Conductivity and fluorescence studies on the micellization properties of sodium cholate and sodium deoxycholate in aqueous medium at different temperatures: Effect of selected amino acids

Kinetics of formation of bile salt micelles from coarse-grained Langevin dynamics simulations

“…40 Our results thus do not support the mechanism initially proposed by Small and Ekwall, 17,43 that larger micelles form primarily by fusion of smaller ones. In apparent contradiction with our observations and the ultrasonic relaxation measurements 58 we mentioned above, recent conductivity measurements 34 have been interpreted to support the twostage mechanism proposed by Small and Ekwall. 17,43 It is our opinion, however, that such a conclusion may not be reached from those measurements.…”

“…21,22,[24][25][26][28][29][30][31][32] Molecular dynamics simulations using all-atom [28][29][30] and coarse-grained 31 models, indicate that both oligomers and micelles are primarily stabilized by hydrophobic interactions, in agreement with experimental data that indicates that micellization is entropy-driven because of the release of water molecules from the hydrophobic face of the bile salts. [32][33][34] While the static properties of pure bile micelles are reasonably well characterized as summarized above, considerably less is known about their mechanism of formation. Understanding this mechanism is important because the rate and extent to which lipophilic nutrients are solubilized in DMMs are directly related to the rate and extent of uptake by the body.…”

Effect of temperature and salts on the interaction of cetyltrimethylammonium bromide with ceftriaxone sodium trihydrate drug

“…It can also be used to treat gonorrhea. Although a number of studies on the interaction of surfactants with different solute molecules including drugs are reported in the literature [3][4][5][6][7][8][9], to the best of our knowledge very little is known about the interaction of CFT with CTAB. In our previous papers, interaction of cephalosporin and beta lactum antibiotic drugs with ionic surfactants such as hexadecyltrimethylammonium bromide (HDTAB), dodecyltrimethylammonium bromide (DTAB), cetyldimethylethylammonium bromide (CDMEAB) and sodium dodecyl sulfate (SDS) in water and in aqueous solution of different salts were reported [4][5][6][7].…”

Interaction between a hydrophobic rigid face and a flexible alkyl tail: Thermodynamics of self-assembling of sodium cholate and SDS

“…2. It is noted that the reported DH mic values are small so that they may be endothermic or exothermic at T = 298 K, (0.73 ± 0.04) kJÁmol À1 [43], (1.79 ± 0.03) kJÁmol À1 [44], (À1.89 ± 0.05) kJÁmol À1 [36], (À1.34 ± 0.08) kJÁmol À1 [43] and (À1.0 ± 0.1) kJÁmol À1 [40]. The enthalpy change lies in the range around (À2.0-2.0) kJÁmol À1 (Fig.…”

“…For T = 298 K, they obtained an interpolated value of the enthalpy of micellization of 1.59 kJÁmol À1 in water from polynomial fit to the experimental data at other temperatures, and around À1.7 kJÁmol À1 estimated from the curve of the temperature dependence of DG = ÀRTln cmc [38]. Furthermore the DH mic values at different temperatures, as obtained from various methods in literature [31,36,[38][39][40][41][42][43][44] are summarized in Table 2. For easier comparison, these reported DH mic values are also plotted as a function of temperature in Fig.…”