Concurrent PET/CT with an Integrated Imaging System: Intersociety Dialogue from the Joint Working Group of the American College of Radiology, the Society of Nuclear Medicine, and the Society of Computed Body Tomography and Magnetic Resonance

Coleman, R. Edward; Delbeke, Dominique; Guiberteau, Milton J.; Conti, Peter S.; Royal, Henry D.; Weinreb, Jeffrey C.; Siegel, Barry A.; Federle, Michael P.; Townsend, David W.; Berland, Lincoln L.

doi:10.1016/j.jacr.2005.03.014

Cited by 57 publications

(56 citation statements)

References 23 publications

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“…This lack of a histologic gold standard is a common problem in imaging studies and in clinical situations. Therefore, the status ''positive for malignancy'' was based on a clinically accepted concept (11,13,14). A falsely high sensitivity of both PET and PET/CT could be attributable to the fact that metastases that were not revealed by any imaging modality were not considered.…”

Section: Limitationsmentioning

confidence: 99%

“…Studies concerning the diagnosis of malignant tumors in adult patients have shown that integrated PET/CT scanners are superior in terms of overall sensitivity and specificity to PET or CT alone (11,13,14). In contrast, only a few studies have addressed integrated PET/CT for pediatric or adolescent malignancies (15)(16)(17), and further research is still needed (18)(19)(20)(21).…”

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confidence: 99%

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Significant Benefit of Multimodal Imaging: PET/CT Compared with PET Alone in Staging and Follow-up of Patients with Ewing Tumors

Gerth

Juergens²,

Dirksen³

et al. 2007

Journal of Nuclear Medicine

131

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Hybrid PET/CT was compared with PET alone in the staging and restaging of patients with Ewing tumor to assess the benefit of the combined imaging technique. Methods: A total of 163 18 F-FDG PET/CT studies performed in 53 patients (age: range, 4-38 y; median, 16.5 y) with histopathologically confirmed Ewing tumor were evaluated retrospectively. All PET/CT studies included low-dose CT for attenuation correction; in 91 examinations, additional diagnostic chest CT was performed. PET and CT data were assessed independently by 2 nuclear medicine physicians and 2 radiologists, respectively. Finally, both datasets were fused by use of software and analyzed by all 4 reviewers (consensus reading). Each lesion was scored with a 5-point scale. Biopsy, imaging, or clinical follow-up served as a standard of reference. Receiver operating characteristic (ROC) analyses were performed to evaluate PET and PET/CT performance characteristics. To measure the abilities to detect and correctly localize tumor foci, localization ROC (L-ROC) curves were generated for PET. Results: A total of 609 lesions were detected by PET alone. The hybrid PET/CT technique resulted in a change of score in 160 of these lesions (26%): higher scores in 23 lesions (4%) and lower scores in 137 lesions (23%). In 49 lesions detected by PET (8%), the localization had to be changed after image fusion. Additionally, 124 (21%) more lesions were found by PET/CT than by PET alone, resulting in a total of 733 lesions. As determined by lesion-based analysis, the sensitivity, specificity, and accuracy of PET were 71%, 95%, and 88%, respectively; the corresponding values for the hybrid PET/CT technique were 87%, 97%, and 94% (P , 0.0001). The areas under the curve in the ROC analysis were 0.82 for PET and 0.92 for PET/CT (P , 0.0001), and that in the L-ROC analysis was 0.66 for PET. Conclusion: PET/CT is significantly more accurate than PET alone for the detection and localization of lesions and improves staging for patients with Ewing tumor. The hybrid technique is superior to PET alone in terms of sensitivity, specificity, and accuracy, mainly because of the detection of new lesions.

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Section: Limitationsmentioning

confidence: 99%

mentioning

confidence: 99%

Significant Benefit of Multimodal Imaging: PET/CT Compared with PET Alone in Staging and Follow-up of Patients with Ewing Tumors

Gerth

Juergens²,

Dirksen³

et al. 2007

Journal of Nuclear Medicine

131

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“…• Adding significantly more experience in radiology to NM training programs: Beginning July 1, 2011, the training requirements in NM will mandate 4 to 6 months of training in CT, during which time it is possible to acquire experience in the interpretation of 500 CT cases (6). This amount of training is regarded as minimal and will not be sufficient if MRI becomes a necessary part of the training.…”

Section: Training Pathways For the Future: Recommendationsmentioning

confidence: 99%

ACR-SNM Task Force on Nuclear Medicine Training: Report of the Task Force: TABLE 1

Guiberteau¹,

Graham²

2011

J Nucl Med

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The expansion of knowledge and technological advances in nuclear medicine and radiology require physicians to have more expertise in functional and anatomic imaging. The convergence of these two specialties into the new discipline of molecular imaging has also begun to place demands on residency training programs for additional instruction in physiology and molecular biology. These changes have unmasked weaknesses in current nuclear medicine and radiology training programs. Adding to the impetus for change are the attendant realities of the job market and uncertain employment prospects for physicians trained in nuclear medicine but not also trained in diagnostic radiology. With this background, the ACR and the Society of Nuclear Medicine convened the Task Force on Nuclear Medicine Training to define the issues and develop recommendations for resident training.

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“…The early clinical applications of PET emerged in the field of neurology and cardiology (in the 1980s), and in oncology (in the 1990s) [1]. In the late 1990s 18 F-fluorodeoxyglucose (FDG) as the radiopharmaceutical began to be used widely in evaluation of oncology patients.…”

Section: Historical Perspectivementioning

confidence: 99%

“…In the late 1990s 18 F-fluorodeoxyglucose (FDG) as the radiopharmaceutical began to be used widely in evaluation of oncology patients. The clinical use of PET received a major boost in 1998, when reimbursement for PET scanning was approved by health care agencies in USA [1]. More recently, integration of Computed Tomography (CT) with PET into a composite inline PET/CT scanner has led to creation of a technological wonder that amalgamates functional information of PET with the anatomic information provided by the CT.…”

Section: Historical Perspectivementioning

confidence: 99%

Clinical Applications of PET and PET-CT

Anand¹,

Singh

Dash

2009

Medical Journal Armed Forces India

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Positron emission tomography (PET) and PET/ computed tomography (CT) are emerging as important imaging techniques and their popularity is growing within the medical fraternity. Though PET has been a useful research tool for many decades its real growth into clinical applications has occurred in the last one decade or so. Currently its major use is in oncologic imaging. However it has a multitude of clinical applications in cardiology, neurology and psychiatry as well. In oncologic imaging, a major a advantage of PET is that a single whole-body examination can provide accurate assessment of disease activity and spread. PET/CT amalgamates the functional information of PET with the structural details of the CT scan, thus greatly aiding in accurate staging, therapy response assessment and early detection of recurrent disease.

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Concurrent PET/CT with an Integrated Imaging System: Intersociety Dialogue from the Joint Working Group of the American College of Radiology, the Society of Nuclear Medicine, and the Society of Computed Body Tomography and Magnetic Resonance

Cited by 57 publications

References 23 publications

Significant Benefit of Multimodal Imaging: PET/CT Compared with PET Alone in Staging and Follow-up of Patients with Ewing Tumors

Significant Benefit of Multimodal Imaging: PET/CT Compared with PET Alone in Staging and Follow-up of Patients with Ewing Tumors

ACR-SNM Task Force on Nuclear Medicine Training: Report of the Task Force: TABLE 1

Clinical Applications of PET and PET-CT

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