Conditioned place preference following concurrent treatment with 3, 4-methylenedioxypyrovalerone (MDPV) and methamphetamine in male and female Sprague-Dawley rats

Risca, Harmony I.; Zuarth-Gonzalez, Julio D.; Baker, Lisa E.

doi:10.1016/j.pbb.2020.173032

Cited by 18 publications

(13 citation statements)

References 30 publications

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“…Further, adolescents were more sensitive to the rewarding effects of nicotine (and less sensitive to its aversive effects) relative to adults (for comparison, see [ 168 ] who reported these same relative sensitivities of CPP and CTA when separately assessed). Other comparisons across studies have shown that place preference conditioning is comparable when assessed in a combined CTA/CPP design or as an independent CPP and that manipulations in either design impact place preference conditioning similarly (see [ 152 , 157 ] for assessments of the combined CTA/CPP assay with morphine compared to [ 169 , 170 ] for assessments of morphine using only CPP; for a similar comparison with MDPV, see [ 171 ] compared to [ 172 ]; for α -PVP, see [ 104 ] compared to [ 173 , 174 ]; and for caffeine, see [ 162 ] compared to [ 175 ]).…”

Section: Combined Taste Aversion/place Preference Proceduresmentioning

confidence: 99%

Impact of the Aversive Effects of Drugs on Their Use and Abuse

Riley

Manke

Huang

2022

Behavioural Neurology

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Drug use and abuse are complex issues in that the basis of each may involve different determinants and consequences, and the transition from one to the other may be equally multifaceted. A recent model of the addiction cycle (as proposed by Koob and his colleagues) illustrates how drug-taking patterns transition from impulsive (acute use) to compulsive (chronic use) as a function of various neuroadaptations leading to the downregulation of DA systems, upregulation of stress systems, and the dysregulation of the prefrontal/orbitofrontal cortex. Although the nature of reinforcement in the initiation and mediation of these effects may differ (positive vs. negative), the role of reinforcement in drug intake (acute and chronic) is well characterized. However, drugs of abuse have other stimulus properties that may be important in their use and abuse. One such property is their aversive effects that limit drug intake instead of initiating and maintaining it. Evidence of such effects comes from both clinical and preclinical populations. In support of this position, the present review describes the aversive effects of drugs (assessed primarily in conditioned taste aversion learning), the fact that they occur concurrently with reward as assessed in combined taste aversion/place preference designs, the role of aversive effects in drug-taking (in balance with their rewarding effects), the dissociation of these affective properties in that they can be affected in different ways by the same manipulations, and the impact of various parametric, experiential, and subject factors on the aversive effects of drugs and the consequent impact of these factors on their use and abuse potential.

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Section: Combined Taste Aversion/place Preference Proceduresmentioning

confidence: 99%

Impact of the Aversive Effects of Drugs on Their Use and Abuse

Riley

Manke

Huang

2022

Behavioural Neurology

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“…Consistent with this mechanism of action, some authors found that MDPV has powerful rewarding effects measured by ultrasonic vocalizations in rats in the self-administration paradigm (Simmons et al, 2018(Simmons et al, , 2017. In the same line, MDPV-induced rewarding effects in the conditioned place preference (CPP) in mice (Duart-Castells et al, 2020) and rats (Hicks et al, 2018;Risca et al, 2020).…”

Section: Highlightsmentioning

confidence: 71%

Cannabidiol Modulates the Motivational and Anxiety-Like Effects of 3,4-Methylenedioxypyrovalerone (MDPV) in Mice

