASC), may represent a cell population linking obesity and cancer.Studies in animal models demonstrate that adipokines secreted by ASC can promote tumor growth by assisting in formation of new blood vessels, a process necessary for expansion of tumor mass. Importantly, migration of ASC from WAT to tumors has been demonstrated, indicating that the tumor microenvironment in cancer may be modulated by ASC-derived trophic factors in a paracrine rather than in an endocrine manner. Here, we review possible positive and adverse implications of progenitor cell recruitment into the diseased sites with a particular emphasis on the role in cancer progression of progenitors that are expanded in obesity.

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Concise Review: Multipotent Mesenchymal Stromal Cells in Blood

Cited by 258 publications

References 139 publications

Pericytes, mesenchymal stem cells and their contributions to tissue repair

Pericytes, mesenchymal stem cells and their contributions to tissue repair

Adult Stem Cell Mobilization Enhances Intramembranous Bone Regeneration: A Pilot Study

Adipose Tissue-Derived Progenitor Cells and Cancer

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