Confocal laser endomicroscopy in the diagnosis of extrahepatic bile duct diseases

Abstract

Aim. To evaluate information content of confocal laser endomicroscopy with targeted biopsy in verifying etiology of extrahepatic bile duct strictures.Material and methods. There were 28 patients with extrahepatic bile duct strictures who underwent retrograde intervention with confocal laser endomicroscopy and targeted biopsy. Data of confocal laser endomicroscopy and biopsy were compared with final postoperative and histological diagnosis. Follow-up within 1–4 years after endoscopic treatment was also considered.Results. Diagnostic sensitivity, specificity and overall accuracy of the method in differential diagnosis of common bile duct strictures were 91.7%, 93.7% and 92.8%, respectively. Complication (acute edematous pancreatitis) occurred in 1 (3.6%) case.Conclusion. Confocal laser endomicroscopy is new effective method for in vivo microscopic assessment of mucous membrane. Despite technical complexity, the method is not associated with advanced morbidity and, accordingly, has no additional contraindications in comparison with ERCP.

Diagnostic accuracy of probe-based confocal laser endomicroscopy and tissue sampling by endoscopic retrograde cholangiopancreatography in indeterminate biliary strictures: a meta‑analysis

“…Three records were added after a manual review of the references of the 15 remaining articles retrieved. Eighteen studies published between 2008 and 2021 were finally included in the meta-analysis 13 – 30 . In total, there were 750 lesions reported by 18 studies, 12 prospective and 6 retrospectives in Table 1 .…”

“…The pCLE thus improves the accuracy of diagnosing indeterminate biliary strictures. With the development of pCLE technology and the improvement of the diagnostic classification of indeterminate biliary strictures, a series of studies have been published on the diagnosis of indeterminate biliary strictures in pCLE 13 – 30 . The present study will perform a meta-analysis to assess the accuracy of pCLE in diagnosing indeterminate biliary strictures and to compare the accuracy of pCLE and ERCP with brush cytology and intraductal biopsy in diagnosing indeterminate biliary strictures.…”

Diagnostic Accuracy of Probe-Based Confocal Laser Endomicroscopy and Tissue Sampling by Endoscopic Retrograde Cholangiopancreatography in Indeterminate Biliary Strictures: A Meta‑Analysis

“…The pCLE thus improves the accuracy of diagnosing indeterminate biliary strictures. With the development of pCLE technology and the improvement of the diagnostic classi cation of indeterminate biliary strictures, a series of studies have been published on the diagnosis of indeterminate biliary strictures in pCLE [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] . The present study will perform a meta-analysis to assess the accuracy of pCLE in diagnosing indeterminate biliary strictures and to compare the accuracy of pCLE and ERCP with brush cytology and intraductal biopsy in diagnosing indeterminate biliary strictures.…”