Alegre-Zurano

López-Arnau

Luján

et al. 2021

Preprint

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3,4-methylenedioxypyrovalerone (MDPV) is a new psychoactive substance (NPS) and the most widespread and life-threatening synthetic cathinone of the “bath salts”. Preclinical research has proven the cocaine-like psychostimulant effects of MDPV and its potential for abuse. Cannabidiol (CBD) is a non-psychotropic phytocannabinoid that has emerged as a new potential treatment for drug addiction. Here, we tested the effects of CBD (20 mg/kg) on MDPV (2 mg/kg)-induced conditioned place preference and MDPV (0.05 and 0.075 mg/kg/infusion) self-administration paradigm. We also assessed the effects of the combination of CBD, and MDPV (3 and 4 mg/kg) on anxiety-like behaviour using the elevated plus maze (EPM). CBD mitigated the MDPV-induced conditioned place preference. On the contrary, CBD administration throughout the MDPV (0.075 mg/kg/infusion) self-administration increased drug-seeking and taking behaviours, but only in the high-responders group of mice. Additionally, CBD exerted anxiolytic-like effects, but only in MDPV-treated mice. Taken together, our results indicate that CBD modulation of MDPV-induced motivational responses in mice vary depending on the requirements of the learning task, resulting in a complex response. More research attempting to decipher the behavioural and molecular interactions between CBD and MDPV is needed.

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“…Compared with mild stimulants used for better concentration and performance during trading, farming, socialization, and leisure activities, heavy use and/or concomitant abuse of substances (poly-drug use behavior, such as Catha edulis and a designer drug) due to stronger psychostimulatory desire is rapidly growing ( Ali, 2018 ). Except for Catha edulis , the natural structural basis of emerging designer drugs, synthetic cathinones, as a preferred constitution and/or replacement, became increasingly abused ( Anderson and Carrier, 2009 ; Risca et al, 2020 ). In face of such overwhelming social problems induced by a complex combination of original plant and structure-modified analogs, the research frontiers would be transferred to pharmacological and toxicological effects and abuse risks of synthetic cathinones such as methcathinone (MC), mephedrone (MEPH), 4-methylmethcathinone (4-MMC), 3-fluoromethcathinone (3-FMC), and methylenedioxypyrovalerone (MDPV) ( Carlsson et al, 2018 ; Risca et al, 2020 ), or polydrug abuse.…”

Section: Discussionmentioning

confidence: 99%

“…Except for Catha edulis , the natural structural basis of emerging designer drugs, synthetic cathinones, as a preferred constitution and/or replacement, became increasingly abused ( Anderson and Carrier, 2009 ; Risca et al, 2020 ). In face of such overwhelming social problems induced by a complex combination of original plant and structure-modified analogs, the research frontiers would be transferred to pharmacological and toxicological effects and abuse risks of synthetic cathinones such as methcathinone (MC), mephedrone (MEPH), 4-methylmethcathinone (4-MMC), 3-fluoromethcathinone (3-FMC), and methylenedioxypyrovalerone (MDPV) ( Carlsson et al, 2018 ; Risca et al, 2020 ), or polydrug abuse.…”

Section: Discussionmentioning

confidence: 99%

Progress and Research Trends on Catha edulis (Vahl) Endl. (Catha edulis): A Review and Bibliometric Analysis

Liu

et al. 2021

Front. Pharmacol.

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Catha edulis (Vahl) Endl., known as Catha edulis or Khat is a traditional and regional plant for chewing, smoking and drinking, that has posed a worldwide public health problem due to its recent emerging abused consumption. In the face of the massive use of Catha edulis, we reviewed related publications to analyze the progress and research trends through bibliometric methods. After screening, a total of 514 scientific publications published from 1997 to 2020 were included by systematic retrieval from the Web of Science (WoS) database. According to further scientometric analysis, the annual number of publications output kept rising in most of the years. Ethiopia and the United States of America (USA) have been devoting significant contributions to the field. Though the research emphasis had been the chemical composition and pharmacological and toxicological effects for several years, the hot spots were transferred; the mechanism investigations of Catha edulis have been the focus in recent years, which might be continued in the future. Furthermore, co-operations of multi-disciplinary researchers are needed to minimize abuse harms and maximize the medicinal benefits of Catha edulis to human beings.

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Conditioned place preference following concurrent treatment with 3, 4-methylenedioxypyrovalerone (MDPV) and methamphetamine in male and female Sprague-Dawley rats

Cited by 18 publications

References 30 publications

Impact of the Aversive Effects of Drugs on Their Use and Abuse

Impact of the Aversive Effects of Drugs on Their Use and Abuse

Cannabidiol Modulates the Motivational and Anxiety-Like Effects of 3,4-Methylenedioxypyrovalerone (MDPV) in Mice

Progress and Research Trends on Catha edulis (Vahl) Endl. (Catha edulis): A Review and Bibliometric Analysis

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