Conduction delay across the cavotricuspid isthmus block line caused by the gap near the inferior vena cava: the role of conduction block in the lower lateral right atrium

Sekihara, Takayuki; Miyazaki, Shinsuke; Hasegawa, Kanae; Aoyama, Daisetsu; Nodera, Minoru; Eguchi, Tomoya; Nagao, Moeko; Kakehashi, Shota; Mukai, Moe; Uzui, Hiroyasu; Tada, Hiroshi

doi:10.1007/s00380-021-02012-9

Cited by 2 publications

(2 citation statements)

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“…In fact, we observed this distribution of propagation velocity in the area surrounding the isthmus (Figure A.5). The existence of intrinsic functional block in this region of the RA and its relationship with the occurrence of persistent AFL have been reported previously 29,30 . The results of the present study warranted consideration of the anatomy of the reentry circuit as the underlying mechanism of aATP and demonstrated the importance of AFL simulation using a realistic 3D model.…”

Section: Discussionsupporting

confidence: 76%

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Transition mechanisms from atrial flutter to atrial fibrillation during anti‐tachycardia pacing therapy

Okada,

Washio,

Sugiura

et al. 2023

Pacing Clinical Electrophis

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BackgroundAtrial anti‐tachycardia pacing (aATP) has been shown to be effective for the termination of atrial tachyarrhythmias, but its success rate is still not high enough.ObjectiveThe main objective of this study was to investigate the mechanisms of atrial flutter (AFL) termination by aATP and the transition from AFL to atrial fibrillation (AF) during aATP.MethodsWe developed a multi‐scale model of the human atrium based on magnetic resonance images and examined the atrial electrophysiology of AFL during aATP with a ramp protocol.ResultsIn successful cases of aATP, paced excitation entered the excitable gap and collided with the leading edge of the reentrant wave front. Furthermore, the excitation propagating in the opposite direction collided with the trailing edge of the reentrant wave to terminate AFL. The second collision was made possible by the distribution of the wave propagation velocity in the atria. The detailed analysis revealed that the slowing of propagation velocity occurred at the exit of the sub‐Eustachian isthmus, probably due to source‐sink mismatch. During the transition from AFL to AF, the excitation collided with the refractory zone of the preceding wave and broke into multiple wave fronts to induce AF. A similar observation was made for the transition from AF to sinus rhythm. In both cases, the complex anatomy of the atria played an essential role.ConclusionThe complex anatomy of atria plays an essential role in the maintenance of stable AFL and its termination by aATP, which were revealed by the realistic three‐dimensional simulation model.

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Section: Discussionsupporting

confidence: 76%

“…previously. 29,30 The results of the present study warranted consideration of the anatomy of the reentry circuit as the underlying mechanism of aATP and demonstrated the importance of AFL simulation using a realistic 3D model.…”

Section: Mechanisms Of Atpmentioning

confidence: 61%