Confirmed Moisture Damage at Home, Respiratory Symptoms and Atopy in Early Life: A Birth-Cohort Study

Karvonen, Anne M.; Hyvärinen, Anne; Roponen, Marjut; Hoffmann, Matthias; Korppi, Matti; Remes, Sami; Mutius, Erika von; Nevalainen, Aino; Pekkanen, Juha

doi:10.1542/peds.2008-1590

Cited by 106 publications

(117 citation statements)

References 29 publications

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“…Mold and dampness in the children's homes were evaluated by parents in the questionnaire, and showed strong positive associations with most of the children's allergic symptoms in this study. This positive association agrees with reviews in the scientific literature [34,35], and with many cross-sectional [36] and birth-cohort studies [9,37] studies of dampness in home environments and children's asthmatic and allergic diseases in western countries. Studies from Taiwan, China, also support the positive association of indoor dampness with childhood asthma [38].…”

Section: Resultssupporting

confidence: 88%

Prenatal and early life home environment exposure in relation to preschool children’s asthma, allergic rhinitis and eczema in Taiyuan, China

et al. 2013

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Section: Resultssupporting

confidence: 88%

Prenatal and early life home environment exposure in relation to preschool children’s asthma, allergic rhinitis and eczema in Taiyuan, China

et al. 2013

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“…Visible mould exposure Wheeze Of the nine publications evaluating the longitudinal effect of early exposure to visible mould at home and wheezing in the first 3 yrs of life, seven studies observed a significant positive association [8,12,36,41,42,48,49]. In one US birth cohort study (the Cincinnati Childhood Allergy and Air Pollution Study) from IOSSIFOVA et al [8], the reported increase in risk was persistent from 1-3 yrs of age.…”

Section: Resultsmentioning

confidence: 99%

“…DIJKSTRA [29] DALES [16] DALES [32] PONSONBY [18] ZHENG [27] CHEN [25] FREEMAN [20] FREEMAN substudy [20] SPENGLER [19] PEKKANEN [33] DONG [17] DONG [22] ANTOVA [15] WARMAN [24] Summary (OR FAGBULE [34] VERHOEFF [31] LI [26] LI [35] MAIER [28] BRUNEKREEF [23] BRUNEKREEF [23] BRUNEKREEF [21] STRACHAN [37] STRACHAN [38] DIJKSTRA [29] DALES [16] SPENGLER [19] EMENIUS [36] ALPER [39] DONG [17] DONG [22] ANTOVA [15] ROSENBAUM [43] IOSSIFOVA [8] KARVONEN [42] Summary (OR LI [26] MAIER [28] BRUNEKREEF [23] BRUNEKREEF [23] CHEN [25] BIAGINI [45] IBARGOYEN-ROTETA [44] KOSKINEN substudy [47] KOSKINEN [47] LI [26] LI [35] BRUNEKREEF [21] DONG …”

Section: Discussionmentioning

confidence: 99%

Association between domestic mould and mould components, and asthma and allergy in children: a systematic review

Tischer¹,

Cm²,

Heinrich³

2011

Eur Respir J

146

108

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Critical reviews over the past 10 yrs have found increased respiratory and allergic health outcomes for children living in damp and mouldy environments. However, recent studies have suggested that early childhood exposure to specific mould components may actually protect children from developing allergy.We conducted a systematic review of observational studies published in English from January 1980 to July 2010. This review was conducted according to systematic guidelines for Metaanalyses of Observational Studies in Epidemiology (MOOSE). The literature was searched using a computerised bibliographic database, PubMed. In order to increase the quality of the reviewed studies, meta-analyses of the effects of visible mould exposure on allergic health outcomes were performed and we evaluated the findings according to the Bradford Hill criteria for evidence of causation.The literature search identified 1,398 peer-reviewed scientific publications, and 61 studies that fulfilled the inclusion criteria were included in this review. We observed increased risks of allergic respiratory health outcomes in children exposed to visible mould and mould spores. These findings were confirmed by the results of the meta-analysis and in line with the evaluation criteria according to Bradford Hill. Visible mould was positively associated with asthma (OR 1.49 (95% CI 1.28-1.72)), wheeze (OR 1.68 (95% CI 1.48-1.90)) and allergic rhinitis (OR 1.39 (95% CI 1.28-1.51)). However, there was a tendency of lower risk for allergic health outcomes in children exposed to mouldderived components such as (1,3)-b-D-glucan and extracellular polysaccharides.These findings suggest that home environments with visible mould and mould spore exposure increase the risk of allergic respiratory health outcomes in children. However, further investigations are needed to examine the effects of exposure to mould-derived components as the current literature is inconclusive. In order to disentangle the different effects of overall microbial exposure on children's health, research should focus on specific microbial markers in the home, in combination with new assessment techniques including molecular methods.

