Concizumab prophylaxis in persons with hemophilia A or B with inhibitors: patient-reported outcome results from the phase 3 explorer7 study

Tran, Huyen; von Mackensen, Sylvia; Abraham, Aby; Castaman, Giancarlo; Hampton, Kingsley; Knoebl, Paul; Linari, Silvia; Odgaard-Jensen, Jan; Neergaard, Jesper Skov; Stasyshyn, Oleksandra; Thaung Zaw, Jay Jay; Zulfikar, Bulent; Shapiro, Amy

doi:10.1016/j.rpth.2024.102476

Research and Practice in Thrombosis and Haemostasis

2024

DOI: 10.1016/j.rpth.2024.102476

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Concizumab prophylaxis in persons with hemophilia A or B with inhibitors: patient-reported outcome results from the phase 3 explorer7 study

Huyen Tran,

Sylvia von Mackensen,

Aby Abraham

et al.

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Non-factor Therapies for Hemophilia: Achievements and Perspectives

Jiménez-Yuste

2024

Semin Thromb Hemost

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Non-factor replacement therapies (NFTs) have been developed to address the limitations of conventional replacement therapies, aiming to improve hemostasis and provide enhanced protection against bleeding episodes and long-term joint damage for patients both with and without inhibitors. Factor VIII (FVIII)-mimetic agents, such as emicizumab, have transformed the management of hemophilia A with inhibitors, offering a lower treatment burden and an effective alternative for those without inhibitors as well. Rebalancing agents, including anti-tissular factor pathway inhibitor agents (concizumab and marstacimab) and serpin inhibitors like fitusiran, have shown promising efficacy for patients with hemophilia B with inhibitors and other hemophilia subtypes. Administered subcutaneously, NFTs generate stable thrombin levels and feature a long half-life, which can shift severe hemophilia toward a milder phenotype. These therapies are effective regardless of inhibitor status and hold potential for application in other bleeding disorders. Evaluating the potential thrombotic risk after implementing mitigation measures, along with the development of anti-drug antibodies (ADAs), remain critical areas for further analysis. NFTs pose additional challenges due to their complex mechanism of action and the absence of a standardized laboratory assessment method. Unresolved issues include optimal management strategies for major surgeries and tailored approaches for safe use in older populations. This review highlights the progress and future potential of NFTs in treating persons with hemophilia.

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Non-factor Therapies for Hemophilia: Achievements and Perspectives

Jiménez-Yuste

2024

Semin Thromb Hemost

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Concizumab prophylaxis in persons with hemophilia A or B with inhibitors: patient-reported outcome results from the phase 3 explorer7 study

Cited by 1 publication

References 35 publications

Non-factor Therapies for Hemophilia: Achievements and Perspectives

Non-factor Therapies for Hemophilia: Achievements and Perspectives

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