Concurrent Medullary and Papillary Thyroid Carcinoma in the Same Thyroid Lobe and in Siblings

Lamberg, B.‐A.; Reissel, Pentti; Stenman, S; Koivuniemi, A; Ekblom, Marja; Mäkinen, Judit; Franssila, Kaarle

doi:10.1111/j.0954-6820.1981.tb11620.x

Cited by 46 publications

(14 citation statements)

References 11 publications

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“…The simultaneous occurrence of MTC and PTC in the same thyroid is a rare phenomenon that can be observed in two main settings: a mixed tumor showing dual differentiation [15] or a collision tumor (that is, a tumor with two separate and different components) [2-8]. Our case belongs to the latter category since lesions with features of MTC and PTC were detected in two different locations and separated by normal thyroid tissue.…”

Section: Discussionmentioning

confidence: 94%

Medullary and papillary carcinoma of the thyroid gland occurring as a collision tumor with lymph node metastasis: A case report

Alavi

Azarpira

2011

J Med Case Reports

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IntroductionPapillary thyroid carcinoma and medullary thyroid carcinoma are two different thyroid neoplasia. The simultaneous occurrence of medullary thyroid carcinoma and papillary thyroid carcinoma as a collison tumor with metastases from both lesions in the regional lymph nodes is a rare phenomenon.Case presentationA 32-year-old Iranian man presented with a fixed anterior neck mass. Ultrasonography revealed two separate thyroid nodules as well as a suspicious neck mass that appeared to be a metastatic lesion. The results of thyroid function tests were normal, but the preoperative calcitonin serum value was elevated. Our patient underwent a total thyroidectomy with neck exploration. Two separate and ill-defined solid lesions grossly in the right lobe were noticed. Histological and immunohistochemical studies of these lesions suggested the presence of medullary thyroid carcinoma and papillary thyroid carcinoma. The lymph nodes isolated from a neck dissection specimen showed metastases from both lesions.ConclusionsThe concomitant occurrence of papillary thyroid carcinoma and medullary thyroid carcinoma and the exact diagnosis of this uncommon event are important. The treatment strategy should be reconsidered in such cases, and genetic screening to exclude multiple endocrine neoplasia 2 syndromes should be performed. For papillary thyroid carcinoma, radioiodine therapy and thyroid-stimulating hormone suppressive therapy are performed. However, the treatment of medullary thyroid carcinoma is mostly radical surgery with no effective adjuvant therapy.

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Section: Discussionmentioning

confidence: 94%

Medullary and papillary carcinoma of the thyroid gland occurring as a collision tumor with lymph node metastasis: A case report

Alavi

Azarpira

2011

J Med Case Reports

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“…MTC with concurrent PTC (MTC/PTC) was initially described by Lamberg et al. in 1981, 2 and 65 cases were recorded in the English literature as of 2007 2–36 …”

Section: Introductionmentioning

confidence: 99%

Concurrent occurrence of medullary thyroid carcinoma and papillary thyroid carcinoma in the same thyroid should be considered as coincidental

Kim¹,

Gong²,

Kim³

et al. 2010

Clinical Endocrinology

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“…[6] Since then many cases were reported and studied at molecular levels to identify the possible pathogenesis of these tumours.…”

Section: Discussionmentioning

confidence: 99%

Co-Existence of Medullary and Papillary Carcinomas of Thyroid - Case Report and Brief Review of Literature

Narayanankutty¹,

Devadas²

2016

jemds

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BACKGROUND Co-existence of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) in the same thyroid is an extremely rare phenomenon. A few cases of such co-existence have been repored in literature. We report a case of 44-year-old lady who was detected to have thyroid swelling by her clinician, which on ultrasound was suggestive of multinodular goitre. Her thyroid function tests were normal. Fine needle aspiration cytology was suggestive of medullary carcinoma of thyroid. She underwent total thyroidectomy. Microscopically there were MTC foci on the right lobe with an adjacent foci of papillary carcinoma, both of which are separated by normal thyroid parenchyma. Left lobe also showed foci of PTC. Calcitonin, synaptophysin and chromogranin were positive in the MTC foci and thyroglobulin was positive in the PTC foci, confirming the diagnosis of coexistent MTC and PTC. Coexistent MTC and PTC is a rare clinical entity and should be considered in the differential diagnosis of thyroid tumours.

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Concurrent Medullary and Papillary Thyroid Carcinoma in the Same Thyroid Lobe and in Siblings

Abstract: ABSTRACT. Simultaneous occurrence of medullary and papillary thyroid carcinoma in the same gland is obviously extremely rare. One such patient is reported here and two pairs of sibs are described, one with medullary and the other with papillary thyroid carcinoma.

Cited by 46 publications

References 11 publications

Medullary and papillary carcinoma of the thyroid gland occurring as a collision tumor with lymph node metastasis: A case report

Medullary and papillary carcinoma of the thyroid gland occurring as a collision tumor with lymph node metastasis: A case report

Concurrent occurrence of medullary thyroid carcinoma and papillary thyroid carcinoma in the same thyroid should be considered as coincidental

Co-Existence of Medullary and Papillary Carcinomas of Thyroid - Case Report and Brief Review of Literature

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