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“…The Lifeways study was one of the first to show that general practitioner-reported wheeze or asthma (52) Czech Republic 7577 1994 x Devereux et al (53) UK 1400 1997 x x Drouillet et al (54) France 1900 2003 x x x x Dubois et al (55) Canada 1450 1998 x x Eggesbo et al (56) Norway 2500 2003 x x x Emanuel et al (57) UK 3076 1958 x Gorden-Larsen et al (58) USA 14 706 1995 x Gracie et al (59) Canada 3388 2008 x x Grandjean et al (60) Faroe Islands 1022 1986 x x x x Guldner et al (61) France 4000 2002 x x Guxens et al (62) Spain 3768 1997 x x x x x Grazuleviciene et al (63) Lithuania 4405 2007 x Hawkes et al (64) Ireland 2185 2008 x Hawkins et al (65) UK 13 113 2000 x Hill et al (66) Wales 420 2009 x x Hryhorczuk et al (67) Ukraine 4510 1992 x x x Hui et al (68) Hong Kong 8327 1997 x x Hunt et al (69) Canada 521 1981 x x Inskip et al (70) UK 3159 1998 x x Jaddoe et al (71) Netherlands 10 000 2002 x Jedrychowski et al (72) Poland 432 2000 x x Kaplowitz et al (73) UK 224 1986 x x Karvonen et al (74) Finland 442 2002 x x x x Katier et al (75) Netherlands 2500 (95) Germany 2000 2011 x x x x Richiardi et al (96) Italy 7500 2005 x x x x Schaefer-Graf et al (97) Germany 324 1995 † x x Sekine et al (98) Japan 8941 1992 x x Skalkidou et al (99) Sweden 580 2009 x x Tsuchiya et al (100) Japan 1260 2007 x x van Eijsden et al (101) The Netherlands 6161 2003 x x x x Vandentorren et al (102) France 20 000 2011 x x x Vecchi Brumatti et al (103) Italy 900 when the child averaged 3 years was inversely associated with maternal fruit and vegetable and fish consumption during pregnancy (1...…”

Section: Dietary Patterns and Risk Of Childhood Wheezing Or Asthmamentioning

confidence: 99%

Longitudinal follow-up of the relationship between dietary intake and growth and development in the Lifeways cross-generation cohort study 2001–2013

et al. 2013

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In this paper we will review evidence on the early life and familial influences on childhood growth and development, with particular reference to the Lifeways cross-generation cohort study in the Republic of Ireland. The Lifeways cross-generation cohort study was established in 2001–2013 through two maternity hospitals in the Republic of Ireland and was one of many new cohort studies established worldwide in the millennium period. Mothers were recruited at first booking visit, completing a self-administered questionnaire, which included a 147 item semi-quantitative FFQ. Longitudinal follow-up is ongoing in 2013, with linkage data to hospital and general practice records and examination of children when aged 5 and 9 years. The study is one of very few containing data on grandparents of both lineages with at least one grandparent recruited at baseline. There have been consistent associations between parental and grandparental health status characteristics and children's outcomes, including infant birth-weight, BMI when child was aged 5 years and childhood wheeze or asthma when child was aged 3 and aged 5 years. In conclusion, empirical evidence to date shows consistent familial and cross-generational patterns, particularly in the maternal line.

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Confirmed Moisture Damage at Home, Respiratory Symptoms and Atopy in Early Life: A Birth-Cohort Study

Cited by 106 publications

References 29 publications

Prenatal and early life home environment exposure in relation to preschool children’s asthma, allergic rhinitis and eczema in Taiyuan, China

Prenatal and early life home environment exposure in relation to preschool children’s asthma, allergic rhinitis and eczema in Taiyuan, China

Association between domestic mould and mould components, and asthma and allergy in children: a systematic review

Longitudinal follow-up of the relationship between dietary intake and growth and development in the Lifeways cross-generation cohort study 2001–2013

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