Concomitant and protective immunity in mice exposed to repeated infections with Echinostoma malayanum

Srisawangwong, Tuanchai; Sithithaworn, Paiboon; Sukkasaem, Pasana; Jintakanon, Darunee; Tesana, Smarn; Sithithaworn, Jiraporn; Andrews, Ross H.; Fried, Bernard

doi:10.1016/j.exppara.2011.01.010

Cited by 7 publications

(2 citation statements)

References 30 publications

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“…Exposure-dependent immunity of this type has been invoked to explain age-related declines for macroparasites of humans, domestic stock, and laboratory animals (Woolhouse, 1998). The results of experimental studies indicate that established macroparasites often promote the production of anti-parasite antibodies, leading to protection against subsequent exposures (Srisawangwong et al., 2011). In natural systems, a delayed antibody-based response to nematodes has been documented in wood mice, Apodemus sulvaticus (Quinnell, 1992), and Soay sheep, Ovis aries (Gulland and Fox, 1992).…”

Section: Discussionmentioning

confidence: 99%

Fluke abundance versus host age for an invasive trematode (Dicrocoelium dendriticum) of sympatric elk and beef cattle in southeastern Alberta, Canada

Beck

Goater

Colwell

et al. 2014

International Journal for Parasitology: Parasites and Wildlife

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Section: Discussionmentioning

confidence: 99%

Fluke abundance versus host age for an invasive trematode (Dicrocoelium dendriticum) of sympatric elk and beef cattle in southeastern Alberta, Canada

Beck

Goater

Colwell

et al. 2014

International Journal for Parasitology: Parasites and Wildlife

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“…E. malayanum infection in an animal model was reported in Swiss albino mice [ 11 , 12 ]. The infectivity rate was 100%, which agreed to the findings in our present study.…”

Section: Discussionmentioning

confidence: 99%

Animal Models for <i>Echinostoma malayanum</i> Infection: Worm Recovery and Some Pathology

et al. 2016

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Echinostomes are intestinal trematodes that infect a wide range of vertebrate hosts, including humans, in their adult stage and also parasitize numerous invertebrate and cold-blooded vertebrate hosts in their larval stages. The purpose of this study was to compare Echinostoma malayanum parasite growth, including worm recovery, body size of adult worms, eggs per worm, eggs per gram of feces, and pathological changes in the small intestine of experimental animals. In this study, 6-8-week-old male hamsters, rats, mice, and gerbils were infected with echinostome metacercariae and then sacrificed at day 60 post-infection. The small intestine and feces of each infected animal were collected and then processed for analysis. The results showed that worm recovery, eggs per worm, and eggs per gram of feces from all infected hamsters were higher compared with infected rats and mice. However, in infected gerbils, no parasites were observed in the small intestine, and there were no parasite eggs in the feces. The volume of eggs per gram of feces and eggs per worm were related to parasite size. The results of histopathological changes in the small intestine of infected groups showed abnormal villi and goblet cells, as evidenced by short villi and an increase in the number and size of goblet cells compared with the normal control group.

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Echinostomes

Chai

2019

Human Intestinal Flukes

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Concomitant and protective immunity in mice exposed to repeated infections with Echinostoma malayanum

Cited by 7 publications

References 30 publications

Fluke abundance versus host age for an invasive trematode (Dicrocoelium dendriticum) of sympatric elk and beef cattle in southeastern Alberta, Canada

Fluke abundance versus host age for an invasive trematode (Dicrocoelium dendriticum) of sympatric elk and beef cattle in southeastern Alberta, Canada

Animal Models for <i>Echinostoma malayanum</i> Infection: Worm Recovery and Some Pathology

Echinostomes

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