Concurrent metastases of papillary thyroid carcinoma to the scalp and Meckel’s cave

Phelan, Patrick S.; Mull, Jamie L.; Rajput, Mohamed Z.; Musiek, Amy

doi:10.1136/bcr-2017-222552

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…The rarest secondary sites of thyroid cancer involvement that have been cited are at mammary level, renal area as well as pancreas, adrenals, cerebral, ovarian, parotids, and teguments (11,12,13). Cutaneous location varies from neck and head (majority) to exceptional sites as chest wall and of variable incidence for scalp (11,12,14,15). Underling neck muscle or Meckel's cave in association with local teguments has also been reported (15,16).…”

Section: Skin Metastasesmentioning

confidence: 99%

“…Cutaneous location varies from neck and head (majority) to exceptional sites as chest wall and of variable incidence for scalp (11,12,14,15). Underling neck muscle or Meckel's cave in association with local teguments has also been reported (15,16).…”

Section: Skin Metastasesmentioning

confidence: 99%

“…The presence of newly detected skin lump may be incidental and the connection with thyroid malignancy may not be evident at admission (14,15,16). Lately, incidental findings of solid, cystic or mix consistence, are not only clinically, but also radiological detected and their identification has an explosive incidence during last decades (22,23,24).…”

Section: Incidental Findingsmentioning

confidence: 99%

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Skin metastasis as incidental finding in follicular epithelium derived – thyroid cancer

Şandru¹,

Valea²,

Albu³

et al. 2020

Ro J Med Pract.

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Skin metastases are not typical. Malignancies like mammary cancer (most frequent in females) and pulmonary neoplasia (most frequent in males) represent the majority and exceptional findings are in those originating from thyroid, prostate, ovaries and oesophagus, usually in advanced, generally disseminated stages, with a poor prognosis. It may be found more often in elderly patients. We aim to present some practical aspects of skin metastases in thyroid cancer that originates from follicular thyroid epithelium. This is a brief literature review. The level of evidence is poor since most data is provided from cases reports. Cutaneous malignant lumps are rarely the first sign of disease, mostly associating a cancer relapse. The location varies from neck and head (majority) to exceptional sites as chest wall and of variable rate for scalp. Underling neck muscle or Meckel's cave metastasis may be associated. The lesion is usually a lump of medium to small size, sometimes of papular appearance, without local pain (but depends on the site); it may associate erythema. The diagnosis is difficult unless an index of suspicion is positive (in which case whole body radioiodine scintigram may be useful). Biopsy and histological report are essential for diagnosis especially in cases without an evident connection to a prior/synchronous thyroid malignancy. Knowing the exceptional prevalence, the need for awareness in this particular topic is connected with a multidisciplinary daily practice.

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Section: Skin Metastasesmentioning

confidence: 99%

Section: Skin Metastasesmentioning

confidence: 99%

Section: Incidental Findingsmentioning

confidence: 99%

See 1 more Smart Citation

Skin metastasis as incidental finding in follicular epithelium derived – thyroid cancer

Şandru¹,

Valea²,

Albu³

et al. 2020

Ro J Med Pract.

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Thyroid Cancer With Cutaneous Metastases

Sciscent,

Eberly,

Goyal

et al. 2024

Ear Nose Throat J

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Objectives: Thyroid carcinoma with cutaneous metastases is a rare clinical finding. Cutaneous metastases from thyroid carcinoma have been associated with a poor prognosis, but these data are limited to case reports. The exact mechanism of cutaneous metastases from thyroid carcinoma is not clear. Our study aims to report the demographic, clinical, and histologic findings of patients with cutaneous metastases from thyroid carcinoma. Methods: A review was conducted using the Medline/PubMed, Cochrane, and Scopus databases to review literature from inception to May 2023. Data extracted included patient age at diagnosis of cutaneous metastases, patient sex, thyroid carcinoma histotype, location of metastases, the time interval between diagnoses of thyroid carcinoma and cutaneous metastases, and overall survival (OS) from the time of cutaneous metastases. Results: One hundred thirty-six patients were identified and 75 were female. The most common types of thyroid carcinoma with cutaneous metastases were papillary (47.79%), followed by follicular (30.15%), and medullary (11.03%). In addition, 11 cases of anaplastic carcinoma, 2 cases of oncocytic carcinoma, and 2 cases of poorly differentiated thyroid carcinoma were reported. The average age at diagnosis of cutaneous metastases was 63.13 years, and the average time interval between the diagnoses of primary thyroid carcinoma and cutaneous metastases was 48.27 months. The most common location of metastases was the scalp (n = 48). Other common locations included the neck, chest, and face. The OS after diagnosis of metastases was only available in 34 patients with an average of 13.07 months. Of these 34 cases, 10 were medullary, 10 were papillary, 9 were anaplastic, and 5 had follicular carcinoma. Conclusions: This study represents an up-to-date review of the cases of thyroid carcinoma with cutaneous metastases. While cutaneous metastasis remains a rare finding, one needs a high index of suspicion, and their presence portends a poor prognosis.

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Efficacy of anlotinib combined with radioiodine to treat scalp metastasis of papillary thyroid cancer: A case report and review of literature

Zhang¹,

Cai²,

Liang³

et al. 2023

World J Clin Cases

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Concurrent metastases of papillary thyroid carcinoma to the scalp and Meckel’s cave

Cited by 3 publications

References 14 publications

Skin metastasis as incidental finding in follicular epithelium derived – thyroid cancer

Skin metastasis as incidental finding in follicular epithelium derived – thyroid cancer

Thyroid Cancer With Cutaneous Metastases

Efficacy of anlotinib combined with radioiodine to treat scalp metastasis of papillary thyroid cancer: A case report and review of literature

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