Conditional Recurrence-Free Survival after Oncologic Extended Resection for Gallbladder Cancer: An International Multicenter Analysis

Vega, Eduardo A.; Newhook, Timothy E.; Kawaguchi, Yoshikuni; Qiao, Wei; Bellis, Mario De; Okuno, Masayuki; Panettieri, Elena; Nishino, Hiroto; Duwe, Gregor; Piccino, Marco; Rose, Agostino Maria De; Ruzzenente, Andrea; Üemoto, Shinji; Vivanco, Marcelo; Chun, Yun Shin; Cao, Hop S. Tran; Tzeng, Ching Wei D.; Aretxabala, Xabier de; Seo, Satoru; Giuliante, Felice; Guglielmi, Alfredo; Viñuela, Eduardo; Vauthey, Jean Nicolas

doi:10.1245/s10434-021-09626-3

Cited by 16 publications

(13 citation statements)

References 31 publications

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“…These data are interesting in light of work previously published by our own group. Specifically, similar to Vega et al, 6 we had previously demonstrated that the odds of survival changed over time following resection of gallbladder cancer. For example, while actuarial survival decreased over time, conditional survival compared with 5-year actuarial survival increased after surgery.…”

supporting

confidence: 78%

“…1,4,5 In effect, the longer an individual has survived from treatment, the greater the chance of additional survival. In the current study, 6 Vega et al reported on the conditional recurrence-free survival (RFS) of patients following extended resection of gallbladder cancer.…”

mentioning

confidence: 84%

“…The study by Vega et al 6 has several limitations that should be noted. Data on CA19-9 levels were not complete and thus could not be included in the analyses.…”

mentioning

confidence: 92%

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Conditional Recurrence-Free Survival for Patients with Gallbladder Cancer: A Personalized Resource for Patients and Providers

Ejaz

Pawlik

2021

Ann Surg Oncol

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Gallbladder cancer is an aggressive biliary tract cancer in which surgical resection provides the only hope for longterm survival. However, even among eligible patients who undergo curative-intent surgical resection, 5-year overall survival (OS) is generally dismal, ranging from 5 to 26%.Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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confidence: 78%

mentioning

confidence: 84%

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Conditional Recurrence-Free Survival for Patients with Gallbladder Cancer: A Personalized Resource for Patients and Providers

Ejaz

Pawlik

2021

Ann Surg Oncol

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“…An international multicentre study in 2015 showed that patients with T2h had higher vascular invasion, neural invasion, and lymph node metastasis than patients with T2p, and T2h were often associated with worse prognosis [13]. The gallbladder adjacent to the hepatic side has no serosal layer, there are as many as 20 (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) gallbladder veins, and the tumour easily metastasises to the liver bed through the gallbladder veins [14]. RC was found in 31.4% of patients after index cholecystectomy, with the liver being the most common residual site.…”

Section: Discussionmentioning

confidence: 99%

Residual cancer is a strong predictor of survival in T3 incidental gallbladder cancer

You

Xie

Ling

et al. 2022

Preprint

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Background and PurposeIndex cholecystectomy is insufficient for curing T3 incidental gallbladder cancer (IGC), and once residual cancer (RC) is found, the prognosis is often poor. The purpose of this study was to investigate the effect of RC on the prognosis and the optimal choice of adjuvant therapy for R0 reresection patients with T3 IGC.MethodsWe retrospectively reviewed data from patients with T3 IGC who underwent radical reresection from January 2013 to December 2018. RC was defined as histologically proven cancer at reresection. Demographics and tumour treatment-related variables were analysed in correlation with RC and survival. Adjuvant (Adj) chemoradiotherapy (CRT) was correlated with overall survival (OS) and disease-free survival (DFS).ResultsOf the 167 patients with IGC who underwent surgery, 102 underwent radical extended resection. Thirty-two (31.4%) RCs were found. Hepatic side tumours (T3h) and both side tumours (T3h+T3p) were associated with the presence of RC. In multivariate analysis, RC and lymph node metastasis were independent prognostic factors for DFS and OS (P <0.05). RC was associated with a significantly shorter median OS (20 vs. 53 months; P<0.01) and DFS (11 vs. 40 months; P<0.001) despite R0 resection. For R0 reresection patients with RC and/or lymph node metastasis, Adj CRT significantly improved OS (P=0.024).ConclusionResidual cancer and lymphatic metastasis are important factors for the poor prognosis of T3 IGC despite R0 resection, and these patients should actively receive adjuvant therapy.

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“…In this study, 5 we reviewed patients who underwent curative-intent surgery for GBC at five centers in four countries. We found that the risk of recurrence peaked at 8 months, with 84% of recurrences seen within the first 18 months of follow-up.…”

Section: Presentmentioning

confidence: 99%

ASO Author Reflections: Gallbladder Cancer Research, “One for All and All for One” Strategy to Improve Research

2021

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Conditional Recurrence-Free Survival after Oncologic Extended Resection for Gallbladder Cancer: An International Multicenter Analysis

Cited by 16 publications

References 31 publications

Conditional Recurrence-Free Survival for Patients with Gallbladder Cancer: A Personalized Resource for Patients and Providers

Conditional Recurrence-Free Survival for Patients with Gallbladder Cancer: A Personalized Resource for Patients and Providers

Residual cancer is a strong predictor of survival in T3 incidental gallbladder cancer

ASO Author Reflections: Gallbladder Cancer Research, “One for All and All for One” Strategy to Improve Research

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