Condylar Resorption Following Compressive Mechanical Stress in Rabbit Model - Association of Matrix Metalloproteinases

Nogami, Shinnosuke; KATAOKA, YOSHIHIRO; Yamauchi, Kensuke; Yanagisawa, Yuta; Imoto, Kazuhiro; Kumasaka, Akira; Izumita, Kuniyuki; Kajita, Tomonari; Iikubo, Masahiro; Kumamoto, Hiroyuki; Takahashi, Tsuneo

doi:10.21873/invivo.12938

Cited by 4 publications

(4 citation statements)

References 26 publications

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“…Nogami et al 28 in an animal study demonstrated condylar resorption following compressive TMJ loading. Excessive loading may be related to parafunctional habits such as bruxism, clenching and gum chewing.…”

Section: Discussionmentioning

confidence: 97%

Idiopathic condylar resorption in adolescents: A scoping review

Nobrega,

Almeida,

Friesen

et al. 2024

J of Oral Rehabilitation

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ObjectiveIdiopathic condylar resorption (ICR), also known as progressive condylar resorption, is poorly understood, particularly in adolescent patients. Therefore, this scoping review aims to summarize the available literature on the prevalence, aetiology, pathogenesis, diagnostic process, treatment and/or any outcome regarding ICR in adolescent individuals.MethodsThis scoping review followed the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines and its extension for scoping reviews (PRISMA‐ScR), as well as Joanna Briggs Institute studies. The search strategy was defined adopting a core search structure for each source, and the search was performed on MEDLINE, EMBASE, Cochrane Library, Web of Science, Scopus and Google Scholar. After duplicate removal, two independent reviewers screened abstracts, followed by complete articles, to achieve the definition of included studies. Data collection was performed, and the extracted data were organized in tabular form, along with a narrative summary of main findings that aligns with the objective of this review.ResultsSix observational studies were included in this review. Three studies focused on signs and symptoms, one on prevalence and signs and symptoms, one on treatment and one on disease pathogenesis.ConclusionThis scoping review revealed inadequate published research regarding prevalence, aetiology, early diagnosis, pathogenesis and treatment of ICR in adolescents.

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Section: Discussionmentioning

confidence: 97%

Idiopathic condylar resorption in adolescents: A scoping review

Nobrega,

Almeida,

Friesen

et al. 2024

J of Oral Rehabilitation

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“…MMP-3 has also been shown to be mechanosensitive; either a single injurious compression or cyclic supra-physiologic compression results in upregulation of MMP-3 and subsequent proteoglycan loss and cartilage degradation. [25][26][27][28] Mechanical injury with forces similar to what would be borne by the cartilage at the time of articular fracture has been shown to upregulate MMP-3 between 10-fold and 250-fold. 29,30 As such, future work is needed to better understand the mechanobiologic response to injury and the role of mechanobiologic mechanisms on PTOA progression.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Intra-articular Fracture Energy and a Patient's Inflammatory Response

Haller,

Fink,

Smith

et al. 2024

Journal of Orthopaedic Trauma

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Objectives: Prior studies have demonstrated elevated inflammatory cytokine concentrations in the synovial fluid of articular fracture patients post-injury. Similarly, CT-based fracture energy measurements have been correlated to PTOA risk after pilon fracture. The purpose of this study was to determine the associations between synovial fluid cytokine levels, fracture energy, and overall trauma to the body in articular fracture patients. Methods: Acute tibial plateau, tibial plafond, and rotational ankle fracture patients were prospectively enrolled from December 2011 through January 1, 2019. Synovial fluid concentrations of IL-1β, IL-1RA, IL-6, IL-8, IL-10, MMP-1, MMP-3, and MMP-13 were quantified. Patient CT scans were used to calculate fracture energy. The Injury Severity Score (ISS) was used to relate cytokine levels to whole-body injury severity. Spearman’s rho correlation coefficients were calculated to assess the relationship between injury severity metrics and synovial fluid cytokine, chemokine, and MMP concentrations. Results: Eighty-seven patients were enrolled with 42 had a tibial plateau fractures (OTA/AO 41B1 – 2, 41B2-14, 41B3-3, 41C1-3, 41C2-4, 41C3-16), 24 patients had a tibial plafond fracture (OTA/AO 43B1 – 2, 43B2 – 4, 43B3 – 5, 43C1 – 2, 43C2-3, 43C3-8), and 21 had a rotational ankle fracture (OTA/AO 44B1-3, 44B2-3, 44B3-6, 44C1-4, 44C2-5). Fracture energy significantly differed between fracture patterns, with ankle fractures involving substantially less fracture energy (median = 2.92 J) than plafond (10.85 J, p<0.001) and plateau fractures (13.05 J, p<0.001). After adjustment for multiple comparisons, MMP-3 was significantly correlated with transformed fracture energy (r=0.41, 95% CI 0.22-0.58, p<0.001), while IL-1β was significantly correlated with ISS, (Spearman’s ρ=0.31, 95% CI 0.08 – 0.49, p=0.004). Conclusions: Synovial fluid MMP-3 concentration was significantly correlated with CT-quantified fracture energy in intra-articular fracture patients. Given that in clinical practice fracture energy tends to correlate with post-traumatic osteoarthritis (PTOA) risk, MMP-3 may warrant further investigation for its role in PTOA development after articular fracture.

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“…Although the role of the articular disc remains unclear, the mandibular head may resorb over time in non-retrograde articular disc dislocation [ 14 ]. A recent study demonstrated that loading on the anterior surface of the condylar induced MMP-13, which is involved in articular cartilage degradation in the condylar head [ 15 ]. One possible treatment for ICR is surgical therapy for the condylar, but we did not choose this option.…”

Section: Discussionmentioning

confidence: 99%

Two Cases of Idiopathic Condylar Resorption Due to Temporomandibular Joint (TMJ) Osteoarthritis Remodeled by Different Treatment Modalities

Nomoto,

Ota,

Sekine

2023

Cureus

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Condylar resorption is a condition of progressive and significant mandibular head resorption. We treated two patients with condylar resorption caused by temporomandibular joint (TMJ) osteoarthritis. The first patient was a 22-year-old female at the time of the initial examination. She had a history of orthodontic treatment and came to the clinic with a number of symptoms, including difficulty opening the mouth. Idiopathic condylar resorption was diagnosed, an occlusal splint was placed for approximately one year, and the patient was followed up for 12 years. The second patient was a 20-year-old female who had completed non-extraction orthodontic treatment by the age of 17 years. She came to the clinic with esthetic issues, such as an anterior open bite. Implant anchor screws were placed in the alveolar bone of the anterior teeth and intermaxillary fixation was performed. Case 1 had 12 years of follow-up, with CT scan results showing remodeling of the condylar. Case 2 is expected to shorten treatment time. However, the CT scan showed remodeling and improvement in the chief complaint.

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Condylar Resorption Following Compressive Mechanical Stress in Rabbit Model - Association of Matrix Metalloproteinases

Cited by 4 publications

References 26 publications

Idiopathic condylar resorption in adolescents: A scoping review

Idiopathic condylar resorption in adolescents: A scoping review

The Relationship Between Intra-articular Fracture Energy and a Patient's Inflammatory Response

Two Cases of Idiopathic Condylar Resorption Due to Temporomandibular Joint (TMJ) Osteoarthritis Remodeled by Different Treatment Modalities

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