Conditioned fear to context is associated with increased Fos expression in the caudal ventrolateral region of the midbrain periaqueductal gray.

Carrive, Pascal; Leung, Preston; Harris, Justin A.; Paxinos, George

doi:10.1016/s0306-4522(97)83047-3

Cited by 153 publications

(84 citation statements)

References 72 publications

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“…Additional afferent projections were noted in regions, such as the prefrontal cortex, lateral septum, bed nuclei of the stria terminalis, other preoptic and hypothalamic nuclei, and the periaqueductal gray, which also expressed stress-induced Fos immunoreactivity. rPH projections to the periaqueductal gray (ter Horst and Luiten, 1986; Vertes and Crane, 1996) may be of importance due to their associations with defensive behavioral reactions that are frequently reported during stressor exposures (Liebman et al, 1970;LeDoux et al, 1988;Kim et al, 1993;Campeau and Watson, 1997;Carrive et al, 1997;Grissom et al, 2008). Together, these observations suggest that the rostral posterior hypothalamic nucleus is anatomically positioned to orchestrate multiple responses consistently evoked by diverse stress situations.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have provided anatomical and functional details of the neural circuits mediating specific stress-evoked responses, including neuroendocrine responses regulated by the hypothalamo-pituitary-adrenocortical (HPA) axis (Sawchenko, 1991;Sawchenko et al, 2000;Herman et al, 2003), various autonomic reactions controlled by brainstem and hypothalamic premotor regions (Cao and Morrison, 2003;Zaretsky et al, 2003a;Cerri and Morrison, 2006;Pham-Le et al, 2011), and behaviors organized through forebrain, hypothalamic, and brainstem circuits (Liebman et al, 1970;LeDoux et al, 1988;Kim et al, 1993;Campeau and Watson, 1997;Canteras et al, 1997;Carrive et al, 1997). All these responses display habituation upon repeated stress exposures (Armario et al, 1984;De Boer et al, 1988;van Raaij et al, 1997;Campeau et al, 2002), and decline at similar rates across different responses (Masini et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Evidence for the Integration of Stress-Related Signals by the Rostral Posterior Hypothalamic Nucleus in the Regulation of Acute and Repeated Stress-Evoked Hypothalamo-Pituitary-Adrenal Response in Rat

et al. 2016

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A likely adaptive process mitigating the effects of chronic stress is the phenomenon of stress habituation, which frequently reduces multiple stress-evoked responses to the same (homotypic) stressor experienced repeatedly. The current studies investigated putative brain circuits that may coordinate the reduction of stress-related responses associated with stress habituation, a process that is inadequately understood. Initially, two rat premotor regions that respectively regulate neuroendocrine (medial parvicellular region of the paraventricular hypothalamic nucleus [PaMP]) and autonomic (rostral medullary raphe pallidus [RPa]) responses were targeted with distinguishable retrograde tracers. Two to 3 weeks later, injected animals underwent loud noise stress, and their brains were processed for fluorescent immunohistochemical detection of the tracers and the immediate early gene Fos. A rostral region of the posterior hypothalamic nucleus (rPH), and to a lesser extent, the median preoptic nucleus, exhibited the highest numbers of retrogradely labeled cells from both the RPa and PaMP that were colocalized with loud noise-induced Fos expression. Injections of an anterograde tracer in the rPH confirmed these connections and suggested that this region may contribute to the coordination of multiple stress-related responses. This hypothesis was partially tested by posterior hypothalamic injections of small volumes of muscimol, which disrupts normal synaptic functions, before acute and repeated loud noise or restraint exposures. In addition to significantly reduced corticosterone release in response to these two distinct stressors, rPH muscimol disrupted habituation to each stressor modality, suggesting a novel and important contribution of the rostral posterior hypothalamic nucleus in this category of adaptive processes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evidence for the Integration of Stress-Related Signals by the Rostral Posterior Hypothalamic Nucleus in the Regulation of Acute and Repeated Stress-Evoked Hypothalamo-Pituitary-Adrenal Response in Rat

et al. 2016

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“…Summary of Axonal Inputs to Radial and Longitudinal Divisions of the Periaqueductal Gray (PAG) (Swanson, 2004) On the basis of functional and connectional data (Carrive et al, 1997;Comoli et al, 2003;Sukikara et al, 2006Sukikara et al, , 2010, we have subdivided the PAGvl into lateral (I) and ventral (v) subdivisions that are approximately equivalent to the dorsal and ventral halves of the PAGvl. The data were obtained from the current study and from the following pathway-tracing studies: LHAjp and LHAs (Hahn and Swanson, 2010); LHAsf (Goto et al, 2005); MPN (Simerly and Swanson, 1988); VMH ; PMd (Canteras and Swanson, 1992;Goto et al, 2005).…”

