Conectivopatías y psoriasis

Cuesta-Montero, L.; Belinchón, Isabel

doi:10.1016/j.ad.2011.03.002

Cited by 18 publications

(9 citation statements)

References 89 publications

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“…Most papers analyze individual cases or small groups of patients and cross-sectional studies are lacking. As one might expect, since SLE is more prevalent in women, the coexistence of Ps and SLE affects women more often as well [19,20].…”

Section: Discussionmentioning

confidence: 99%

“…Epigenetic mechanisms, DNA hypermethylation, histone H4 hypoacetylation and abnormal microRNA expression lead to T cell hyperactivation. Th1 and Th17 activation and the effects of IFN-γ, IL-2, IL-12, IL-17 and IL-23 produced by these cells play a crucial role in the pathogenesis of Ps [6,13,20,29,32]. The function of regulatory T cells (Tregs), which are responsible for destroying autoreactive lymphocytes, is also compromised [29].…”

Section: Discussionmentioning

confidence: 99%

“…In terms of the development of inflammation, B lymphocytes and Th2 lymphocytes play a major role in SLE, while in Ps these are predominantly Th1 lymphocytes. What is common for both disease entities is only the increased number of Th17 lymphocytes and increased serum IL-7 and IL-23 levels [20].…”

Section: Discussionmentioning

confidence: 99%

“…This is more common in patients with previously reported photosensitivity [21]. Tests that would be useful to determine patients at risk include ANA, anti-dsDNA, anti-Ro and skin biopsy for direct immunofluorescence [19,20].…”

Section: Discussionmentioning

confidence: 99%

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Psoriasis and systemic lupus erythematosus in children – literature review based on case report

et al. 2020

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Immune-mediated inflammatory diseases are a group of diseases characterized by generalized inflammation that results from immune dysregulation, especially involving the mechanisms of acquired immunity. These diseases may be familial, showing that genetic factors play an important role in their development. Additionally, the occurrence of one disease makes a patient prone to other diseases. However, the coexistence of systemic lupus erythematosus (SLE) and psoriasis (Ps) is very rare due to their distinct genetic determinants and mechanisms of pathogenesis. Treatment is also challenging, as medications used to treat one condition exacerbate or even trigger the symptoms of the other. This paper presents the case of a Ps patient with a family history of autoimmune diseases, who developed systemic lupus erythematosus during puberty, as well as a discussion on the coexistence of SLE and Ps in developmental age based on available literature searching for PubMed database and American College of Rheumatology and European League Against Rheumatism abstracts particularly in this subject.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Psoriasis and systemic lupus erythematosus in children – literature review based on case report

et al. 2020

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“…Este loci codifica parte do Antígeno Leucocitário Humano (HLA) do cromossoma 6p. 12,13 Alguns tipos de HLA (proteínas encarregadas de reconhecer e apresentar antígenos) parecem estar associados à psoríase: HLAB13, HLA-B17, HLA-B37, HLA-Bw16, HLA-Bw57 e HLA-DR7. O HLA-Cw6 está presente em mais de 80% dos casos de psoríase de início precoce e aumenta em 13 vezes o risco de se desenvolver psoríase.…”

Section: Discussão Discussão Discussão Discussão Discussãounclassified

Psoríase Eritrodérmica: relato de caso e revisão bibliográfica

Ferreira

Anjos

Yoshino

et al. 2014

Medicina (Ribeirão Preto)

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A eritrodermia é uma síndrome rara, responsável por eritema e descamação difusos, que acometem mais de 80 ou 90% da superfície corporal. É potencialmente grave, devido à associação com distúrbios hidroeletrolíticos e à colonização bacteriana. Entre as causas etiológicas estão presentes: doenças dermatológicas primárias, reação alérgica a certas drogas, doenças sistêmicas, além de neoplasias. No presente relato de caso, ilustramos um exemplo de eritrodermia de instalação grave e aguda, inicialmente tratado com corticoterapia sistêmica. O exame histopatológico da pele indicou o diagnóstico de psoríase eritrodérmica, que respondeu bem ao tratamento com ciclosporina, acitretina e etanercepte. Com base nesse relato, foi realizada uma revisão da literatura sobre as causas de dermatite esfoliativa e discutido o manejo de casos graves de psoríase.

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Not simply a matter of psoriatic arthritis: epidemiology of rheumatic diseases in psoriatic patients

et al. 2012

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This study investigated the occurrence of rheumatic conditions (RCs) in a psoriasis (PSO)-dedicated dermatological clinic. PSO subjects with musculo-skeletal discomfort, and/or carrying signs (articular/systemic, even asymptomatic) of RCs; and/or suffering flares of previously established psoriatic arthritis (PsA) were referred to rheumatologist for evaluation. Laboratory tests/imaging were performed as needed. Categorization adhered to RCs classification endorsed by the Italian Society of Rheumatology. Of the 1,200 psoriatic subjects, 277 (23.1 %) were enrolled (146 females). The mean age was 55.7 years (range 21-81), PSO duration was 13.5 years (range 0-62). Thirty-seven patients (13.4 %) were asymptomatic. On an average, 92 (7.6 %) patients/year were evaluated, of whom 79.4 % näive to rheumatological consultations (NRC). Osteoarthritis (OA) and PsA (isolated or combined) showed the highest prevalence, with 156 (56.3 %) and 110 cases (39.7 %), respectively. Among NRC subjects, the mean PsA annual incidence was 29.5 % (standard error of the mean ±5.4 %). Other RCs, isolated or associated with PsA/OA, were diagnosed in 31 cases (11.2 %). Thirty-two subjects (11.5 %) had arthralgias, 20 of whom due to congenital/mechanical disorders, the remaining were unclassifiable. In conclusion, the largest part (88.5 %) of PSO subjects referred to rheumatologist showed some RCs. On annual basis, 29.5 % of näive enrolled patients were diagnosed as PsA.

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Conectivopatías y psoriasis

Cited by 18 publications

References 89 publications

Psoriasis and systemic lupus erythematosus in children – literature review based on case report

Psoriasis and systemic lupus erythematosus in children – literature review based on case report

Psoríase Eritrodérmica: relato de caso e revisão bibliográfica

Not simply a matter of psoriatic arthritis: epidemiology of rheumatic diseases in psoriatic patients

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