Configurational and Conformational Studies in the Metallocene Field

SCHLÖGL, K.

doi:10.1016/b978-0-408-70121-1.50005-x

Cited by 1 publication

(3 citation statements)

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“…Later, the first chromatographic resolution of a ferrocene derivative was reported by Schlögl, who enantioseparated compound 47 on acetylated cellulose [15]. The partial enantioseparations of ferrocenes 48 [167] and 49 [168] (Figure 11) were also obtained by the Schlögl's group on partially acetylated cellulose, with benzene as mobile phase, and on microcrystalline triacetylcellulose with ethanol, respectively.…”

Section: Enantioseparation Of Planar Chiral Ferrocenesmentioning

confidence: 95%

“…The most prominent member of the metallocene family is ferrocene (M=Fe) (Fc) [9], the first sandwich complex discovered in early 1950s [10,11] and structurally F I G U R E 1 Planar chirality of metallocenes elucidated shortly after [12][13][14]. Due to its high stability and similar reactivity to benzene, the ferrocene chemistry developed rapidly and until the late 1960s, a large number of planar chiral ferrocenes were reported, in particular by the group of Schlögl [15,16].…”

Section: Introductionmentioning

confidence: 99%

“…elucidated shortly after [12–14]. Due to its high stability and similar reactivity to benzene, the ferrocene chemistry developed rapidly and until the late 1960s, a large number of planar chiral ferrocenes were reported, in particular by the group of Schlögl [15, 16].…”

Section: Introductionmentioning

confidence: 99%

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Ferrocene derivatives with planar chirality and their enantioseparation by liquid‐phase techniques

Peluso

Mamane

2022

Electrophoresis

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In the last decade, planar chiral ferrocenes have attracted a growing interest in several fields, particularly in asymmetric catalysis, medicinal chemistry, chiroptical spectroscopy and electrochemistry. In this frame, the access to pure or enriched enantiomers of planar chiral ferrocenes has become essential, relying on the availability of efficient asymmetric synthesis procedures and enantioseparation methods. Despite this, in enantioseparation science, these metallocenes were not comprehensively explored, and very few systematic analytical studies were reported in this field so far. On the other hand, enantioselective highperformance liquid chromatography has been frequently used by organic and organometallic chemists in order to measure the enantiomeric purity of planar chiral ferrocenes prepared by asymmetric synthesis. On these bases, this review aims to provide the reader with a comprehensive overview on the enantioseparation of planar chiral ferrocenes by discussing liquid-phase enantioseparation methods developed over time, integrating this main topic with the most relevant aspects of ferrocene chemistry. Thus, the main structural features of ferrocenes and the methods to model this class of metallocenes will be briefly summarized. In addition, planar chiral ferrocenes of applicative interest as well as the limits of asymmetric synthesis for the preparation of some classes of planar chiral ferrocenes will also be discussed with the aim to orient analytical scientists towards 'hot topics' and issues which are still open for accessing enantiomers of ferrocenes featured by planar chirality.

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Section: Enantioseparation Of Planar Chiral Ferrocenesmentioning

confidence: 95%