Concurrent Adrenocortical Carcinoma and Hepatocellular Carcinoma with Hemosiderosis in a Sugar Glider (Petaurus breviceps)

Lindemann, D.; Carpenter, James W.; DeBey, Brad M.; Ryseff, Julia K.

doi:10.1053/j.jepm.2016.03.013

Cited by 13 publications

(6 citation statements)

References 8 publications

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“…Isolated reports in sugar gliders ( Petaurus breviceps ) show one case of hemangiosarcoma (Rivas, Pye & Papendick, ), one case of concurrent adrenocortical carcinoma and hepatocellular carcinoma (Lindemann et al, ), and two cases of metastatic mammary carcinoma (Keller et al, ; Churgin et al, ).…”

Section: Cancer Across the Tree Of Lifementioning

confidence: 99%

From humans to hydra: patterns of cancer across the tree of life

et al. 2018

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Cancer is a disease of multicellularity; it originates when cells become dysregulated due to mutations and grow out of control, invading other tissues and provoking discomfort, disability, and eventually death. Human life expectancy has greatly increased in the last two centuries, and consequently so has the incidence of cancer. However, how cancer patterns in humans compare to those of other species remains largely unknown. In this review, we search for clues about cancer and its evolutionary underpinnings across the tree of life. We discuss data from a wide range of species, drawing comparisons with humans when adequate, and interpret our findings from an evolutionary perspective. We conclude that certain cancers are uniquely common in humans, such as lung, prostate, and testicular cancer; while others are common across many species. Lymphomas appear in almost every animal analysed, including in young animals, which may be related to pathogens imposing selection on the immune system. Cancers unique to humans may be due to our modern environment or may be evolutionary accidents: random events in the evolution of our species. Finally, we find that cancer‐resistant animals such as whales and mole‐rats have evolved cellular mechanisms that help them avoid neoplasia, and we argue that there are multiple natural routes to cancer resistance.

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Section: Cancer Across the Tree Of Lifementioning

confidence: 99%

From humans to hydra: patterns of cancer across the tree of life

et al. 2018

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“…In humans, dogs, and cats, cholangiocarcinoma has been linked to infectious origin (parasitic), cholelithiasis, and liver tissue damage. 5,7,9 A potential predisposition for neoplastic transformation in the liver and bile duct is iron storage disease, which causes toxic hepatocellular changes, 11 although hepatic hemosiderosis was not present in our case. Cholangiocarcinoma in the Egyptian fruit bat (Rousettus aegyptiacus) is prevalent and has been associated with liver damage secondary to dietary excess of iron.…”

mentioning

confidence: 58%

Cholangiocarcinoma with carcinomatosis in a sugar glider

Williams,

Brum Rosa

2024

J VET Diagn Invest

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A 7-y-old, castrated male, leucistic sugar glider ( Petaurus breviceps) was presented because of a progressive history of lethargy, ataxia, diarrhea, and anorexia. Abdominal ultrasound revealed fluid in the abdomen and an infiltrative mass in the liver. Due to a poor prognosis, euthanasia was performed. Postmortem examination revealed a focally extensive, infiltrative, off-white, firm mass in the liver with adhesion to the omentum, mesentery, gastric serosa, and diaphragm. The remaining hepatic parenchyma was diffusely yellow. Histologically, the hepatic mass was consistent with metastatic cholangiocarcinoma (cholangiocellular carcinoma) with proliferation of neoplastic epithelial cells surrounded by marked desmoplasia. Neoplastic cells expanded and infiltrated the adjacent omentum, mesentery, and the serosal surfaces of the stomach, kidney, and small and large intestines. To our knowledge, cholangiocarcinoma has not been reported previously in a sugar glider.

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“…Other reported liver conditions in sugar gliders include hepatic lipidosis, 10,20 hepatocellular adenoma, 23 hepatocellular carcinoma, 3,4,23 haemosiderosis, 3,4,10,23 haemochromatosis, 10 listeriosis, 24,25 toxicity 20 and hepatic copper accumulation. 23 Hepatocellular tumours may be overrepresented in sugar gliders.…”

Section: Discussionmentioning

confidence: 99%

“…Reported neoplasms in sugar gliders ( Petaurus breviceps ) include mammary tumours, 1–3 adrenocortical carcinoma, 4 hepatocellular carcinoma, 3,4 dermal hemangiosarcoma, 5 paracloacal gland carcinoma, 6 pericloacal transitional cell carcinoma 7 and lymphoma 8,9 . Although neoplasia is relatively common in sugar gliders, 9,10 there are limited reports of clinical pathology and imaging findings for specific neoplasms.…”

Section: Introductionmentioning

confidence: 99%

Clinical, imaging and pathological features of hepatic carcinosarcoma in a sugar glider (Petaurus breviceps)

McCready,

Fisher,

McCleery

2023

Vet Record Case Reports

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A 5‐year 6‐month‐old, neutered, male sugar glider (Petaurus breviceps) presented for lethargy. Plasma biochemistry revealed severely elevated alkaline phosphatase and moderate hypercholesterolemia. A heterogenous liver and a right abdominal mass were noted on abdominal ultrasonography. Computed tomography revealed an enlarged liver with ill‐defined hypoattenuating regions and a heterogenous mass arising from the caudate lobe. Cytology of the liver was consistent with low‐grade mixed lipid and hydropic vacuolar change and mild to moderate mixed to mature lymphocytic infiltrate. Liver biopsies were declined, and the patient was managed with silymarin and prednisolone. Serial bloodwork and abdominal ultrasonography revealed persistently elevated alkaline phosphatase and progressive heterogenous hepatomegaly and hepatic nodules. The sugar glider died over 2 years after original presentation. On postmortem examination, there was a poorly differentiated hepatic neoplasm, with immunohistochemistry most consistent with a carcinosarcoma. In future cases, hepatic biopsies could be considered for sugar gliders presenting with hepatic masses when cytology is unrewarding.

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Concurrent Adrenocortical Carcinoma and Hepatocellular Carcinoma with Hemosiderosis in a Sugar Glider (Petaurus breviceps)

Cited by 13 publications

References 8 publications

From humans to hydra: patterns of cancer across the tree of life

From humans to hydra: patterns of cancer across the tree of life

Cholangiocarcinoma with carcinomatosis in a sugar glider

Clinical, imaging and pathological features of hepatic carcinosarcoma in a sugar glider (Petaurus breviceps)

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