Section: Tablementioning

confidence: 99%

Connections of the lateral hypothalamic area juxtadorsomedial region in the male rat

Hahn

Swanson

2012

J of Comparative Neurology

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The connections of the lateral hypothalamic area juxtadorsomedial region (LHAjd) were investigated in a series of pathway-tracing experiments involving iontophoretic co-injection of the tracers Phaseolus vulgaris-leucoagglutinin (PHA-L; for outputs) and cholera toxin B subunit (CTB; for inputs). Results revealed that the LHAjd has connections with some 318 distinct gray matter regions encompassing all four subsystems-motor, sensory, cognitive, and behavioral state -included in a basic structure-function network model of the nervous system. Integration of these subsystems is necessary for the coordination and control of emotion and behavior, and in that regard the connections of the LHAjd indicate that it may have a prominent role. Furthermore, the LHAjd connections, together with the connections of other LHA differentiations studied similarly to date, indicate a distinct topographic organization that suggests each LHA differentiation has specifically differing degrees of involvement in the control of multiple behaviors. For the LHAjd, its involvement to a high degree in the control of defensive behavior, and to a lesser degree in the control of other behaviors, including ingestive and reproductive, is suggested. Moreover, the connections of the LHAjd suggest that its possible role in the control of these behaviors may be very broad in scope because they involve the somatic, neuroendocrine, and autonomic divisions of the nervous system. In addition, we suggest that connections between LHA differentiations may provide, at the level of the hypothalamus, a neuronal substrate for the coordinated control of multiple themes in the behavioral repertoire. INDEXING TERMShypothalamus; periaqueductal gray; hippocampal formation; behavior; motivation An emerging view of the lateral hypothalamic area (LHA) reveals a highly regionally differentiated neuronal architecture with correspondingly differentiated axonal connections characterized by an extensive divergent and convergent topographic organization (Swanson, 2004;Goto et al., 2005;Swanson et al., 2005;Hahn, 2010;Hahn and Swanson, 2010). Such an organization calls for an equivalently extensive comparative analysis of the underlying organization of the severally parceled LHA (16 provisional LHA regions within the hypothalamic lateral zone) (Swanson, 2004). In a previous article (Hahn and Swanson, 2010), we presented the results of a high-resolution analysis of the axonal inputs and outputs of the lateral hypothalamic area (LHA) juxtaparaventricular (LHAjp) and suprafornical (LHAs) regions-two differentiations of the hypothalamic lateral zone middle group within NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript respectively a medial (LHAjp) and perifornical (LHAs) tier of a recently revised parcellation for the LHA (Swanson, 2004;Swanson et al., 2005).The previous work showed that the LHAjp and LHAs have interregional connections with several hundred distinct gray matter regions encompassing all four subsystems (motor, sensory, cognitive, and...

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“…A porção ventral da PAG apresenta participação importante na organização das respostas de medo condicionado. Em particular, a resposta passiva de congelamento a estímulos condicionados contextuais de medo é também elaborada nesta região mesencefálica (Carrive et al, 1997;Walker et al, 2003).…”

Section: Substância Cinzenta Periaquedutalunclassified

Estudo da distribuição da proteína S100b em encéfalo de ratos.

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Conditioned fear to context is associated with increased Fos expression in the caudal ventrolateral region of the midbrain periaqueductal gray.

Cited by 153 publications

References 72 publications

Evidence for the Integration of Stress-Related Signals by the Rostral Posterior Hypothalamic Nucleus in the Regulation of Acute and Repeated Stress-Evoked Hypothalamo-Pituitary-Adrenal Response in Rat

Evidence for the Integration of Stress-Related Signals by the Rostral Posterior Hypothalamic Nucleus in the Regulation of Acute and Repeated Stress-Evoked Hypothalamo-Pituitary-Adrenal Response in Rat

Connections of the lateral hypothalamic area juxtadorsomedial region in the male rat

Estudo da distribuição da proteína S100b em encéfalo de ratos.

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