Concomitant factor I and IgA deficiencies in a Brazilian child

Amadei, N.; Paula, P. Ferreira de; Florido, M.P.C.; W, Bastos; Nudelman, Victor; Isaac, Lourdes

doi:10.1016/s0161-5890(98)90644-7

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2000

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“…The association of factor I deficiency and abnormality in factor H electrophoretic migration has been observed previously (11,21) and may be explained by binding of factor H to C3b. Another Brazilian family has been studied in our laboratory in which two sisters present this same deficiency (22). The oldest daughter developed systemic lupus erythematosus and the youngest daughter, although she had not previously developed autoimmune or recurrent infections, died of sepsis at the age of 3 years (22).…”

Section: Discussionmentioning

confidence: 99%

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Deficiency of Human Complement Factor I Associated with Lowered Factor H

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Florido

Paula

et al. 2000

Clinical Immunology

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Section: Discussionmentioning

confidence: 99%

“…Another Brazilian family has been studied in our laboratory in which two sisters present this same deficiency (22). The oldest daughter developed systemic lupus erythematosus and the youngest daughter, although she had not previously developed autoimmune or recurrent infections, died of sepsis at the age of 3 years (22).…”

Section: Discussionmentioning

confidence: 99%