Condensation nucleation light scattering detection with ion chromatography for direct determination of glyphosate and its metabolite in water

Analysis of glyphosate and aminomethylphosphonic acid in water, plant materials and soil

“…79 A limited number of methods have not used derivatization. The methods have used IC-CD, 18,26,34,35 IC-ICP-MS, 19,20,63,77 IC-CNLSD, 36,37 CE-C 4 D, 70 CE-FLD with fluorescein as a background fluorophore, 12 CE-ECL, 96 22 Of the analysis articles in the past 15 years, HPLC has been the most commonly used method of separation: ∼63% of the glyphosate/AMPA articles used HPLC, 16% used GC, 13% used CE/CZE and 8% used IC (Table 1). The remaining papers did not use separation methods prior to analysis by ELISA, direct infusion MS, ECD, flow injection and ECL.…”

Aerosol-based detectors for liquid chromatography

“…You and Koropchak [96] developed a cation exchange method for determination of the herbicide glyphosate and its major metabolite aminomethylphosaphonic acid (AMPA). The authors evaluated and compared two CNLSD detection systems: a laboratory made CNLSD system, and a prototype commercial CNLSD detector.…”

Simultaneous determination of polysorbate 20 and unbound polyethylene-glycol in protein solutions using new core–shell reversed phase column and condensation nucleation light scattering detection

“…The WCPC detector in the CNLSD will only condense vapor onto particles that are above a certain size, particles below this size are not counted. The increase in particle size tremendously increases the light-scattering signal and dramatically increases the sensitivity in comparison to ELSD [25]. Only particles above a critical size can act as condensation nucleation sites that increase the signal-noise ratio due to discrimination of small droplets from the mobile phase.…”