Conditioning regimen with a 75% dose of standard busulfan/cyclophosphamide plus fludarabine before cord blood transplantation in older patients with AML and MDS

The major limitations of cord blood transplantation(CBT)for adults have been higher rates of engraftment failure and early mortality. The amelioration of conditioning regimens could contribute to the recent improvement of early mortality in CBT. Although total body irradiation(TBI) -based regimens have remained the preferred regimens for CBT in younger patients, engraftment and survival after myeloablative intravenous busulfan-based regimens have also been improved by the addition of low-dose TBI, and／or other chemotherapeutic drugs, particularly for elderly patients. Intensified conditioning regimen could also improve engraftment and survival after CBT. To clarify whether conditioning treatment based on granulocyte-colony stimulating factor (G-CSF) priming effect improves results of CBT, a multicenter randomized phase III study is under way in Japan.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Conditioning regimen with a 75% dose of standard busulfan/cyclophosphamide plus fludarabine before cord blood transplantation in older patients with AML and MDS

Cited by 3 publications

References 29 publications

Single cord blood transplantation for acute myeloid leukemia patients aged 60 years or older: a retrospective study in Japan

Single cord blood transplantation for acute myeloid leukemia patients aged 60 years or older: a retrospective study in Japan

Is outcome of older people with acute myeloid leukemia improving with new therapeutic approaches and stem cell transplantation?

Conditioning regimen of single-unit cord blood transplantation for hematological malignancy

Contact Info

Product

Resources

About