Condensation of Amines with S-Methyl Thiouronium Salts: Another Entry for the Synthesis of Amidines

Abstract

In this article, we have presented condensation of primary aryl and alkyl amines with S-methyl thiouronium salts to get N,N,N'-trisubstituted amidines. High yields, short reaction times and fair substrate scope are the noteworthy features of this protocol. Surprisingly, reaction of thiouronium salt with 4-aminopyridine yielded (4-methoxyphenyl)(piperidin-1-yl)methanone.