Conducting polymer nanoparticles for a voltage-controlled release of pharmacological chaperones

Enshaei, Hamidreza; Puiggalı́-Jou, Anna; Saperas, Núria; Alemán, Carlos

doi:10.1039/d1sm00036e

Cited by 8 publications

(4 citation statements)

References 43 publications

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“…Reproduced with permission. [81] Copyright 2019, John Wiley and Sons. respectively, were printed, where the authors proceeded with in vivo studies that revealed the successful transdural release of dexamethasone.…”

Section: Fabrication Of Cp-based Drug Delivery Systemsmentioning

confidence: 99%

“…Another study has explored developing PEDOT nanoparticles (PEDOT NPs) aiming to achieve higher sensitivity to the electrical stimulation for controlled and on‐demand release of the payload. [ 81 ] PEDOT NPs were loaded with pyrimethamine (PYR), a potent pharmacological chaperone used for the treatment of certain rare disorders. The particle size of loaded and unloaded PEDOT NPs were 215 ± 3 and 203 ± 1 nm, respectively; whereas the net surface charges were −26 ± 7 and −29 ± 6 mV for the loaded and unloaded, respectively.…”

Section: Cps In Drug Deliverymentioning

confidence: 99%

mentioning

confidence: 99%

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Electroactive Polymers for On‐Demand Drug Release

Alkahtani,

Elbadawi,

Chapman

et al. 2023

Adv Healthcare Materials

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Conductive materials have played a significant role in advancing society into the digital era. Such materials are able to harness the power of electricity and are used to control many aspects of our daily lives. Conductive polymers (CPs) are an emerging group of polymers that possess metal‐like conductivity yet retain desirable polymeric features, such as processability, mechanical properties and biodegradability. Upon receiving an electrical stimulus, CPs can be tailored to achieve a number of responses, such as harvesting energy, biosensing and stimulating tissue growth. The recent FDA approval of a CP‐based material for a medical device has invigorated their research in healthcare, including as biosensors, tissue engineering grafts and implants. In drug delivery, CPs can act as electrical switches, drug release is achieved at a flick of a switch, thereby providing unprecedented control over drug release. In this review, recent developments in CP as electro‐active polymers for voltage‐stimuli responsive drug delivery systems are evaluated. The review demonstrates the distinct drug release profiles achieved by electro‐active formulations, and both the precision and ease of stimuli response. This level of dynamism promises to yield “smart medicines” and warrants further research. The review concludes by providing an outlook to electro‐active formulations in drug delivery and highlighting their integral roles in healthcare IoT.This article is protected by copyright. All rights reserved

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Section: Fabrication Of Cp-based Drug Delivery Systemsmentioning

confidence: 99%

Section: Cps In Drug Deliverymentioning

confidence: 99%

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Electroactive Polymers for On‐Demand Drug Release

Alkahtani,

Elbadawi,

Chapman

et al. 2023

Adv Healthcare Materials

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“…In addition, polymeric nanoparticles can be used to deliver chaperones. For example, electro-responsive poly (3,4-ethylenedioxythiophene) nanoparticles were used to deliver small molecule compounds with chaperone-like activity [ 35 ]. This method also seems promising for the delivery of protein chaperones, at least small heat shock proteins.…”

Section: Effect Of Artificial Chaperones On the Pathological Transfor...mentioning

confidence: 99%

Regulation by Different Types of Chaperones of Amyloid Transformation of Proteins Involved in the Development of Neurodegenerative Diseases

Muronetz

Kudryavtseva

Leisi

et al. 2022

IJMS

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The review highlights various aspects of the influence of chaperones on amyloid proteins associated with the development of neurodegenerative diseases and includes studies conducted in our laboratory. Different sections of the article are devoted to the role of chaperones in the pathological transformation of alpha-synuclein and the prion protein. Information about the interaction of the chaperonins GroE and TRiC as well as polymer-based artificial chaperones with amyloidogenic proteins is summarized. Particular attention is paid to the effect of blocking chaperones by misfolded and amyloidogenic proteins. It was noted that the accumulation of functionally inactive chaperones blocked by misfolded proteins might cause the formation of amyloid aggregates and prevent the disassembly of fibrillar structures. Moreover, the blocking of chaperones by various forms of amyloid proteins might lead to pathological changes in the vital activity of cells due to the impaired folding of newly synthesized proteins and their subsequent processing. The final section of the article discusses both the little data on the role of gut microbiota in the propagation of synucleinopathies and prion diseases and the possible involvement of the bacterial chaperone GroE in these processes.

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Thermosensitive Hydrogel PNIPAAm‐Alg‐PEDOT for Sustainable and Efficient Water Purification Powered by Solar Energy

Naranjo,

Paulo‐Mirasol,

Lanzalaco

et al. 2024

Advanced Sustainable Systems

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Unrestricted access to clean drinking water is essential for the well‐being of the global population, yet this necessary resource is not universally guaranteed, particularly amidst the escalating climate crisis that accentuates disparities across regions. Harnessing solar energy in conjunction with advanced synthetic solar absorbent hydrogels (SAHs) is increasingly recognized as a promising solution and a significant challenge in addressing the purification of brackish water sustainably. This work outlines the development of a SAH using the thermosensitive polymer poly(N‐isopropylacrylamide) (PNIPAAm) in combination with alginate (Alg), enriched with poly(3,4‐ethylenedioxythiophene) (PEDOT) nanoparticles (NPs). Through solar evaporation tests using different conducting polymer (CP) concentrations, a discernible relationship between the ratio of free water to intermediate water (FW/IW) within the hydrogel structure and its performance is observed. The hydrogel's remarkable evaporation rate for synthetic seawater (2.82 kg m−2 h−1) aligns with the lowest FW/IW, which is directly related to a reduction in water vaporization enthalpy. Characterization of intermediate water enables easy adjustment of the optimal conductive polymer content within the hydrogel. This technology, based on thermosensitive materials, not only introduces innovative methodologies for designing and customizing functional composite materials but also aligns with global objectives by addressing challenges in sustainable drinking water supply without additional energy inputs.

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Conducting polymer nanoparticles for a voltage-controlled release of pharmacological chaperones

Abstract: Pharmacological chaperones (PCs) are low molecular weight chemical molecules used for patients for some rare diseases caused primarily by protein instability. Controlled and on-demand release of PCs through nanoparticles is...

Cited by 8 publications

References 43 publications

Electroactive Polymers for On‐Demand Drug Release

Electroactive Polymers for On‐Demand Drug Release

Regulation by Different Types of Chaperones of Amyloid Transformation of Proteins Involved in the Development of Neurodegenerative Diseases

Thermosensitive Hydrogel PNIPAAm‐Alg‐PEDOT for Sustainable and Efficient Water Purification Powered by Solar Energy

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