Conduction velocity through the somesthetic pathway in chronic renal failure

Obeso, J. A.; Martí-Massó, J F; Asín, J L; Remirez, M.V.; Irigoyen, V.; Iragui, M I; Carrera, Noa; Teijeira, J

doi:10.1016/0022-510x(79)90022-4

Cited by 6 publications

(4 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…16.17 The peripheral conduction abnormality seen in one of our patients (Patient 5) suggests that the neurophysiological disturbances precede the onset of clinical polyneuropathy. Our observations in this regard concur with those of Obeso et al 9 The reports of central conduction time abnormalities in chronic renal failure are limited. Obeso et a!.9 were not able to find significant changes in central conduction time in their 21 patients studied.…”

Section: Commentsupporting

confidence: 93%

“…[5][6][7] In addition, as has long been recognized, involvement of the peripheral nervous system mayor may not be clinically manifested. [8][9][10] Various investigative methods have been suggested in the objective evaluation of central and peripheral nervous system dysfunction in uremic, pre-dialytic conditions. 5 ,1cr- 13 Lewis et al.…”

mentioning

confidence: 99%

“…12 studied the effects of hemodialysis on longlatency somatosensory evoked potentials (LLSEP). The studies of Obeso et al 9 were restricted to pre-and postdialysis periods on chronic renal failure. These studies were not conclusive.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Changes in Short-Latency Somatosensory Evoked Potentials during Hemodialysis in Chronic Renal Failure

Ganji

Mahajan

1983

Clinical Electroencephalography

View full text Add to dashboard Cite

Section: Commentsupporting

confidence: 93%

mentioning

confidence: 99%

See 1 more Smart Citation

Changes in Short-Latency Somatosensory Evoked Potentials during Hemodialysis in Chronic Renal Failure

Ganji

Mahajan

1983

Clinical Electroencephalography

View full text Add to dashboard Cite

“…Studies of quantitative sensory testing in ESKD patients have demonstrated increased vibratory perception thresholds, most marked in the lower limbs,147 whereas somatosensory‐evoked potentials in ESKD patients demonstrate abnormalities of conduction along both the distal and proximal segments of peripheral somesthetic pathways, but less commonly along intracranial sensory pathways 25, 153, 166…”

Section: Clinical and Neurophysiological Findings In Generalized Uremmentioning

confidence: 99%

Uremic neuropathy: Clinical features and new pathophysiological insights

2006

View full text Add to dashboard Cite

Neuropathy is a common complication of end-stage kidney disease (ESKD), typically presenting as a distal symmetrical process with greater lower-limb than upper-limb involvement. The condition is of insidious onset, progressing over months. and has been estimated to be present in 60%-100% of patients on dialysis. Neuropathy generally only develops at glomerular filtration rates of less than 12 ml/min. The most frequent clinical features reflect large-fiber involvement, with paresthesias, reduction in deep tendon reflexes, impaired vibration sense, muscle wasting, and weakness. Nerve conduction studies demonstrate findings consistent with a generalized neuropathy of the axonal type. Patients may also develop autonomic features, with postural hypotension, impaired sweating, diarrhea, constipation, or impotence. The development of uremic neuropathy has been related previously to the retention of neurotoxic molecules in the middle molecular range, although this hypothesis lacked formal proof. Studies utilizing novel axonal excitability techniques have recently shed further light on the pathophysiology of this condition. Nerves of uremic patients have been shown to exist in a chronically depolarized state prior to dialysis, with subsequent improvement and normalization of resting membrane potential after dialysis. The degree of depolarization correlates with serum K(+), suggesting that chronic hyperkalemic depolarization plays an important role in the development of nerve dysfunction in ESKD. These recent findings suggest that maintenance of serum K(+) within normal limits between periods of dialysis, rather than simple avoidance of hyperkalemia, is likely to reduce the incidence and severity of uremic neuropathy.

show abstract

Proximal vs Distal Slowing of Nerve Conduction in Chronic Renal Failure Treated by Long-term Hemodialysis

Chokroverty¹

1982

Archives of Neurology

View full text Add to dashboard Cite

Conduction velocity through the somesthetic pathway in chronic renal failure

Cited by 6 publications

References 19 publications

Changes in Short-Latency Somatosensory Evoked Potentials during Hemodialysis in Chronic Renal Failure

Changes in Short-Latency Somatosensory Evoked Potentials during Hemodialysis in Chronic Renal Failure

Uremic neuropathy: Clinical features and new pathophysiological insights

Proximal vs Distal Slowing of Nerve Conduction in Chronic Renal Failure Treated by Long-term Hemodialysis

Contact Info

Product

Resources

About