Concise route to stereoselective chlorobenzene-based spiropyrrolidine oxindoles for pursuit as antitubercular agents

Activity against Mycobacterium tuberculosis of a new class of spirooxindolopyrrolidine embedded chromanone hybrid heterocycles

“…al. 18 reported the synthesis, characterization, molecular docking simulation and antitubercular activity of new class of spiropyrrolidine oxindoles, these compounds showed signicant activity against tested Mycobacterium tuberculosis H37R. In addition, to the biological precedents of the spiro compounds described above, most of the spiropyrrolidines reported in the literature demonstrated significant biological activity, including anti-TB activity, 19,20 some of these spiro compounds were even more potent than reference standard.…”