Concomitant herpes simplex virus and cytomegalovirus endotheliitis in immunocompetent patient

Abstract

A case of an immunocompetent 51-year-old healthy man with chronic recurrent disciform corneal oedema and hypertensive anterior uveitis in the right eye for 2 years was unresponsive to topical corticosteroid and systemic acyclovir. Diagnostic anterior chamber tapping was performed and viral DNA PCR was positive for both cytomegalovirus and herpes simplex virus. The patient was treated with both oral valganciclovir for 3 months and long-term oral acyclovir. His condition improved significantly after the treatment; intraocular pressure and anterior chamber inflammation were controlled and the remaining keratic precipitates in the cornea started to clear up.

Combined Cytomegalovirus and Herpes Simplex Virus-related Neuroretinitis in an Immunocompetent Patient

“…HSV-related optic neuropathy can be caused by several mechanisms, including intraneural vasculitis, compressive ischemia of the optic nerve, and inflammation and necrosis due to direct herpes virus infection [3]. Concomitant ocular infection with CMV and HSV has been reported as endotheliitis in an immunocompetent patient [4]. However, there has been no case report on concomitant infection of CMV and HSV neuroretinitis in an immunocompetent patient.…”

Herpes simplex keratitis-induced endophthalmitis in a patient with AIDS with disseminated tuberculosis

“…Oral and topical corticosteroids were given for intraocular inflammation. Topical brimonidine and timolol maleate were given to reduce IOP 27 28…”

Effectiveness of Seydana oil in combination treatment of herpetic endothelial keratitis

“…Согласно опубликованным в 2015 г. первым глобальным оценкам ВОЗ о распространенности вируса простого герпеса типа 1 (ВПГ-1), во всем мире этим вирусом инфицированы более 3,7 млрд человек в возрасте до 50 лет, или 67 % населения [1]. Увеличение частоты заболеваемости офтальмогерпесом связывают с широким использованием стероидных препаратов, антибиотиков, антиглаукомных капель, с увеличением числа эпидемий гриппа, которые провоцируют вспышки вирусных поражений глаз [4][5][6]. В последние годы значительно расширился спектр доказанных факторов риска рецидива офтальмогерпеса, связанных с внедрением новых технологий: рефракционной хирургии, лазерной иридотомии, фемтосекундной лазерной кератотомии, кератопластики, кератопротезирования, катарактальной хирургии [7][8][9].…”